Results 31 to 40 of about 51,381 (211)
Hematopoietic stem cells (HSCs) are multipotent, self-renewing cells that can differentiate into myeloid or lymphoid cells. The mobilization and differentiation processes are affected by the external environment, such as extracellular matrix and soluble ...
Munther Alomari +5 more
doaj +1 more source
Blood eosinophils can be described as inflammatory-like (iEOS-like) and lung-resident-like (rEOS-like) eosinophils. This study is based on the hypothesis that eosinophilopoetins such as interleukin (IL)-3 and IL-5 and granulocyte-macrophage colony ...
Jolita Palacionyte +6 more
doaj +1 more source
Expression of granulocyte colony-stimulating factor receptor in rectal cancer
To evaluate whether granulocyte colony-stimulating factor receptor (G-CSFR) expression before preoperative irradiation can predict the radiosensitivity of rectal cancer.The expression of G-CSFR was examined, using immunohistochemistry, in biopsy specimens from 126 patients with locally advanced rectal adenocarcinoma before preoperative irradiation ...
Xiao-Dong, Yang +3 more
openaire +2 more sources
Characterization of granulocyte colony‐stimulating factor receptor expressed on human lymphocytes [PDF]
Summary. We have studied the characterization of granulocyte colony‐stimulating factor receptor (G‐CSFR) in human lymphocytes. About one‐third to one‐quarter of the B lymphocytes from peripheral B‐cell sources displayed G‐CSF binding on the two‐colour immunofluorescence study.
Keiko, Morikawa +3 more
openaire +2 more sources
Cloning and Expression of Bioactive Human Granulocyte Colony Stimulating Factor in Pichia pastoris
For over ten years, recombinant human Granulocyte Colony Stimulating Factor (hG-CSF) has been broadly used in clinical applications. Many sources of G-CSF have the disadvantage of being in intracellular or aggregated form.
簡素芳; Chien, Su-Fang +1 more
core +1 more source
Rhinoviruses cause the majority of common colds, which often provoke wheezing in patients with asthma. The precise mechanisms responsible for the rhinovirus infection-induced exacerbations of bronchial asthma remain uncertain.
Mutsuo Yamaya, Hidetada Sasaki
doaj +1 more source
Prognosis in pediatric patients with refractory/relapsed acute myeloid leukemia (AML) is grim, and there is no standard treatment for such patients. Combined treatment with intensive chemotherapy and gemtuzumab ozogamicin (GO), a monoclonal anti-CD33 ...
Daisuke Toyama +9 more
doaj +1 more source
Activation Mechanism of Granulocyte Colony-Stimulating Factor Receptor
The crystal structure of the signaling complex of human granulocyte colony-stimulating factor (GCSF) and ligand binding region of human GCSF receptor (GCSF-R) has been determined to 2.8 A resolution. The GCSF : GCSF-R complex formed a 2 : 2 stoichiometry via a crossover interaction between the Ig-like domains of GCSF-R and GCSF. The conformation of the
TAMADA, Taro +2 more
openaire +2 more sources
Granulocyte colony-stimulating factor and its receptor in acute promyelocytic leukemia [PDF]
Expression of granulocyte colony-stimulating factor (G-CSF) receptor (G-CSFR) and in vitro proliferative response to G-CSF were investigated by quantitative immunofluorescence and [3H] thymidine uptake, respectively, in a series of acute myeloid leukemias (AML).
N, Katayama +11 more
openaire +2 more sources
G protein coupled receptor transcripts in human immune cells and platelets
G-protein coupled receptors (GPCRs) are encoded by nonabundant mRNAs, and it is difficult to detect them reliably with the highly parallel methods that are in general use.
Arne Hansen +8 more
doaj +1 more source

