Results 11 to 20 of about 3,330,792 (348)

Evidence of variable human Fcγ receptor-Fc affinities across differentially-complexed IgG

mAbs, 2023
Antibody-mediated effector functions are widely considered to unfold according to an associative model of IgG-Fcγ receptor (FcγR) interactions. The associative model presupposes that Fc receptors cannot discriminate antigen-bound IgG from free IgG in ...
Andrew R. Crowley, Matthew R. Mehlenbacher, Mohammad M. Sajadi, Anthony L. DeVico, George K. Lewis, Margaret E. Ackerman   +5 more
doaj   +1 more source

The role of IgG Fc receptors in antibody-dependent enhancement

Nature reviews. Immunology, 2020
Antibody-dependent enhancement (ADE) is a mechanism by which the pathogenesis of certain viral infections is enhanced in the presence of sub-neutralizing or cross-reactive non-neutralizing antiviral antibodies.
S. Bournazos, Aaron Gupta, J. Ravetch
semanticscholar   +1 more source

IgG Suppresses Antibody Responses in Mice Lacking C1q, C3, Complement Receptors 1 and 2, or IgG Fc-Receptors. [PDF]

PLoS ONE, 2015
Antigen-specific IgG antibodies, passively administered to mice or humans together with large particulate antigens like erythrocytes, can completely suppress the antibody response against the antigen.
Joakim J E Bergström, Birgitta Heyman
doaj   +1 more source

Impact of estrogen on IgG glycosylation and serum protein glycosylation in a murine model of healthy postmenopause

Frontiers in Endocrinology, 2023
IntroductionThe glycosylation of immunoglobulin (Ig) G regulates IgG interaction capability with Fc gamma receptors found in all immune cells. In pathogenic conditions, estrogen can impact IgG levels and glycosylation.
Priti Gupta, Priti Gupta, Priti Gupta, Tibor Sághy, Tibor Sághy, Tibor Sághy, Jauquline Nordqvist, Jonas Nilsson, Hans Carlsten, Karin Horkeby, Petra Henning, Cecilia Engdahl, Cecilia Engdahl, Cecilia Engdahl   +13 more
doaj   +1 more source

C-Reactive Protein Enhances IgG-Mediated Cellular Destruction Through IgG-Fc Receptors in vitro

Frontiers in Immunology, 2021
Antibody-mediated blood disorders ensue after auto- or alloimmunization against blood cell antigens, resulting in cytopenia. Although the mechanisms of cell destruction are the same as in immunotherapies targeting tumor cells, many factors are still ...
A. Robin Temming, Matthias Tammes Buirs, Arthur E. H. Bentlage, Louise W. Treffers, Hannah Feringa, Steven W. de Taeye, Steven W. de Taeye, Taco W. Kuijpers, Taco W. Kuijpers, Sietse Q. Nagelkerke, Sietse Q. Nagelkerke, Giso Brasser, Juk Yee Mok, Wim J. E. van Esch, Timo K. van den Berg, Theo Rispens, C. Ellen van der Schoot, Gestur Vidarsson   +17 more
doaj   +1 more source

Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity

Science, 2020
A single sugar makes all the difference Antibodies are divided into several classes based on their nonvariable tail (Fc) domains. These regions interact with disparate immune cell receptors and complement proteins to help instruct distinct immune ...
M. Larsen, Erik L. de Graaf, M. Sonneveld, H. Plomp, J. Nouta, W. Hoepel, Hung-Jen Chen, Federica Linty, R. Visser, Maximilian Brinkhaus, Tonći Šuštić, S. D. de Taeye, A. Bentlage, S. Toivonen, C. Koeleman, S. Sainio, N. Kootstra, P. Brouwer, Chiara E. Geyer, N. Derksen, G. Wolbink, M. D. de Winther, R. Sanders, M. V. van Gils, S. de Bruin, Alexander P. J. Vlaar, T. Rispens, J. den Dunnen, H. Zaaijer, M. Wuhrer, C. Ellen van der Schoot, G. Vidarsson   +31 more
semanticscholar   +1 more source

Characterization of the Interaction between the Herpes Simplex Virus Type I Fc Receptor and Immunoglobulin G [PDF]

, 1999
Herpes simplex virus type I (HSV-1) virions and HSV-1-infected cells bind to human immunoglobulin G (hIgG) via its Fc region. A complex of two surface glycoproteins encoded by HSV-1, gE and gI, is responsible for Fc binding.
Bjorkman, Pamela J., Chapman, Tara L., Joseph, Ian M., Morrison, Sherie L., Raghavan, Malini, You, Il   +5 more
core   +1 more source

The Neonatal Fc Receptor (FcRn): A Misnomer?

Frontiers in Immunology, 2019
Antibodies are essential components of an adaptive immune response. Immunoglobulin G (IgG) is the most common type of antibody found in circulation and extracellular fluids.
Michal Pyzik, Kine M. K. Sand, Kine M. K. Sand, Jonathan J. Hubbard, Jonathan J. Hubbard, Jan Terje Andersen, Jan Terje Andersen, Inger Sandlie, Richard S. Blumberg, Richard S. Blumberg   +9 more
doaj   +1 more source

Antibody-Dependent Enhancement of SARS-CoV-2 Infection Is Mediated by the IgG Receptors FcγRIIA and FcγRIIIA but Does Not Contribute to Aberrant Cytokine Production by Macrophages

mBio, 2021
Viruses infect cells mainly via specific receptors at the cell surface. Antibody-dependent enhancement (ADE) of infection is an alternative mechanism of infection for viruses to infect immune cells that is mediated by antibodies and IgG receptors (FcγRs).
Tadashi Maemura, Makoto Kuroda, Tammy Armbrust, Seiya Yamayoshi, Peter J. Halfmann, Yoshihiro Kawaoka   +5 more
doaj   +1 more source

Contribution of human FcγRs to disease with evidence from human polymorphisms and transgenic animal studies

Frontiers in Immunology, 2014
The biological activities of human IgG antibodies predominantly rely on a family of receptors for the Fc portion of IgG, FcγRs: FcγRI, FcγRIIA, FcγRIIB, FcγRIIC, FcγRIIIA, FcγRIIIB, FcRL5, FcRn and TRIM21.
Caitlin Margaret Gillis, Caitlin Margaret Gillis, Aurélie eGouel-Chéron, Aurélie eGouel-Chéron, Aurélie eGouel-Chéron, Friederike eJönsson, Friederike eJönsson, Pierre eBruhns, Pierre eBruhns   +8 more
doaj   +1 more source