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Immunology Today, 1989
The diverse biological activities of interleukin 1 (IL-1) have attracted interest from a wide range of biological disciplines ~ After systemic injection into a variety of animals, it seems that IL-1 affects nearly every organ system. Interested parties fall into two groups: those studying the potential beneficial effects of IL-1 on host defense ...
Burton D. Clark +4 more
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The diverse biological activities of interleukin 1 (IL-1) have attracted interest from a wide range of biological disciplines ~ After systemic injection into a variety of animals, it seems that IL-1 affects nearly every organ system. Interested parties fall into two groups: those studying the potential beneficial effects of IL-1 on host defense ...
Burton D. Clark +4 more
openaire +3 more sources
Immunology Today, 1987
One of the pivotal events in the initiation of inflammatory responses is activation of both resident tissue macrophages at the site of damage and circulating monocytes infiltrating the area. The activated macrophages release a group of factors which influence inflammation and tissue regulation.
David L. Urdal, Steven K. Dower
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One of the pivotal events in the initiation of inflammatory responses is activation of both resident tissue macrophages at the site of damage and circulating monocytes infiltrating the area. The activated macrophages release a group of factors which influence inflammation and tissue regulation.
David L. Urdal, Steven K. Dower
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The interleukin-1 receptor family
Seminars in Immunology, 2006The cytokines IL-1 and IL-18 are key molecules both in the innate and in the adaptive immune response. Their activity is mediated by specific receptors present on the membrane of target cells. It has become apparent that these receptors are members of a larger family of related receptors, most of which are apparently involved in the mechanisms of host ...
Boraschi D, Tagliabue A
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The family of the interleukin‐1 receptors
Immunological Reviews, 2017SummaryThe extracellular forms of the IL‐1 cytokines are active through binding to specific receptors on the surface of target cells. IL‐1 ligands bind to the extracellular portion of their ligand‐binding receptor chain. For signaling to take place, a non‐binding accessory chain is recruited into a heterotrimeric complex.
Boraschi +4 more
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The interleukin 1 receptor family
Developmental & Comparative Immunology, 2004Interleukin-1 is a key inflammatory cytokine that mediates its effects through a type I receptor and a receptor accessory protein. These two molecules are members of a wider family of proteins that have in common the presence of immunoglobulin domains in the extracellular region of the protein and a TIR domain in the cytoplasmic region.
Charles E. Cunningham +2 more
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1995
Abstract The human type I IL-1 receptor is predicted from the cDNA sequence to be a protein of 569 amino acids (GenBank accession number M27492; mouse, M20658; rat, M95578; chicken, M81846) (Sims et al. 1989). It contains a 20-aminoacid signal peptide, an extracellular region of 317 amino acids, a single 22-amino-acid transmembrane ...
J E, Sims, S K, Dower
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Abstract The human type I IL-1 receptor is predicted from the cDNA sequence to be a protein of 569 amino acids (GenBank accession number M27492; mouse, M20658; rat, M95578; chicken, M81846) (Sims et al. 1989). It contains a 20-aminoacid signal peptide, an extracellular region of 317 amino acids, a single 22-amino-acid transmembrane ...
J E, Sims, S K, Dower
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INTERLEUKIN-1 RECEPTOR ANTAGONIST
Rheumatic Disease Clinics of North America, 1998There are three members of the IL-1 gene family: IL-1 alpha, IL-1 beta, and IL-1ra, IL-1 alpha, and IL-1 beta are both antagonist molecules with many proinflammatory effects. IL-1ra is an antagonist molecule that can inhibit the effect of IL-1 alpha and IL-1 beta by specifically blocking the IL-1 receptor on target effector cells.
Gaye Cunnane, Barry Bresnihan
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