Results 21 to 30 of about 475,125 (292)

Dataset on characterization of recombinant interleukin-23α, IL-12p40 and IL-23 complex protein, which activates JAK-STAT signaling pathway in chicken cell lines using immunocytochemical staining

Data in Brief, 2018
The data herein is related to the research article entitled “Functional analyses of the interaction of chicken interleukin 23 subunit p19 with IL-12 subunit p40 to form the IL-23 complex” [1] where we demonstrated that the chicken interleukin (IL)-23α ...
Anh Duc Truong, Cong Thanh Hoang, Yeojin Hong, Janggeun Lee, Kyungbaek Lee, Hyun S. Lillehoj, Yeong Ho Hong   +6 more
doaj   +1 more source

Dysregulation of Lymphocyte Interleukin-12 Receptor Expression in Sézary Syndrome [PDF]

Journal of Investigative Dermatology, 2001
Initial phase I and II clinical trials with recombinant human interleukin-12 have demonstrated the therapeutic efficacy of this cytokine in early stage cutaneous T cell lymphoma as compared with more advanced stages such as the leukemic Sézary syndrome.
Zaki, Mohamed H., Shane, Ryan B., Geng, Yuemei, Showe, Louise C., Everetts, Suzanne E., Presky, David H., Wysocka, Maria, Moore, Jonni S., Rook, Alain H.   +8 more
openaire   +2 more sources

Interleukin-1 blockade in heart failure with preserved ejection fraction: rationale and design of the Diastolic Heart Failure Anakinra Response Trial 2 (D-HART2) [PDF]

, 2017
Heart failure with preserved ejection fraction (HFpEF) now accounts for the majority of con-firmed HF cases in the United States. However, there are no highly effective evidence-basedtreatments currently available for these patients.
Abbate, Antonio, Abouzaki, Nayef, Arena, Ross, Biondi-zoccai, Giuseppe, Buckley, Leo F., Canada, Justin M., Carbone, Salvatore, Dixon, Dave L., Oddi-erdle, Claudia, Trankle, Cory R., Van Tassell, Benjamin W.   +10 more
core   +1 more source

Interleukin-18 Increases TLR4 and Mannose Receptor Expression and Modulates Cytokine Production in Human Monocytes

Mediators of Inflammation, 2015
Interleukin-18 is a proinflammatory cytokine belonging to the interleukin-1 family of cytokines. This cytokine exerts many unique biological and immunological effects.
Luciane Alarcão Dias-Melicio, Reginaldo Keller Fernandes, Daniela Ramos Rodrigues, Marjorie Assis Golim, Angela Maria Victoriano Campos Soares   +4 more
doaj   +1 more source

Cellular networks controlling Th2 polarization in allergy and immunity [PDF]

, 2012
In contrast to the development of Th1 (type 1 T helper cells), Th17 and Treg (regulatory T cells), little is known of the mechanisms governing Th2 development, which is important for immunity to helminths and for us to understand the pathogenesis of ...
Kool, Mirjam, Hammad, Hamida, Lambrecht, Bart   +2 more
core   +1 more source

Inhibition of IL-12 heterodimers impairs TLR9-mediated prevention of early mouse plasmacytoma cell growth

Frontiers in Medicine, 2023
IntroductionNatural prevention of cancer development depends on an efficient immunosurveillance that may be modulated by environmental factors, including infections.
Mohamed F. Mandour, Mohamed F. Mandour, Pyone Pyone Soe, Pyone Pyone Soe, Anne-Sophie Castonguay, Anne-Sophie Castonguay, Jacques Van Snick, Jacques Van Snick, Jean-Paul Coutelier, Jean-Paul Coutelier   +9 more
doaj   +1 more source

Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]

, 2011
Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle, Lieselotte eVande Walle, Mohamed eLamkanfi, Mohamed eLamkanfi   +3 more
core   +2 more sources

Total RNA and genomic DNA of Lactobacillus gasseri OLL2809 induce interleukin-12 production in the mouse macrophage cell line J774.1 via toll-like receptors 7 and 9

BMC Microbiology, 2020
Background Lactobacillus gasseri OLL2809 can highly induce interleukin (IL)-12 production in immune cells. Even though beneficial properties of this strain for both humans and animals have been reported, the mechanism by which the bacteria induces the ...
Kazumasa Onishi, Junko Mochizuki, Asako Sato, Ayako Goto, Toshihiro Sashihara   +4 more
doaj   +1 more source

Interleukin‐12 Receptor β1 Deficiency in a Patient with Abdominal Tuberculosis [PDF]

The Journal of Infectious Diseases, 2001
Two siblings with interleukin-12 receptor beta1 (IL-12Rbeta1) deficiency but different clinical phenotypes were studied. Both are homozygous for an IL12RB1 missense mutation that prevents receptor expression and abolishes cellular responses to IL-12.
F, Altare, A, Ensser, A, Breiman, J, Reichenbach, J E, Baghdadi, A, Fischer, J F, Emile, J L, Gaillard, E, Meinl, J L, Casanova   +9 more
openaire   +2 more sources

Polymorphisms in genes of interleukin 12 and its receptors and their association with protection against severe malarial anaemia in children in western Kenya

Malaria Journal, 2010
Background Malarial anaemia is characterized by destruction of malaria infected red blood cells and suppression of erythropoiesis. Interleukin 12 (IL12) significantly boosts erythropoietic responses in murine models of malarial anaemia and decreased IL12
Slutsker Laurence, Lal Altaf A, Terlouw Dianne, Nahlen Bernard, Kariuki Simon, ter Kuile Feiko, Crawford Sara, Eng Jodi, Prather Donald, Zhang Lyna, Udhayakumar Venkatachalam, Shi Ya   +11 more
doaj   +1 more source