B2 SINE RNA as a novel regulator of glucocorticoid receptor transcriptional activity
Neurobiology of Stress, 2023 Glucocorticoids are a key component to the cellular response to stress. Glucocorticoids act via glucocorticoid receptors found ubiquitously in the brain and body.
Andrew A. Bartlett +2 more
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Tissue-Specific Actions of Glucocorticoids on Apoptosis: A Double-Edged Sword
Cells, 2013 First described for their metabolic and immunosuppressive effects, glucocorticoids are widely prescribed in clinical settings of inflammation. However, glucocorticoids are also potent inducers of apoptosis in many cell types and tissues. This review will
Amanda L. Gruver-Yates +1 more
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The glucocorticoid hypothesis of depression: history and perspectives
Вавиловский журнал генетики и селекции, 2016 An abnormality in adaptation to negative life events is considered as one of the main causes of the development of depressive symptoms.
G. T. Shishkina, N. N. Dygalo
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Stability analysis of a hypothalamic-pituitary-adrenal axis model with inclusion of glucocorticoid receptor and memory [PDF]
AIP Conference Proceedings 1798, 020111, 2017, 2016 This paper analyzes a four-dimensional model of the hypothalamic-pituitary-adrenal (HPA) axis that includes the influence of the glucocorticoid receptor in the pituitary. Due to the spatial separation between the hypothalamus, pituitary and adrenal glands, distributed time delays are introduced in the mathematical model.
arxiv +1 more source
Glucocorticoid modulates angiotensin II receptor expression patterns and protects the heart from ischemia and reperfusion injury. [PDF]
PLoS ONE, 2014 Glucocorticoid regulates angiotensin II receptor (ATR) expression via activating glucocorticoid receptors and binding to glucocorticoid response elements.
Qin Xue +3 more
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Revising Berg-Purcell for finite receptor kinetics [PDF]
, 2021 From nutrient uptake, to chemoreception, to synaptic transmission, many systems in cell biology depend on molecules diffusing and binding to membrane receptors. Mathematical analysis of such systems often neglects the fact that receptors process molecules at finite kinetic rates.
arxiv +1 more source
Antidepressant-like mechanism of honokiol in a rodent model of corticosterone-induced depression [PDF]
Journal of Integrative Neuroscience, 2020 Depression is closely linked to hypothalamus-pituitary-adrenal axis hyperactivity. Honokiol, a biphenolic lignan compound obtained from the traditional Chinese medicine Magnolia officinalis, can reduce the activity of the hypothalamus-pituitary-adrenal ...
Bo Zhang, Yu Li, Miao Liu, Xiao-Hua Duan, Kai-Li Hu, Li-Na Li, Xue Yu, Hong-Sheng Chang
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Melanocortin Regulation of Inflammation
Frontiers in Endocrinology, 2019 Adrenocorticotropic hormone (ACTH), and α-, β-, and γ-melanocyte-stimulating hormones (α-, β-, γ-MSH), collectively known as melanocortins, together with their receptors (melanocortin receptors), are components of an ancient modulatory system.
Wei Wang +3 more
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Reduced steroid activation of elephant shark glucocorticoid and mineralocorticoid receptors after inserting four amino acids from the DNA-binding domain of lamprey corticoid receptor-1 [PDF]
arXiv, 2023 Atlantic sea lamprey contains two corticoid receptors (CRs), CR1 and CR2, that are identical except for a four amino acid insert (Thr-Arg-Gln-Gly) in the CR1 DNA-binding domain (DBD). Steroids are stronger transcriptional activators of CR2 than of CR1 suggesting that the insert reduces the transcriptional response of lamprey CR1 to steroids. The DBD in
arxiv
Steroids, Pregnancy and Fetal Development
Frontiers in Immunology, 2020 Maternal glucocorticoids critically rise during pregnancy reaching up to a 20-fold increase of mid-pregnancy concentrations. Concurrently, another steroid hormone, progesterone, increases.
Maria Emilia Solano, Petra Clara Arck
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