Results 21 to 30 of about 51,381 (211)

Evidence for the Glycosylation of the Granulocyte Colony-Stimulating Factor Receptor

Biochemical and Biophysical Research Communications, 1994
The granulocyte colony-stimulating factor receptor (G-CSFR) was overexpressed in WEHI-3B D+ myelomonocytic leukemia cells by the transfection of an expression plasmid containing the murine G-CSFR cDNA. Two different forms of the G-CSFR were observed in these cells by western blotting.
J, Li, A C, Sartorelli
openaire   +2 more sources

Expression of Fc-Gamma Receptors of Neutrophils in Preterm Infants of Different Gestational Age

Вопросы современной педиатрии, 2016
Background: Premature infants have a high risk of bacterial infections facilitated by the immaturity of their immune system.Objective: Our aim was to study the expression of Fc-gamma receptors of neutrophils and the possibility of its modulation in ...
Vladimir E. Mukhin, Daria A. Praulova, Lyudmila L. Pankratyeva, Olga I. Mileva, Alexander G. Rumyantsev, Nikolay N. Volodin   +5 more
doaj   +1 more source

Sputum biomarkers and the prediction of clinical outcomes in patients with cystic fibrosis. [PDF]

, 2012
Lung function, acute pulmonary exacerbations (APE), and weight are the best clinical predictors of survival in cystic fibrosis (CF); however, underlying mechanisms are incompletely understood.
Rogers, S.L., Sturrock, A., Carveth, Holly, William Walsh, Christen Lane, Walsh, W., James Moore, Li, Yanping, Keogh, R.H., Cox, D.R., Jun Chen (4238), Li, Y., Holly Carveth (143299), Carveth Holly, Judy L. Jensen (143284), William Walsh (143288), Anne Sturrock (143317), Liou Theodore G., Robert Paine III (143322), Ruth H. Keogh (143278), Paine, Robert, Teresa Clark (143295), Hoidal, John R, Cox David R., Adler Frederick R., Moore James, Hoidal John R., Liou, T.G., Shaunessy L. Rogers (143305), Rogers Shaunessy L., David R. Cox (77429), John R. Hoidal (143328), Lane Christen, Lane, C., Ruth H Keogh, Chen, Jun, Packer Kristyn, Kristyn Packer (143291), Frederick R. Adler (143274), Packer, K., Paine Robert, Clark, Teresa, Keogh, Ruth H, Anne Sturrock, Paine, R., Theodore G Liou, David R Cox, Robert Paine, Walsh William, Packer, Kristyn, Hoidal, J.R., Jensen, Judy L, Sturrock, Anne, Yanping Li (90163), Moore, J., Sturrock Anne, Kristyn Packer, Shaunessy L Rogers, Frederick R Adler, Adler, F.R., Clark, T., Rogers, Shaunessy L, Jensen, J.L., Yanping Li, Keogh Ruth H., Chen Jun, Adler, Frederick R, Jun Chen, Liou, Theodore G, Clark Teresa, Theodore G. Liou (143270), Judy L Jensen, John R Hoidal, Li Yanping, Lane, Christen, Christen Lane (143311), Holly Carveth, Chen, J., James Moore (22922), Walsh, William, Teresa Clark, Carveth, H., Jensen Judy L., Cox, David R, Moore, James   +84 more
core   +1 more source

Functional domains of the granulocyte colony-stimulating factor receptor. [PDF]

The EMBO Journal, 1991
The granulocyte colony-stimulating factor (G-CSF) receptor has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region.
R, Fukunaga, E, Ishizaka-Ikeda, C X, Pan, Y, Seto, S, Nagata   +4 more
openaire   +2 more sources

Regulation of thrombopoietin receptor expression and function [PDF]

, 2004
Of the many cells in the body, the hematopoietic cells are among those with the highest rate of self-renewal and turnover. The production and destruction of these cells are tightly controlled by a number of hematopoietic growth factors, in particular by ...
Coers, Jörn
core   +1 more source

Innate Immune Response to House Dust Mite Allergens in Allergic Asthma

MCBS (Molecular and Cellular Biomedical Sciences), 2021
Asthma is a major health problem and one of the leading causes of death in the world. The prevalence of asthma in Indonesia is high, with a recurrence >50%.
Winna Soleha, Febriana Catur Iswanti
doaj   +1 more source

Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody

Cell Reports, 2014
Interleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Here, we report the crystal structure of the IL-3 receptor α chain (IL3Rα) in complex with the anti-leukemia ...
Sophie E. Broughton, Timothy R. Hercus, Matthew P. Hardy, Barbara J. McClure, Tracy L. Nero, Mara Dottore, Huy Huynh, Hal Braley, Emma F. Barry, Winnie L. Kan, Urmi Dhagat, Pierre Scotney, Dallas Hartman, Samantha J. Busfield, Catherine M. Owczarek, Andrew D. Nash, Nicholas J. Wilson, Michael W. Parker, Angel F. Lopez   +18 more
doaj   +1 more source

Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli? [PDF]

PLoS ONE, 2015
The ability of the Blood Brain Barrier (BBB) to maintain proper barrier functions, keeping an optimal environment for central nervous system (CNS) activity and regulating leukocytes' access, can be affected in CNS diseases.
Simona F Spampinato, Birgit Obermeier, Anne Cotleur, Anna Love, Yukio Takeshita, Yasuteru Sano, Takashi Kanda, Richard M Ransohoff   +7 more
doaj   +1 more source

Pancreatic ductal adenocarcinoma immune microenvironment and immunotherapy prospects

Chronic Diseases and Translational Medicine, 2020
The tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) is non-immunogenic, which consists of the stellate cells, fibroblasts, immune cells, extracellular matrix, and some other immune suppressive molecules.
Ke-Yu Li, Jia-Long Yuan, Diego Trafton, Jian-Xin Wang, Nan Niu, Chun-Hui Yuan, Xu-Bao Liu, Lei Zheng   +7 more
doaj   +1 more source

Gas6/TAM Signalling Negatively Regulates Inflammatory Induction of GM-CSF in Mouse Brain Microglia

Cells, 2021
Microglia and astrocytes are the main CNS glial cells responsible for the neuroinflammatory response, where they release a plethora of cytokines into the CNS inflammatory milieu.
Shannon E. Gilchrist, Grace M. Pennelli, Sassan Hafizi   +2 more
doaj   +1 more source