Results 1 to 10 of about 51,381 (211)

Granulocyte and granulocyte-macrophage colony-stimulating factors, their receptors and interleukin-3 levels in newborns

The Turkish Journal of Pediatrics, 1997
Serum levels of granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF) and interleukin-3 (IL-3) as well as neutrophil counts were studied on the first, second and fifth days after birth, in order ...
M Coşkun, F Kardelen, N Oygür, L Undar, A Savaş, O Yeğin   +5 more
doaj   +2 more sources

Granulocyte colony-stimulating factor and its receptor [PDF]

Blood, 1991
Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein of Mr of about 20,000, which stimulates proliferation and differentiation of progenitor cells of neutrophils. Recent clinical application of G-CSF has proven that this hormone is effective in treatment of patients suffering from neutropenia.
G D, Demetri, J D, Griffin
openaire   +5 more sources

Dissecting the role of CSF2RB expression in human regulatory T cells

Frontiers in Immunology, 2022
Colony stimulating factor 2 receptor subunit beta (CSF2RB; CD131) is the common subunit of the type I cytokine receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3 and IL-5. Interestingly, FOXP3+ regulatory T cells (
Beatriz F. Côrte-Real, Beatriz F. Côrte-Real, Rebeca Arroyo Hornero, Rebeca Arroyo Hornero, Aleksandra Dyczko, Aleksandra Dyczko, Ibrahim Hamad, Ibrahim Hamad, Markus Kleinewietfeld, Markus Kleinewietfeld, Markus Kleinewietfeld   +10 more
doaj   +1 more source

G-CSF as a suitable alternative to GM-CSF to boost dinutuximab-mediated neutrophil cytotoxicity in neuroblastoma treatment

Journal for ImmunoTherapy of Cancer, 2021
Background Current immunotherapy for patients with high-risk neuroblastoma involves the therapeutic antibody dinutuximab that targets GD2, a ganglioside expressed on the majority of neuroblastoma tumors.
Taco W Kuijpers, Timo K van den Berg, Paula Martinez Sanz, Dieke J van Rees, Lieke M J van Zogchel, Bart Klein, Panagiota Bouti, Hugo Olsman, Karin Schornagel, Ivana Kok, Ali Sunak, Kira Leeuwenburg, Ilse Timmerman, Miranda P Dierselhuis, Waleed M Kholosy, Jan J Molenaar, Robin van Bruggen, Hanke L Matlung, Godelieve A M Tytgat, Katka Franke   +19 more
doaj   +1 more source

Immunogenic fusion proteins induce neutralizing SARS-CoV-2 antibodies in the serum and milk of sheep

Biotechnology Reports, 2023
Antigen-specific polyclonal immunoglobulins derived from the serum, colostrum, or milk of immunized ruminant animals have potential as scalable therapeutics for the control of viral diseases including COVID-19. Here we show that the immunization of sheep
Gregory M. Jacobson, Kirsty Kraakman, Olivia Wallace, Jolyn Pan, Alex Hennebry, Grant Smolenski, Ray Cursons, Steve Hodgkinson, Adele Williamson, William Kelton   +9 more
doaj   +1 more source

Granulocyte Colony-Stimulating Factor Receptor Mutations in Myeloid Malignancy [PDF]

Frontiers in Oncology, 2014
Granulocyte colony-stimulating factor is a cytokine able to stimulate both myelopoiesis and hematopoietic stem cell mobilization, which has seen it used extensively in the clinic to aid hematopoietic recovery. It acts specifically via the homodimeric granulocyte colony-stimulating factor receptor (G-CSFR), which is principally expressed on the surface ...
Liongue, Clifford, Ward, Alister Curtis
openaire   +3 more sources

The Effects of Pro-Inflammatory Cytokines on Human Body and Their Relation with Diseases (Review Article)

Academic Science Journal, 2023
Cytokines are important mediators in inflammatory disorders that affect the entire body. Signaling molecules called pro-inflammatory cytokines, also known as inflammatory cytokines, are released by the immune system cells including macrophages and T ...
Khalid Shaalan Sahab , Mohammed Asaad Mahdi, Ammar M. K. AL-Azzawi   +2 more
doaj   +1 more source

Characterization of the receptor binding determinants of granulocyte colony stimulating factor [PDF]

Protein Science, 1997
AbstractWe performed a series of experiments using alanine‐scanning mutagenesis to locate side chains within human granulocyte colony‐stimulating factor (G‐CSF) that are involved in human G‐CSF receptor binding. We constructed a panel of 28 alanine mutants that examined all surface exposed residues on helices A and D, as well as all charged residues on
D C, Young, H, Zhan, Q L, Cheng, J, Hou, D J, Matthews   +4 more
openaire   +2 more sources

A fusion cytokine coupling GMCSF to IL9 induces heterologous receptor clustering and STAT1 hyperactivation through JAK2 promiscuity. [PDF]

PLoS ONE, 2013
Cytokine receptors are randomly distributed on the cell surface membrane and are activated upon binding of their extracellular ligands to mediate downstream cellular activities.
Pingxin Li, Shala Yuan, Jacques Galipeau
doaj   +1 more source

Swapping between Fas and Granulocyte Colony-stimulating Factor Receptor [PDF]

Journal of Biological Chemistry, 1996
Fas belongs to the tumor necrosis factor/nerve growth factor receptor family. The Fas ligand binds to its receptor, Fas, and induces apoptosis in Fas-bearing cells. The granulocyte colony-stimulating factor receptor (G-CSFR) is a member of the hemopoietic growth factor receptor family.
T, Takahashi, M, Tanaka, J, Ogasawara, T, Suda, H, Murakami, S, Nagata   +5 more
openaire   +2 more sources