Results 71 to 80 of about 51,381 (211)

Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival.

PLoS Biology, 2013
The dual specificity protein/lipid kinase, phosphoinositide 3-kinase (PI3K), promotes growth factor-mediated cell survival and is frequently deregulated in cancer.
Daniel Thomas, Jason A Powell, Benjamin D Green, Emma F Barry, Yuefang Ma, Joanna Woodcock, Stephen Fitter, Andrew C W Zannettino, Stuart M Pitson, Timothy P Hughes, Angel F Lopez, Peter R Shepherd, Andrew H Wei, Paul G Ekert, Mark A Guthridge   +14 more
doaj   +1 more source

CSF-1 as a regulator of macrophage activation and immune responses

, 2003
Macrophage activation is a key determinant of susceptibility and pathology in a variety of inflammatory diseases. The extent of macrophage activation is tightly regulated by a number of pro-inflammatory cytokines (e.g.
Sweet, MJ, Sweet, Matthew J, Hume, David A, Hume, DA   +3 more
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Modulation of cytokine release and neutrophil function by granulocyte colony-stimulating factor during endotoxemia in humans [PDF]

, 1997
In this double-blind, cross-over, placebo-controlled, randomized study, two groups of eight healthy male volunteers were challenged with endotoxin (4 ng/kg) on two occasions, once in conjunction with placebo and once with granulocyte colony-stimulating ...
Sander J.H. van Deventer, Annemieke Manten, Tiel-van Buul, M. M., van Deventer, S. J., Jaap Jansen, van der Poll, T., ten Cate, J. Wouter, Pajkrt, D., Tom van der Poll, Jan Wouter ten Cate, Jansen, J., Manten, A., Tiel-van Buul, M.M.C., Dasja Pajkrt, van Deventer, S.J.H., Monique M.C. Tiel-van Buul, ten Cate, J.W.   +16 more
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Differentiation of the mononuclear phagocyte system during mouse embryogenesis:the role of transcription factor PU.1

, 1999
During mouse embryogenesis, macrophage-like cells arise first in the yolk sac and are produced subsequently in the liver. The onset of liver hematopoiesis is associated with the transition from primitive to definitive erythrocyte production.
Lichanska, A M, Ostrowski, M C, Henkel, G W, Maki, R A, Murphy, K M, Browne, C M, Hume, D A, McKercher, S R   +7 more
core  

Monocyte-Derived Macrophages Are Impaired in Myelodysplastic Syndrome

Journal of Immunology Research, 2016
Background. The myelodysplastic syndrome (MDS) comprises a group of clonal hematopoietic stem cell diseases characterized by cytopenia, dysplasia in one or more of the major myeloid lineages, ineffective hematopoiesis, and increased risk of development ...
Yu Han, Huaquan Wang, Zonghong Shao
doaj   +1 more source

Effects of granulocyte-macrophage colony-stimulating factor and interleukin-3 on small cell lung cancer cells

, 1994
Nonhematopoietic malignant cells may express receptors for hematopoietic growth factors and respond to these peptides. The aim of the present study was to investigate whether small cell lung cancer (SCLC) cells may be stimulated to proliferate by ...
Pedrazzoli P., Bacciocchi G., Volpato G., Lazzaro A., Giordano M., Cazzola M., Zibera C., Bergamaschi G., Locatelli F., Cuna G. R. D., Gibelli N., Danova M., Pavesi L.   +12 more
core   +3 more sources

Mutations in the _SC4MOL_ gene encoding a novel methyl sterol oxidase cause autosomal recessive psoriasisiform dermatitis, microcephaly and developmental delay

, 2008
Disorders of cholesterol biosynthesis have clinical manifestations involving skeleton, eyes, neurologic development, and skin. We describe a patient with congenital cataracts, developmental delay, microcephaly, and low serum cholesterol who developed ...
Jushua Michel, Miao He, Jacqueline Hoover, Lisa Kratz, Laura Ferris, Gerard Vockley, Richard Kelley, Michael Gibson, Abbe Vallejo   +8 more
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Induction of lysosomal phospholipase A2 through the retinoid X receptor in THP-1 cells

Journal of Lipid Research, 2004
An acidic phospholipase A2 (LPLA2) was recently purified and cloned. THP-1 cells were used to characterize the gene induction of LPLA2. THP-1 cells were stimulated with several differentiation agents.
Akira Abe, Heather K. Poucher, Miki Hiraoka, James A. Shayman   +3 more
doaj   +1 more source

The regulation of haemopoietic stem cell and progenitor cell proliferation by humoral factors

, 2012
The mechanisms which regulate the growth fraction of the haemopoietic stem cell (CFU-S) and granulocyte macrophage progenitor cell (GM-CFC) have been investigated.
Cork, Michael John
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Acute radiation syndrome (ARS) – treatment of the reduced host defense

International Journal of General Medicine, 2012
Lars Heslet1, Christiane Bay2, Steen Nepper-Christensen31Serendex ApS, Gentofte; 2University of Copenhagen, Medical Faculty, Copenhagen; 3Department of Head and Neck Surgery, Otorhinolaryngology, Køge University Hospital, Køge ...
Heslet L, Bay C, Nepper-Christensen S
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