Results 211 to 220 of about 159,680 (288)

Pharmacological target sites for restoration of age-associated deficits in NMDA receptor-mediated norepinephrine release in brain. [PDF]

J Neurochem
Aljohani Y, Payne W, Yasuda RP, Olson T, Kellar KJ, Dezfuli G.   +5 more
europepmc   +1 more source

Translational Medicine in Alzheimer's Disease: The Journey of Donanemab From Discovery to Clinical Application

Chronic Diseases and Translational Medicine, EarlyView.
Donanemab, approved by the U.S. FDA in July 2024, targets amyloid plaques in the brain to treat Alzheimer's disease in patients with mild cognitive impairment or mild dementia. ABSTRACT Substantial research has been conducted to identify an efficient treatment for Alzheimer's disease (AD).
Nandhini Jayaprakash, Karthikeyan Elumalai   +1 more
wiley   +1 more source

Ca²⁺ waves in astrocytes: computational modeling and experimental data. [PDF]

Front Cell Neurosci
Musotto R, Wanderlingh U, Pioggia G.
europepmc   +1 more source

Contemporary Perspectives on Chronic Renal Disorders

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT The prevalence of renal diseases and its associated burden on healthcare have tremendously risen in the past few years. From simple markers assessing kidney function, current renal research delves into understanding the diseases at the cellular and molecular levels and not just at treating, but at improving quality of life, arresting ...
Deenadhayalan Ashok, Poornima Ajay Manjrekar, Bhushan C. Shetty, Sujina S. S, Rukmini Mysore Srikantiah, Sowndarya Kollampare   +5 more
wiley   +1 more source

Acute Alcohol-Induced Changes Measured With Metabotropic Glutamate Receptor 5 Positron Emission Tomography. [PDF]

Addict Biol
Raval NR, Smart K, Angarita GA, Miller R, Huang Y, Krystal JH, Carson RE, Cosgrove KP, O'Malley SS, Hillmer AT.   +9 more
europepmc   +1 more source

Acetylation‐Deacetylation‐Driven Natural Product Biosynthesis

ChemistryEurope, EarlyView.
This review summarizes the role of acetylation‐deacetylation in natural product biosynthesis, including acetylation followed by deacetylation after several biosynthetic steps, acetylation‐mediated rearrangement, acetylation‐triggered elimination, and the acetylation cycle as a regulatory mechanism. These processes are vital for the formation of complex
Huibin Wang, Ikuro Abe
wiley   +1 more source

A spatial model of autophosphorylation of CaMKII predicts that the lifetime of phospho-CaMKII after induction of synaptic plasticity is greatly prolonged by CaM-trapping. [PDF]

Front Synaptic Neurosci
Bartol TM, Ordyan M, Sejnowski TJ, Rangamani P, Kennedy MB.   +4 more
europepmc   +1 more source

Chirality in Transition Metal Dichalcogenide Nanostructures

Chemistry – A European Journal, Accepted Article.
The fascinating properties introduced by the breaking of the mirror symmetry have recently motivated a rising interest in chirality in nanomaterials. In particular, transition metal dichalcogenides are a wide group of technologically relevant two‐dimensional layered materials where recent efforts in the introduction of chirality have shown promising ...
Lorenzo Branzi, Joseph Martyn, Lucy Fitzsimmons, Yurii K. Gun'ko   +3 more
wiley   +1 more source

Diverse Physiological Roles of Kynurenine Pathway Metabolites: Updated Implications for Health and Disease. [PDF]

Metabolites
Wang Y, Zhang Y, Wang W, Zhang Y, Dong X, Liu Y.   +5 more
europepmc   +1 more source

Elevated pyramidal cell firing orchestrates arteriolar vasoconstriction through COX-2-derived prostaglandin E2 signaling. [PDF]

Elife
Le Gac B, Tournissac M, Belzic E, Picaud S, Dusart I, Soula H, Li D, Charpak S, Cauli B.   +8 more
europepmc   +1 more source