Results 11 to 20 of about 439,419 (286)

Interleukin-17 Receptor D in Physiology, Inflammation and Cancer [PDF]

Frontiers in Oncology, 2021
Interleukin-17 receptor D (IL-17RD) is an evolutionarily conserved member of the IL-17 receptor family. Originally identified as a negative regulator of fibroblast growth factor (FGF) signaling under the name of Sef (Similar expression to FGF genes), IL-17RD was subsequently reported to regulate other receptor tyrosine kinase signaling pathways.
Charlotte Girondel, Charlotte Girondel, Sylvain Meloche, Sylvain Meloche, Sylvain Meloche   +4 more
openaire   +6 more sources

SELEX-discovered aptamer that inhibits cellular interleukin-17/interleukin-17 receptor interaction and antagonizes interleukin-17 signaling

Bioscience, Biotechnology, and Biochemistry, 2023
ABSTRACT This research is based on a Systematic Evolution of Ligands by EXponential enrichment, also referred to as in vitro selection against the extracellular domain of human interleukin-17 receptor A (IL-17RA). Pull-down assay via quantitative polymerase chain reaction and chemiluminescence detection showed that the cloned RNA with ...
Arifur Rahman Munshi, Tong Wang, Yukio Takamori, Takehiro Ando, Takumi Yokoyama, Daisuke Fuji, Zhehao Xu, Santhana Vedi, Mizuki Yamamoto, Keita Tsukamoto, Takashi Kawakami   +10 more
openaire   +2 more sources

MicroRNAs and other mechanisms regulate interleukin-17 cytokines and receptors [PDF]

Frontiers in Bioscience, 2012
Interleukin-17 cytokines are a family of pro-inflammatory cytokines. Our current studies found: i) IL-17 cytokines are not ubiquitously expressed, but several receptors and TRAF3IP2 are ubiquitously expressed in tissues with a few exceptions; ii) heart and vascular tissue are in the second tier of readiness to respond to IL-17 cytokine stimulation; iii)
Jietang, Mai, Anthony, Virtue, Erin, Maley, Tran, Tran, Ying, Yin, Shu, Meng, Meghana, Pansuria, Xiaohua, Jiang, Hong, Wang, Xiao-Feng, Yang   +9 more
openaire   +3 more sources

Structural basis of receptor sharing by interleukin 17 cytokines [PDF]

Nature Immunology, 2009
Interleukin 17 (IL-17)-producing helper T cells (T(H)-17 cells), together with their effector cytokines, including members of the IL-17 family, are emerging as key mediators of chronic inflammatory and autoimmune disorders. Here we present the crystal structure of a complex of IL-17 receptor A (IL-17RA) bound to IL-17F in a 1:2 stoichiometry.
Ely, Lauren K., Fischer, Suzanne, Garcia, K. Christopher   +2 more
openaire   +2 more sources

Impact of Adalimumab Treatment on Interleukin-17 and Interleukin-17 Receptor Expression in Skin and Synovium of Psoriatic Arthritis Patients with Mild Psoriasis

Biomedicines, 2022
Interleukin (IL)-17 and tumor necrosis factor-alpha (TNF)-α are key players in psoriatic arthritis (PsA) pathogenesis. While both cytokines can be therapeutically targeted with beneficial clinical outcome, it is unclear whether inhibiting one cytokine ...
Janne W. Bolt, Arno W. van Kuijk, Marcel B. M. Teunissen, Dennis van der Coelen, Saïda Aarrass, Daniëlle M. Gerlag, Paul P. Tak, Marleen G. van de Sande, Maria C. Lebre, Lisa G. M. van Baarsen   +9 more
doaj   +1 more source

Virus-Like Particle-Mediated Vaccination against Interleukin-13 May Harbour General Anti-Allergic Potential beyond Atopic Dermatitis [PDF]

, 2020
Virus-like particle (VLP)-based anti-infective prophylactic vaccination has been established in clinical use. Although validated in proof-of-concept clinical trials in humans, no VLP-based therapeutic vaccination against self-proteins to modulate chronic
Foerster, John, Molęda, Aleksandra
core   +2 more sources

Targeting interleukin-17 receptors

Oncotarget, 2015
During the last decade, increasing evidence suggests a strong association between chronic inflammation and cancer development among different types of cancer. The dysregulation of pro-inflammatory cytokines or their receptors is a common feature observed in many cancers [1]. Cancer cells take advantage of cytokine or cytokine receptor overexpression to
Wen-Hwa, Lee, Heng-Hsiung, Wu, Chun-Kai, Huang   +2 more
openaire   +2 more sources

Interleukin-25 Produced by Synoviocytes Has Anti-inflammatory Effects by Acting As a Receptor Antagonist for Interleukin-17A Function

Frontiers in Immunology, 2017
The production and function of cytokines are highly regulated. One mechanism is the balance between pro- and anti-inflammatory cytokines. As interleukin (IL)-17A and IL-25 share the IL-17RA receptor chain, we hypothesize that IL-25 acts as an IL-17A ...
Fabien Lavocat, Ndiémé Ndongo-Thiam, Pierre Miossec   +2 more
doaj   +1 more source

Increased IL-23R+ Th Cells Population Exhibits Higher SLEDAI-2K Scores in Systemic Lupus Erythematosus Patients

Frontiers in Immunology, 2021
The IL-23/IL-17 axis plays causative roles in the development and progression of systemic lupus erythematosus (SLE). However, it remains unclear if the IL-17RA+ and IL-23R+ T helper (Th) cells populations are associated with the serum IL-17 and IL-23 ...
Aziz Farah Izati, Aziz Farah Izati, Nur Diyana Mohd Shukri, Nur Diyana Mohd Shukri, Wan Syamimee Wan Ghazali, Wan Syamimee Wan Ghazali, Che Maraina Che Hussin, Che Maraina Che Hussin, Kah Keng Wong, Kah Keng Wong   +9 more
doaj   +1 more source

Downregulation of Chicken Interleukin-17 Receptor A during Eimeria Infection [PDF]

Infection and Immunity, 2014
ABSTRACT Both interleukin-17A (IL-17A) and IL-17F are proinflammatory cytokines that have an important role in intestinal homeostasis via receptor signaling. These cytokines have been characterized in chickens, but very little is known about their receptors and their functional activity.
Woo H, Kim, Jipseol, Jeong, Ae R, Park, Dongjean, Yim, Suk, Kim, Hong H, Chang, Seung-Hak, Yang, Dong-Hee, Kim, Hyun S, Lillehoj, Wongi, Min   +9 more
openaire   +2 more sources