Impact of Plasma Membrane Domains on IgG Fc Receptor Function
Frontiers in Immunology, 2020 Lipid cell membranes not only represent the physical boundaries of cells. They also actively participate in many cellular processes. This contribution is facilitated by highly complex mixtures of different lipids and incorporation of various membrane ...
Sibel Kara +12 more
doaj +1 more source
Affinity of human IgG subclasses to mouse Fc gamma receptors
mAbs, 2017 Human IgG is the main antibody class used in antibody therapies because of its efficacy and longer half-life, which are completely or partly due to FcγR-mediated functions of the molecules.
G. Dekkers +7 more
semanticscholar +1 more source
IgE and IgG Antibodies as Regulators of Mast Cell and Basophil Functions in Food Allergy
Frontiers in Immunology, 2020 Food allergy is a major health issue, affecting the lives of 8% of U.S. children and their families. There is an urgent need to identify the environmental and endogenous signals that induce and sustain allergic responses to ingested allergens.
C. Kanagaratham +3 more
semanticscholar +1 more source
New roles for Fc receptors in neurodegeneration-the impact on immunotherapy for Alzheimer's disease [PDF]
, 2014 There are an estimated 18 million Alzheimer's disease (AD) sufferers worldwide and with no disease modifying treatment currently available, development of new therapies represents an enormous unmet clinical need.
Fuller, James P. +2 more
core +3 more sources
Essential role of NK cells in IgG therapy for experimental autoimmune encephalomyelitis.
PLoS ONE, 2013 Intravenous immunoglobulin has long been used in treating autoimmune diseases, although mechanisms remain uncertain. Activating Fcγ receptors are receptors of IgG and reported to be essential in intravenous immunoglobulin (IVIG) therapy.
Wai Po Chong +7 more
doaj +1 more source
Receptor-mediated transport of IgG. [PDF]
The Journal of cell biology, 1984 The intestinal epithelium of the neonatal rat is a model system for the study of receptor-mediated endocytosis in which large amounts of IgG are transferred intact across polarized cells. This review summarizes the ultrastructural pathway followed by IgG during cellular transit and several important properties of the membrane receptor that recognizes ...
R, Rodewald, J P, Kraehenbuhl
openaire +2 more sources
Protection and mechanism of action of a novel human respiratory syncytial virus vaccine candidate based on the extracellular domain of small hydrophobic protein [PDF]
, 2014 Infections with human respiratory syncytial virus (HRSV) occur globally in all age groups and can have devastating consequences in young infants. We demonstrate that a vaccine based on the extracellular domain (SHe) of the small hydrophobic (SH) protein ...
Bert Schepens +20 more
core +3 more sources
IgG Subclasses and Allotypes: From Structure to Effector Functions
Frontiers in Immunology, 2014 Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains.
G. Vidarsson, G. Dekkers, T. Rispens
semanticscholar +1 more source
Induction of MET Receptor Tyrosine Kinase Down-Regulation through Antibody-Mediated Receptor Clustering [PDF]
, 2019 The proto-oncoprotein MET is a receptor tyrosine kinase that plays a key role in cancer cell growth and invasion. We have used fluorescence-tagged antibodies to activate MET in live serum-starved glioblastoma cells and monitor the fate of antibody-bound ...
Adam Dick +4 more
core +3 more sources
Immunomodulation by IVIg and the role of Fc-gamma receptors: classic mechanisms of action after all?
Frontiers in Immunology, 2015 Intravenous IgG (IVIg) contains polyclonal IgG from thousands of donors. It is administered at a low dose at regular intervals as antibody replacement therapy and at a higher dose as immunomodulatory treatment in various auto-immune or auto-inflammatory ...
Sietse Quirijn Nagelkerke +2 more
doaj +1 more source