Results 131 to 140 of about 185,430 (311)

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Chemokine receptors in GtoPdb v.2025.1

Chemokine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Chemokine Receptors [459, 458, 32]) comprise a large subfamily of 7TM proteins that bind one or more chemokines, a large family of small cytokines typically possessing ...
Nomiyama, Hisayuki, Yoshie, Osamu, Luster, Andrew D., Power, Christine A., Proudfoot , Amanda E. I., Oppenheim, Joost J., Rot, Antal, Ben-Baruch, Adit, Locati, Massimo, Matsushima, Kouji, Murphy, Philip M., Graham, Gerard J., Burkhardt, Amanda M., Hills, Rebecca, Rosenkilde, Mette M., Sparre-Ulrich, Alexander H., Combadiere, Christophe, Bachelerie, Francoise, Nibbs, Robert J. B., Uddin, Mohib, Monaghan, Amy E., Farber, Joshua M., Sozzani, Silvano, Mantovani, Alberto, Förster, Reinhold, Moschovakis, Georgios L., Charo, Israel F., Zlotnik, Albert, Thelen, Marcus, Horuk, Richard   +29 more
core   +1 more source

Role of Chemokines and Chemokine Receptors in Rheumatoid Arthritis

ImmunoTargets and Therapy, 2020
Noha Mousaad Elemam,1 Suad Hannawi,2 Azzam A Maghazachi1 1College of Medicine and Sharjah Institute for Medical Research, University of Sharjah, Sharjah, United Arab Emirates; 2Ministry of Health and Prevention, Department of Rheumatology, Dubai, United ...
Elemam NM, Hannawi S, Maghazachi AA
doaj  

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Chapter 8. Activation mechanisms of chemokine receptors

, 2009
Udgivelsesdato: 2009-nullChemokine receptors belong to the large family of 7-transmembrane (7TM) G-protein-coupled receptors. These receptors are targeted and activated by a variety of different ligands, indicating that activation is a result of similar ...
Jensen, Pia C, Mette M. Rosenkilde, Rosenkilde, Mette M, Pia C. Jensen   +3 more
core   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Blockade of attachment and fusion receptors inhibits HIV-1 infection of human cervical tissue

, 2004
Identification of cellular factors involved in HIV-1 entry and transmission at mucosal surfaces is critical for understanding viral pathogenesis and development of effective prevention strategies. Here we describe the evaluation of HIV-1 entry inhibitors
Ines Frank, Griffin, GE, Griffin, George E., George E. Griffin, Santos, John J., John P. Moore, Robin J. Shattock, Shattock, Robin J., Watts, Patricia, John J. Santos, Patricia Watts, Santos, JJ, Shattock, RJ, Vennansha Williams, Williams, V, Moore, JP, Williams, Vennansha G., Robbiani, Melissa, Hu, Qinxue, Qinxue Hu, Pope, M, Melissa Pope, Moore, John P., Frank, Ines, Hu, Q, Frank, I, Watts, P   +26 more
core   +1 more source

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source