Results 11 to 20 of about 570,360 (347)
Nintedanib (BIBF 1120) for IPF: a tomorrow therapy? [PDF]
Multidisciplinary Respiratory Medicine, 2012 Idiopathic pulmonary fibrosis is a rare, life threatening disease characterized by an anarchic fibrogenesis, limited survival and few therapeutic options.
Antoniu Sabina A
doaj +4 more sources
Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis [PDF]
Cytokine & Growth Factor Reviews, 2005 Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert their pro-angiogenic activity by interacting with various endothelial cell surface receptors, including tyrosine kinase receptors, heparan-sulfate proteoglycans, and integrins.
PRESTA, Marco +5 more
openaire +3 more sources
The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration
Cells, 2021 Fibroblast growth factors (FGFs) are a large family of secretory molecules that act through tyrosine kinase receptors known as FGF receptors. They play crucial roles in a wide variety of cellular functions, including cell proliferation, survival ...
Mariya Farooq +3 more
semanticscholar +1 more source
VEGFR1-tyrosine kinase signaling in pulmonary fibrosis
Inflammation and Regeneration, 2021 Vascular endothelial growth factor (VEGF) is not only an important factor for angiogenesis but also lung development and homeostasis. VEGF-A binds three tyrosine kinase (TK) receptors VEGFR1–3.
Hideki Amano +4 more
doaj +1 more source
Fibroblast Growth Factor Signalling in the Diseased Nervous System
Molecular Neurobiology, 2021 Fibroblast growth factors (FGFs) act as key signalling molecules in brain development, maintenance, and repair. They influence the intricate relationship between myelinating cells and axons as well as the association of astrocytic and microglial ...
L. Klimaschewski, P. Claus
semanticscholar +1 more source
Mouse genetics identifies unique and overlapping functions of fibroblast growth factor receptors in keratinocytes [PDF]
, 2020 Fibroblast growth factors (FGFs) are key regulators of tissue development, homeostasis and repair, and abnormal FGF signalling is associated with various human diseases.
Ben-Yehuda Greenwald, Maya +9 more
core +2 more sources
British Journal of Cancer, 2020 Fibroblast growth factor receptors (FGFRs) are aberrantly activated through single-nucleotide variants, gene fusions and copy number amplifications in 5–10% of all human cancers, although this frequency increases to 10–30% in urothelial carcinoma and ...
M. Krook +7 more
semanticscholar +1 more source
Frontiers in Oncology, 2023 Nintedanib is a tyrosine kinase inhibitor of fibroblast growth factor-, vascular endothelial growth factor-, and platelet-derived growth factor receptors.
Shu Yan +6 more
doaj +1 more source
Oncogenic fusion protein BCR-FGFR1 requires the breakpoint cluster region-mediated oligomerization and chaperonin Hsp90 for activation. [PDF]
, 2020 Mutation and translocation of fibroblast growth factor receptors often lead to aberrant signaling and cancer. This work focuses on the t(8;22)(p11;q11) chromosomal translocation which creates the breakpoint cluster region (BCR) fibroblast growth factor ...
Bisom-Rapp, Ezra W +4 more
core +2 more sources
Journal of Pharmacy and Bioallied Sciences, 2021 Cellular signaling proteins maintain the basic activities of cell and communication, between the cells for normal growth and development and pathological situation as well.
Gururaj Narayana Rao +5 more
doaj +1 more source