Results 41 to 50 of about 18,066 (161)

Analysis of the characteristics and management of perforated peptic ulcer from 2011 to 2022: A multicenter and retrospective descriptive study

Annals of Gastroenterological Surgery, Volume 9, Issue 3, Page 464-475, May 2025.
The in‐hospital mortality rate for perforated peptic ulcer in this study was 5.0%, and conservative treatment was safely performed even in elderly patients. As the perforation diameter increased, the rate of gastrectomy tended to rise, and the rate of anastomotic leakage in those patients was high.
Hiromasa Hoshi, Akira Endo, Koji Ito, Tomohiro Akutsu, Hikaru Odera, Hideto Shiraki, Kei Ito, Takeshi Yokoyama, Yasukazu Narita, Taro Masuda, Akira Suekane, Koji Morishita   +11 more
wiley   +1 more source

Sleep Disturbance and Chronic Urticaria: A Narrative Review of Its Relationship, Treatment and Evolving Literature

Health Science Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background and Aims Chronic Spontaneous Urticaria is characterized by the sudden onset of itchy wheals and angioedema and is primarily driven by mast cells. It can have a significant impact on the Quality of Life (QoL) of an individual. While the role of mast cells in urticaria is extensively described, the link between sleep disorders and ...
Asad Ullah Wasim, Sri Anugna Miriyala, Raymond Haward, Zeinab Hammoud, Pratik Agarwal, Nirja Kaka, Neil Patel, Yashendra Sethi, Poonam Gupta   +8 more
wiley   +1 more source

An overview of the non‐procedural treatment options for peripheral neuropathic pain

Muscle &Nerve, Volume 71, Issue 5, Page 791-801, May 2025.
Abstract Peripheral neuropathic pain is common in patients with peripheral nerve injury and can significantly impact both their function and quality of life. There is a wide variety of non‐interventional treatment approaches, including pharmacologic therapy, physical/occupational therapy, modalities (therapeutic, mechanical, thermal, etc.), psychology,
Evan R. Zeldin, Adam R. Goddard, Maxwell S. Boyle, Renee L. Madathil, Erick Rosenvall, Kajri A. Majithia, Eric J. Morrison   +6 more
wiley   +1 more source

Histamine increases neuronal excitability and sensitivity of the lateral vestibular nucleus and promotes motor behaviors via HCN channel coupled to H2 receptor [PDF]

, 2017
published_or_final_versio
Chan, YS, Chen, ZP, Li, B, Peng, XC, Wang, JJ, Yang, AH, Zhang, XY, Zhou, JY, Zhu, JN   +8 more
core   +1 more source

Molecular cloning of a gene encoding the histamine H2 receptor. [PDF]

Proceedings of the National Academy of Sciences, 1991
The H2 subclass of histamine receptors mediates gastric acid secretion, and antagonists for this receptor have proven to be effective therapy for acid peptic disorders of the gastrointestinal tract. The physiological action of histamine has been shown to be mediated via a guanine nucleotide-binding protein linked to adenylate cyclase activation and ...
Matthias Schäffer, Virginia Campbell, Craig D. Logsdon, John DelValle, Tadataka Yamada, Michael D. Uhler, Ira Gantz   +6 more
openaire   +5 more sources

Angelica dahurica Polysaccharides Ameliorate Colitis by Reducing the Restriction of Gut Microbiota‐Derived Imidazole Propionate on PPAR‐γ Signaling Activation

Phytotherapy Research, Volume 39, Issue 5, Page 2072-2090, May 2025.
ABSTRACT Angelica dahurica radix (ADR), the root of the botanical family Apiaceae (genus Angelica, species Angelica dahurica (Hoffm.)), has been used to treat colitis in clinical practice. The immunomodulatory effects of ADR are attributed to its polysaccharides (RP). However, its mechanism of action has not been elucidated.
Jingyi Hu, Feng Xu, Lei Zhu, Yuan Cui, Ryan Au, Yanan Li, Yiheng Tong, Hong Shen   +7 more
wiley   +1 more source

Lysergic acid diethylamide stimulates cardiac human H2 histamine and cardiac human 5-HT4-serotonin receptors [PDF]

Lysergic acid diethylamide (LSD) is an artificial hallucinogenic drug. Thus, we hypothesized that LSD might act 5-HT4 serotonin receptors and/or H2 histamine receptors.
Braekow, Pauline, Fehse, Charlotte, Gergs, Ulrich, Hofmann, Britt, Humphrys, Laura J., Jacob, Hannes, Kirchhefer, Uwe, Neumann, Joachim, Pockes, Steffen   +8 more
core   +1 more source

Impact of Exposure to Benzodiazepines on Adverse Effects and Efficacy of PD‐1/PD‐L1 Blockade in Patients With Non‐Small Cell Lung Cancer

Thoracic Cancer, Volume 16, Issue 9, May 2025.
The use of benzodiazepine receptor agonists (BZRAs) was linked to a reduced incidence of irAEs in patients with NSCLC receiving anti‐PD‐1/PD‐L1 monotherapy. However, among those who developed irAEs, BZRA use was associated with shorter PFS and OS. These findings suggest that while BZRAs may lower the incidence of irAEs, they could also diminish the ...
Kiyoshi Takagaki, Yoshiya Ohno, Taiichiro Otsuki, Aki Kubota, Takashi Kijima, Toshiyuki Tanaka   +5 more
wiley   +1 more source

Histamine, mast cells and tumour cell proliferation in breast cancer: does preoperative cimetidine administration have an effect? [PDF]

Endogenous histamine has been shown to effect growth mechanisms in experimental mammary carcinomas via H2 membrane receptors (Cricco et al, 1994). Both H1 and H2 binding sites are present in human mammary glands but only 75% malignant carcinomas express ...
Bolton, E, Bowrey, P F, King, J, Magarey, C, Marr, P, Morris, D L, Schwartz, P   +6 more
core   +2 more sources

Antihistaminergics and inverse agonism. Potential therapeutic applications [PDF]

, 2013
The accurate characterization of the molecular mechanisms involved in the action of receptor ligands is important for their appropriate therapeutic use and safety.
Davio, Carlos Alberto, Fernández, Natalia Brenda, Fitzsimons, Carlos, Monczor, Federico, Shayo, Carina Claudia   +4 more
core   +3 more sources