Cancer Medicine, 2018 Unresectable hepatocellular carcinoma (uHCC) is one of the most lethal and prevalent cancers worldwide, and current systemic therapeutic options for uHCC are limited.
M. Matsuki +6 more
semanticscholar +1 more source
Characterization of the cholangiocarcinoma drug pemigatinib against FGFR gatekeeper mutants
Communications Chemistry, 2022 Pemigatinib is an FDA-approved drug for the treatment of cholangiocarcinoma, but while it is known to target fibroblast growth factor receptors, its mechanism of action is still not fully understood.
Qianmeng Lin +7 more
doaj +1 more source
Physiological Actions of Fibroblast Growth Factor-23
Frontiers in Endocrinology, 2018 Fibroblast growth factor-23 (FGF23) is a bone-derived hormone suppressing phosphate reabsorption and vitamin D hormone synthesis in the kidney. At physiological concentrations of the hormone, the endocrine actions of FGF23 in the kidney are αKlotho ...
R. Erben
semanticscholar +1 more source
Fibroblast growth factor receptor 4 single nucleotide polymorphism Gly388Arg in head and neck carcinomas [PDF]
, 2019 BACKGROUND Head and neck squamous cell carcinoma (HNSCC) is considered to be a progressive disease resulting from alterations in multiple genes regulating cell proliferation and differentiation like receptor tyrosine kinases (RTKs) and members of the ...
Bergmann, C. +5 more
core +2 more sources
Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers
Apoptosis, 2013 The fibroblast growth factor receptors (FGFRs) regulate important biological processes including cell proliferation and differentiation during development and tissue repair.
Kai Hung Tiong, L. Mah, C. Leong
semanticscholar +1 more source
Expression and localization of fibroblast growth factors and fibroblast growth factor receptors in the developing rat kidney [PDF]
Kidney International, 1999 Expression and localization of fibroblast growth factors and fibroblast growth factor receptors in the developing rat kidney.The permanent kidney, or metanephros, develops through a complex series of reciprocal inductive events and involves branching morphogenesis, tubulogenesis, angiogenesis, and tissue remodeling. Fibroblast growth factors (FGFs) are
John F. Bertram +5 more
openaire +3 more sources
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Distinct molecular interactions mediate neuronal process outgrowth on non-neuronal cell surfaces and extracellular matrices. [PDF]
, 1986 We have compared neurite outgrowth on extracellular matrix (ECM) constituents to outgrowth on glial and muscle cell surfaces. Embryonic chick ciliary ganglion (CG) neurons regenerate neurites rapidly on surfaces coated with laminin (LN), fibronectin (FN),
Bixby, JL, Reichardt, LF, Tomaselli, KJ
core +1 more source
Fibroblast growth factor receptors, developmental corruption and malignant disease.
Carcinogenesis, 2013 Fibroblast growth factors (FGF) are a family of ligands that bind to four different types of cell surface receptor entitled, FGFR1, FGFR2, FGFR3 and FGFR4. These receptors differ in their ligand binding affinity and tissue distribution.
F. Kelleher +4 more
semanticscholar +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source