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Seminars in Cell & Developmental Biology, 2006
Pain is an important survival and protection mechanism for animals. However, chronic/persistent pain may be differentiated from normal physiological pain in that it confers no obvious advantage. An accumulating body of pharmacological, electrophysiological, and behavioral evidence is emerging in support of the notion that glutamate receptors play a ...
David, Bleakman +2 more
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Pain is an important survival and protection mechanism for animals. However, chronic/persistent pain may be differentiated from normal physiological pain in that it confers no obvious advantage. An accumulating body of pharmacological, electrophysiological, and behavioral evidence is emerging in support of the notion that glutamate receptors play a ...
David, Bleakman +2 more
openaire +2 more sources
Neurotransmitters: Elusive glutamate receptors
Current Biology, 1994Kainate-preferring glutamate receptors appear to be abundant in the central nervous system. We have recently begun to understand their properties, but their functions remain to be described.
D, Feldmeyer, S, Cull-Candy
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Glutamate receptor channel signatures
Trends in Pharmacological Sciences, 2001Genes encoding glutamate receptor channel subunits were identified in genomes from Drosophila melanogaster and Caenorhabditis elegans by homology search with amino acid sequences that participate in the conserved channel pore. The predicted sequences of the putative glutamate receptor subunits revealed a distinct channel pore signature for each ...
Sprengel, R. +5 more
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Inhibitory glutamate receptor channels
Molecular Neurobiology, 1996Inhibitory glutamate receptors (IGluRs) are a family of ion channel proteins closely related to ionotropic glycine and gamma-aminobutyric acid (GABA) receptors; They are gated directly by glutamate; the open channel is permeable to chloride and sometimes potassium. Physiologically and pharmacologically, IGluRs most closely resemble GABA receptors; they
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Pharmacology of the glutamate receptor
Progress in Neurobiology, 1988The history of pharmacological examinations of glutamate receptor agonists such as kainic acid, quisqualic acid, acromelic acid, L-CCG-I, DCG-IV and L-F2CCG-I was described. Kainic acid is one of the most potent excitants in the mammalian central neurons, and its powerful excitatory actions gave rise to the excitotoxic concept that glutamate destroys ...
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Metabotropic glutamate receptors
Pharmacology Biochemistry and Behavior, 2002openaire +2 more sources
Glutamate Receptors in Taste Receptor Cells
2007Glutamate plays a double role in the physiology of TRCs. As a free-occurring component of some foodstuff, glutamate is detected by TRCs and conveys information about the presence of protein-rich source. As a substance released by TRC and/or nerve endings, it is involved in cell-to-cell communication at chemical synapses in taste organs.
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