Results 51 to 60 of about 51,381 (211)

Expression of functional granulocyte colony-stimulating factor receptors on human B-lymphocytic leukemia cells.

, 2000
We analyzed the expression of cell surface antigens and granulocyte colony-stimulating factor (G-CSF) receptors using flow cytometry, the expression of G-CSF mRNA receptor, using reverse transcription (RT)-PCR, and tested the effect of G-CSF on leukemia ...
Hirashima, K, Kashimura, T, Yamamoto, A, Takeuchi, S, Murohashi, I, Bessho, M, Handa, A   +6 more
core   +1 more source

The effect of toll-like receptor ligands on energy metabolism and myokine expression and secretion in cultured human skeletal muscle cells

Scientific Reports, 2021
Skeletal muscle plays an important role in glycaemic control and metabolic homeostasis, making it a tissue of interest with respect to type 2 diabetes mellitus.
Ragna H. Tingstad, Frode Norheim, Fred Haugen, Yuan Z. Feng, Hege S. Tunsjø, G. Hege Thoresen, Arild C. Rustan, Colin Charnock, Vigdis Aas   +8 more
doaj   +1 more source

Origins and functions of phagocytes in the embryo

, 2000
Objective. To review the data on the origins, phenotype, and function of embryonic phagocytes that has accumulated over past decade. Data Sources. Most of the relevant articles were selected based on the PubMed database entries.
Lichanska, A M, Agnieszka M Lichanska, David A Hume, Lichanska, A. M., Hume, D. A., Hume, D A   +5 more
core   +1 more source

Effects of Stem Cell Factor on Hypoxia-Inducible Factor 1 Alpha Accumulation in Human Acute Myeloid Leukaemia and LAD2 Mast Cells [PDF]

, 2011
Stem cell factor (SCF) is a hematopoietic growth factor that exerts its activity by signalling through the tyrosine kinase receptor known as Kit or CD117.
Bernhard F. Gibbs, Sumbayev, Vadim V., Yasinska, Inna M., Gibbs, Bernhard F., Vadim V. Sumbayev, Inna M Yasinska, Abraham E. Oniku, Vadim V Sumbayev, Oniku, Abraham E., Bernhard F Gibbs, Abraham E Oniku, Inna M. Yasinska   +11 more
core   +1 more source

Differential Constitutive and Cytokine-Modulated Expression of Human Toll-like Receptors in Primary Neutrophils, Monocytes, and Macrophages

International Journal of Medical Sciences, 2008
Human Toll-like receptors (TLRs) comprise a family of proteins that recognizes pathogen-associated molecular patterns (PAMPs) and initiates host innate immune responses.
D. Shane O'Mahony, Uyenvy Pham, Ramesh Iyer, Thomas R. Hawn, W. Conrad Liles
doaj  

Role of the Neutrophil in the Pathogenesis of Advanced Cancer and Impaired Responsiveness to Therapy

Molecules, 2020
Notwithstanding the well-recognized involvement of chronic neutrophilic inflammation in the initiation phase of many types of epithelial cancers, a growing body of evidence has also implicated these cells in the pathogenesis of the later phases of cancer
Bernardo L. Rapoport, Helen C. Steel, Annette J. Theron, Teresa Smit, Ronald Anderson   +4 more
doaj   +1 more source

HDAC1 fine-tunes Th17 polarization in vivo to restrain tissue damage in fungal infections

Cell Reports
Summary: Histone deacetylases (HDACs) contribute to shaping many aspects of T cell lineage functions in anti-infective surveillance; however, their role in fungus-specific immune responses remains poorly understood.
Philipp Penninger, Helena Brezovec, Irina Tsymala, Magdalena Teufl, Trinh Phan-Canh, Tamires Bitencourt, Marie Brinkmann, Walter Glaser, Wilfried Ellmeier, Michael Bonelli, Karl Kuchler   +10 more
doaj   +1 more source

Identification of osteopontin-dependent signaling pathways in a mouse model of human breast cancer

BMC Research Notes, 2009
Background Osteopontin (OPN) is a secreted phosphoprotein which functions as a cell attachment protein and cytokine that signals through two cell adhesion molecules, αvβ3-integrin and CD44, to regulate cancer growth and metastasis. However, the signaling
Guo Hongtao, Mi Zhiyong, Kuo Paul C
doaj   +1 more source

Stanozolol and Danazol Have Different Effects on Hematopoiesis in the Murine Model of Immune-Mediated Bone Marrow Failure

Frontiers in Medicine, 2021
Background: Stanozolol and danazol are widely used in the treatment of aplastic anemia; however, their mechanisms of action are unclear.Methods: Bone marrow mononuclear cells from 10 patients newly diagnosed with aplastic anemia and 10 healthy volunteers
Hongmin Li, Zhangbiao Long, Tao Wang, Bing Han   +3 more
doaj   +1 more source

Granulocyte colony-stimulating factor receptors on granulocytes are down-regulated after endotoxin administration to healthy humans [PDF]

, 2000
Granulocyte colony-stimulating factor (G-CSF) is considered an important mediator of host defense against infection, and recombinant G-CSF is administered to patients with various infections.
Dekkers, P. E., Juffermans, N. P., van Deventer, S. J., van der Poll, T., de Jonge, E., van Deventer, S.J.H., ten Hove, T., Hove, T. t, Juffermans, N.P., Dekkers, P.E.P.   +9 more
core   +1 more source