Results 21 to 30 of about 142,564 (264)

Fibroblast growth factor receptors as novel therapeutic targets in SNF5-deleted malignant rhabdoid tumors. [PDF]

PLoS ONE, 2013
Malignant rhabdoid tumors (MRTs) are aggressive pediatric cancers arising in brain, kidney and soft tissues, which are characterized by loss of the tumor suppressor SNF5/SMARCB1.
Simon Wöhrle, Andreas Weiss, Moriko Ito, Audrey Kauffmann, Masato Murakami, Zainab Jagani, Anne Thuery, Beatrice Bauer-Probst, Flavia Reimann, Christelle Stamm, Astrid Pornon, Vincent Romanet, Vito Guagnano, Thomas Brümmendorf, William R Sellers, Francesco Hofmann, Charles W M Roberts, Diana Graus Porta   +17 more
doaj   +1 more source

Fibroblast growth factor receptors as targets for anticancer therapy in cholangiocarcinomas and urothelial carcinomas

Heliyon, 2023
Cholangiocarcinomas and urothelial carcinomas are lethal tumors worldwide and only a minority of patients are eligible for surgery at diagnosis.
Demi Wekking, Andrea Pretta, Serafina Martella, Alessandra Pia D'Agata, Joanna Joeun Choe, Nerina Denaro, Cinzia Solinas, Mario Scartozzi   +7 more
doaj   +1 more source

Therapeutic Targeting of Fibroblast Growth Factor Receptors in Gastric Cancer

Gastroenterology Research and Practice, 2015
Chemotherapy has become the global standard treatment for patients with metastatic or unresectable gastric cancer (GC), although outcomes remain unfavorable.
Mikito Inokuchi, Yoshitaka Fujimori, Sho Otsuki, Yuya Sato, Masatoshi Nakagawa, Kazuyuki Kojima   +5 more
doaj   +1 more source

Developmental process and expression patterns of fibroblast growth factor receptors in murine meniscus after birth

Di-san junyi daxue xuebao, 2019
Objective To observe the developmental process of murine meniscus after birth and investigate the expression patterns of 3 types of fibroblast growth factor receptors (FGFRs) during this process. Methods Mice at different ages (1 d old and 1, 2, 4, 6 and
LI Fangfang, XIE Yangl, HUANG Junlan, ZHANG Ruobin, JIANG Wanling   +4 more
doaj   +1 more source

Mesenchymal-Epithelial Interactome Analysis Reveals Essential Factors Required for Fibroblast-Free Alveolosphere Formation

iScience, 2019
Summary: Lung epithelial cells and fibroblasts are key cell populations in lung development. Fibroblasts support type 2 alveolar epithelial cells (AEC2) in the developing and mature lung.
Kazushige Shiraishi, Shigeyuki Shichino, Satoshi Ueha, Takuya Nakajima, Shinichi Hashimoto, Satoshi Yamazaki, Kouji Matsushima   +6 more
doaj   +1 more source

FGFR (fibroblast growth factor receptor) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2008
Review on FGFR3 (fibroblast growth factor receptor 3), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +3 more sources

Interleukin-17 receptor D (Sef) is a multi-functional regulator of cell signaling

Cell Communication and Signaling, 2021
Interleukin-17 receptor D (IL17RD or IL-17RD) also known as Sef (similar expression to fibroblast growth factor), is a single pass transmembrane protein that is reported to regulate several signaling pathways .
Shivangi Pande, Xuehui Yang, Robert Friesel   +2 more
doaj   +1 more source

Basic fibroblast growth factor and its receptors in human embryonic stem cells.

Folia Histochemica et Cytobiologica, 2005
Human embryonic stem cells (hESCs) are pluripotent stem cells with long-lasting capacity to self-renew and differentiate into various cell types of endodermal, ectodermal or mesodermal origin.
Ales Hampl, Petr Dvorak
doaj   +1 more source

Characterization of the cholangiocarcinoma drug pemigatinib against FGFR gatekeeper mutants

Communications Chemistry, 2022
Pemigatinib is an FDA-approved drug for the treatment of cholangiocarcinoma, but while it is known to target fibroblast growth factor receptors, its mechanism of action is still not fully understood.
Qianmeng Lin, Xiaojuan Chen, Lingzhi Qu, Ming Guo, Hudie Wei, Shuyan Dai, Longying Jiang, Yongheng Chen   +7 more
doaj   +1 more source

Signal transduction by fibroblast growth factor receptors [PDF]

Frontiers in Bioscience, 1999
The fibroblast growth factor family, with its prototype members acidic FGF (FGF-1) and basic FGF (FGF-2), binds to four related receptor tyrosine kinases, expressed on most types of cells in tissue culture. In many respects, the FGF receptors appear similar to other growth factor receptors. Thus, dimerization of receptor monomers upon ligand binding is
P, Klint, L, Claesson-Welsh
openaire   +2 more sources