Neonatal Fc receptor and IgG-based therapeutics [PDF]
mAbs, 2011 The majority of potent new biologics today are IgG-based molecules that have demonstrated tissue-targeting specificity with favorable clinical response. Several factors determine the efficacy of these products, including target specificity, serum half-life and effector functions via complement-dependent cytotoxicity, antibody-dependent cell-mediated ...
Timothy T, Kuo, Victoria G, Aveson
openaire +2 more sources
Liver Transplantation to Provide Low-Density-Lipoprotein Receptors and Lower Plasma Cholesterol in a Child with Homozygous Familial Hypercholesterolemia [PDF]
, 1984 A six-year-old girl with severe hypercholesterolemia and atherosclerosis had two defective genes at the low-density-lipoprotein (LDL) receptor locus, as determined by biochemical studies of cultured fibroblasts.
Cummings +9 more
core +1 more source
New immunolatex spheres: visual markers of antigens on lymphocytes for scanning electron microscopy [PDF]
, 1975 New immunochemical reagents consisting of antibodies bound to small latex spheres were used as visual markers for the detection and localization of cell surface antigens by scanning electron microscopy.
Dreyer, William J. +3 more
core +2 more sources
The role of FcRn in antigen presentation
Frontiers in Immunology, 2014 Immunoglobulins are unique molecules capable of simultaneously recognizing a diverse array of antigens and themselves being recognized by a broad array of receptors. The abundance specifically of the IgG subclass and the variety of signaling receptors to
Kristi eBaker +4 more
doaj +1 more source
Modulation of apoprotein E secretion in response to receptor-mediated endocytosis in resident and inflammatory macrophages. [PDF]
, 1984 We have determined the effect of various endocytic ligands on the secretion of ApoE by macrophages. ApoE was a major secreted protein of resident macrophages, but BCG-activated macrophages secreted little ApoE and periodate-elicited macrophages secreted ...
Takemura, R, Werb, Z
core +2 more sources
FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodies
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Transport of IgG antibodies from the maternal to the fetal circulation is a key process for neonatal immunity, as neonates cannot sufficiently generate IgG antibodies to reach protective levels during the first months after birth.
Sara Borghi +11 more
semanticscholar +1 more source
IgG Isolated from LP-BM5 Infected Mouse Brain Activates Ionotropic Glutamate Receptors
Neurobiology of Disease, 2001 Biochemical and immunological studies have shown that mice infected with LP-BM5 virus develop antibodies to ionotropic glutamate receptors. Here, IgG isolated from brain of infected mice has been tested electrophysiologically on cultured rat cortical and
Anthony S. Basile +5 more
doaj +1 more source
A Comparison of Natural and Therapeutic Anti-IgE Antibodies
AntibodiesImmunoglobulin E (IgE) plays a critical role for the immune system, fighting against parasites, toxins, and cancer. However, when it reacts to allergens without proper regulation, it can cause allergic reactions, including anaphylaxis, through a process ...
Monique Vogel, Paul Engeroff
doaj +1 more source
Polymorphisms in Fc Gamma Receptors and Susceptibility to Malaria in an Endemic Population
Frontiers in Immunology, 2020 Repeated infections by Plasmodium falciparum result in a humoral response that could reduce disease symptoms and prevent the development of clinical malaria.
Mireille Ahou Amiah +6 more
doaj +1 more source
Fc Gamma Receptors and Their Role in Antigen Uptake, Presentation, and T Cell Activation
Frontiers in Immunology, 2020 The cellular uptake, intracellular processing, and presentation of foreign antigen are crucial processes for eliciting an effective adaptive host response to the majority of pathogens.
F. Junker, J. Gordon, O. Qureshi
semanticscholar +1 more source