Results 21 to 30 of about 439,419 (286)
The evolution of IL-4 and IL-13 and their receptor subunits [PDF]
, 2015 Peer ...
Secombes, Christopher J., Wang, Tiehui
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Clinical significance of Interleukin 17 receptor E in diabetic nephropathy
International Immunopharmacology, 2023 Diabetic nephropathy (DN) is a leading cause of end-stage renal disease. Since there are limited therapeutic options available for the prevention of DN progression, it is imperative to explore novel differentially expressed genes and therapeutic targets for DN.In this study, mice kidney tissue were subjected to transcriptome sequencing and the results ...
Jingjing Wang +5 more
openaire +2 more sources
TRAF Regulation of IL-17 Cytokine Signaling
Frontiers in Immunology, 2019 Tumor necrosis factor receptor (TNFR)-associated factors or (TRAFs) are important mediators of Interleukin-17 (IL-17) cytokine signaling and contribute to driving tissue responses that are crucial for protective immunity but are often implicated in ...
Shadi Swaidani +5 more
doaj +1 more source
MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice [PDF]
, 2012 Commensal bacterial sensing by Toll-like receptors is critical for maintaining intestinal homeostasis, but can lead to colitis in the absence of interleukin-10. Although Toll-like receptors are expressed in multiple cell types in the colon, the cell type(
Flavell, Richard A. +10 more
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Veterinary Integrative Sciences, 2021 Interleukin-17 receptor A (IL17RA) is one of the cytokine receptors of the pro-inflammatory interleukin-17 (IL17) cytokine family. The IL17 and IL17RA genes are involved in inflammatory and immune responses as well as reproductive process of ...
Worrarak Norseeda +6 more
doaj +1 more source
Cellular networks controlling Th2 polarization in allergy and immunity [PDF]
, 2012 In contrast to the development of Th1 (type 1 T helper cells), Th17 and Treg (regulatory T cells), little is known of the mechanisms governing Th2 development, which is important for immunity to helminths and for us to understand the pathogenesis of ...
Kool, Mirjam +2 more
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Cutting Edge: Interleukin 17 Signals through a Heteromeric Receptor Complex [PDF]
The Journal of Immunology, 2006 AbstractIL-17 is an inflammatory cytokine produced primarily by a unique lineage of CD4 T cells that plays critical roles in the pathogenesis of multiple autoimmune diseases. IL-17RA is a ubiquitously expressed receptor that is essential for IL-17 biologic activity.
Dean, Toy +7 more
openaire +2 more sources
Essential role of NK cells in IgG therapy for experimental autoimmune encephalomyelitis.
PLoS ONE, 2013 Intravenous immunoglobulin has long been used in treating autoimmune diseases, although mechanisms remain uncertain. Activating Fcγ receptors are receptors of IgG and reported to be essential in intravenous immunoglobulin (IVIG) therapy.
Wai Po Chong +7 more
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The IL-17 family in diseases: from bench to bedside
Signal Transduction and Targeted Therapy, 2023 The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and recently, all of its related receptors have been discovered. IL-17 was first discovered approximately 30 years ago.
Longjie Huangfu +3 more
doaj +1 more source
BMC Anesthesiology, 2022 Background Dexmedetomidine (DEX) is a selective agonist of α2-adrenergic receptors with anesthetic activity and neuroprotective benefits. However, its mechanism of action at the molecular level remains poorly defined.
Liangyuan Suo, Mingyu Wang
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