Results 11 to 20 of about 793,543 (339)

Peptide ligand recognition by G protein-coupled receptors [PDF]

Frontiers in Pharmacology, 2015
The past few years have seen spectacular progress in the structure determination of G protein-coupled receptors (GPCRs). We now have structural representatives from classes A, B, C, and F.
Brian E Krumm, Reinhard eGrisshammer
doaj   +6 more sources

Acidic Tumor Microenvironment and pH-Sensing G protein-Coupled Receptors [PDF]

Frontiers in Physiology, 2013
The tumor microenvironment is acidic due to glycolytic cancer cell metabolism, hypoxia, and deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an important stress factor and selection force for cancer cell somatic ...
Calvin R. Justus, Lixue eDong, Li V. Yang   +2 more
doaj   +4 more sources

Designer lipid-like peptides [PDF]

, 2011
A crucial bottleneck in membrane protein studies, particularly G-protein coupled receptors, is the notorious difficulty of finding an optimal detergent that can solubilize them and maintain their stability and function. Here we report rapid production of
Baaske, Philipp, Braun, Dieter, Brown, Emily, Corin, Karolina, Duhr, Stefan, Jerabek-Willemsen, Moran, Luo, Yuan, Ravel, Deepali B., Song, Junyao, Wang, Xiaoqiang, Wienken, Christoph J., Zhang, Shuguang   +11 more
core   +7 more sources

G-protein-coupled receptors at a glance [PDF]

Journal of Cell Science, 2003
[No abstract available]
Wesley K, Kroeze, Douglas J, Sheffler, Bryan L, Roth   +2 more
openaire   +2 more sources

Atropine-functionalized gold nanoparticles binding to muscarinic receptors after passage across the intestinal epithelium

Royal Society Open Science, 2022
Gold nanoparticles have a high potential to be a treatment of diseases by their specific drug delivery properties and multivalent receptor stimulation.
Rebecca Claßen, Ervice Pouokam, Matthias Wickleder, Martin Diener, Annabelle Mattern   +4 more
doaj   +1 more source

Powdered G-Protein-Coupled Receptors [PDF]

The Journal of Physical Chemistry Letters, 2016
Preparation and storage of functional membrane proteins such as G-protein-coupled receptors (GPCRs) are crucial to the processes of drug delivery and discovery. Here, we describe a method of preparing powdered GPCRs using rhodopsin as the prototype. We purified rhodopsin in CHAPS detergent with low detergent to protein ratio so the bulk of the sample ...
Suchithranga M D C, Perera, Udeep, Chawla, Michael F, Brown   +2 more
openaire   +2 more sources

Constitutive Activity among Orphan Class-A G Protein Coupled Receptors. [PDF]

PLoS ONE, 2015
The purpose of this study was to evaluate the extent of constitutive activity among orphan class-A G protein coupled receptors within the cAMP signaling pathway.
Adam L Martin, Michael A Steurer, Robert S Aronstam   +2 more
doaj   +1 more source

Rules and mechanisms governing G protein coupling selectivity of GPCRs

Cell Reports, 2023
Summary: G protein-coupled receptors (GPCRs) convert extracellular stimuli into intracellular signaling by coupling to heterotrimeric G proteins of four classes: Gi/o, Gq, Gs, and G12/13.
Ikuo Masuho, Ryoji Kise, Pablo Gainza, Ee Von Moo, Xiaona Li, Ryosuke Tany, Hideko Wakasugi-Masuho, Bruno E. Correia, Kirill A. Martemyanov   +8 more
doaj   +1 more source

G-Protein-Coupled Receptors [PDF]

Journal of Biological Chemistry, 1998
G-protein-coupled receptors (GPCRs) constitute a huge family of membrane receptors to numerous hormones, neurotransmitters and diverse compounds. A large part of cardiovascular and neurological pharmacology is based upon the knowledge of these receptors and on the identification of molecules able to interfere with them, in an agonistic or antagonistic ...
openaire   +1 more source

Interaction of the Xanthine Nucleotide Binding Goα Mutant with G Protein-coupled Receptors [PDF]

, 1998
We constructed a double mutant version of the α subunit of Go that was regulated by xanthine nucleotides instead of guanine nucleotides (GoαX). We investigated the interaction between GoαX and G protein-coupled receptors in vitro.
Simon, Melvin I., Yu, Bo
core   +1 more source