Results 31 to 40 of about 475,125 (292)

The interleukin-12 and interleukin-12 receptor system in normal and transformed human B lymphocytes.

Haematologica, 2002
Interleukin-12 (IL-12) is a heterodimeric cytokine that induces interferon-g (IFN-g) production by natural killer and T-lymphocytes. IL-12 also activates human B-cells through the IL-12 receptor (IL-12R) complex. Here we review the expression and function of IL-12 and IL-12R in human B-cells and in their malignant counterparts.The information provided ...
Irma, Airoldi, Roberta, Guglielmino, Giuseppe, Carra, Anna, Corcione, Franca, Gerosa, Giuseppe, Taborelli, Giorgio, Trinchieri, Vito, Pistoia   +7 more
openaire   +2 more sources

Staphylococcus aureus enterotoxin B regulates prostaglandin E-2 synthesis, growth, and migration in nasal tissue fibroblasts [PDF]

, 2008
Background. Superantigens and eicosanoids are important amplifiers and regulators of inflammation in airway diseases. We therefore studied the possible influence of Staphylococcus aureus enterotoxin B ( SEB) on the cyclooxygenase ( COX) pathway and basic
Bachert, Claus, Claeys, Cindy, Perez Novo, Claudina, Van Cauwenberge, Paul, Waeytens, Anouk   +4 more
core   +2 more sources

Dendritic Cells as Danger-Recognizing Biosensors

Sensors, 2009
Dendritic cells (DCs) are antigen presenting cells that are characterized by a potent capacity to initiate immune responses. DCs comprise several subsets with distinct phenotypes.
Seokmann Hong, Wooseok Im, Mia Gi
doaj   +1 more source

Integrated Analysis of circRNA-miRNA-mRNA Regulatory Networks in the Intestine of Sebastes schlegelii Following Edwardsiella tarda Challenge

Frontiers in Immunology, 2021
Sebastes schlegelii, an important aquaculture species, has been widely cultured in East Asian countries. With the increase in the cultivation scale, various diseases have become major threats to the industry.
Min Cao, Xu Yan, Baofeng Su, Ning Yang, Qiang Fu, Ting Xue, Lin Song, Qi Li, Chao Li   +8 more
doaj   +1 more source

Cyclin G associated kinase interacts with interleukin 12 receptor β2 and suppresses interleukin 12 induced IFN‐γ production

FEBS Letters, 2007
Interleukin 12 receptor β1 (IL‐12Rβ1) and β2 (IL‐12Rβ2) constitute the functional and high‐affinity receptor complex for interleukin 12 (IL‐12) and mediate important functions in activated T cells. In this study, we identified cyclin G associated kinase (GAK) as a new IL‐12Rβ2‐interacting protein using yeast two‐hybrid system and confirmed it by ...
Lin, Ying, Tang, Yu Jie, Zong, Hong Liang, Gu, Jian Xin, Deng, Wei Wen, Wang, Chen, Sun, Bing   +6 more
openaire   +3 more sources

Perivascular adipose tissue inflammation in vascular disease [PDF]

, 2017
Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in volume and becomes dysfunctional, with altered cellular composition and molecular ...
Guzik, Tomasz J., Nosalski, Ryszard
core   +1 more source

Effects of restraint stress on the regulation of hippocampal glutamate receptor and inflammation genes in female C57BL/6 and BALB/c mice

Neurobiology of Stress, 2019
The two strains of inbred mice, BALB/c and C57BL/6, are widely used in pre-clinical psychiatry research due to their differences in stress susceptibility.
Joshua McWhirt, Monica Sathyanesan, Dayalan Sampath, Samuel S. Newton   +3 more
doaj   +1 more source

IL-12Rβ1 deficiency corresponding to concurrency of two diseases, mendelian susceptibility to mycobacterial disease and Crohn's disease

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2019
Background: The interleukin-12 receptor β1 (IL-12Rβ1) deficiency is a primary immunodeficiency (PID), affecting the immunological pathway of interleukin 12/interferon- γ (IL12/IFN-γ) axis and interleukin 23 receptor (IL23R).
Razieh Khoshnevisan, Nioosha Nekooei-marnany, Christoph Klein, Daniel Kotlarz, Mahdieh Behnam, Vajihe Ostadi, Majid Yaran, Abbas Rezaei, Roya Sherkat   +8 more
doaj   +1 more source

Effector Functions of Natural Killer Cell Subsets in the Control of Hematological Malignancies. [PDF]

, 2015
Treatment of hematological malignant disorders has been improved over the last years, but high relapse rate mainly attributable to the presence of minimal residual disease still persists.
Biassoni, Biron, Björklund, Brodin, Bryceson, Burns, Campbell, Cooley, Cooper, Cooper, Curti, Davies, Di Santo, Di Santo, Farag, Fehniger, Fogler, Foley, Freud, Gasser, Gilfillan, Grimm, Guethlein, Herberman, Huntington, Joncker, Kiessling, Killig, King, Kröger, Lajoie, Lanier, Leong, Ljunggren, Lowe, Lundqvist, Mancusi, McQueen, Miller, Moretta, Moretta, Moretta, Nguyen, Oevermann, Ouyang, Perussia, Phillips, Romagnani, Romee, Rosenberg, Rosenberg, Rosenberg, Ruggeri, Santoni, Stabile, Stabile, Stern, Stringaris, Thielens, Torelli, Trinchieri, Trinchieri, Vago, Valés-Gómez, Venstrom, Vivier, Whitelaw, Zorn   +67 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source