Results 41 to 50 of about 439,419 (286)

Interleukin‐17 sensitizes joint nociceptors to mechanical stimuli and contributes to arthritic pain through neuronal interleukin‐17 receptors in rodents [PDF]

Arthritis & Rheumatism, 2012
AbstractObjectiveInterleukin‐17 (IL‐17) is considered a proinflammatory cytokine, but whether neuronal IL‐17 receptors contribute to the generation of arthritic pain is unknown. This study was undertaken to explore whether IL‐17A acts on neurons, whether it sensitizes joint nociceptors, and whether neutralization of IL‐17 is antinociceptive.MethodsWe ...
Frank, Richter, Gabriel, Natura, Matthias, Ebbinghaus, Gisela Segond, von Banchet, Susanne, Hensellek, Christian, König, Rolf, Bräuer, Hans-Georg, Schaible   +7 more
openaire   +2 more sources

Interleukin-17 receptor antagonist reduces inflammatory response in experimental periodontitis

International Dental Journal, 2023
Aim or Purpose: Interleukin (IL)-17 is one of the inflammatory cytokines caused periodontitis and psoriasis. Psoriasis, a chronic inflammatory skin disease, treats with IL-17 receptor antagonist (brodalumab: BRD). However, little is known about the effect of BRD on periodontitis.
Dr Takenori Sato, Dr. Keisuke Handa
openaire   +2 more sources

Interleukin-17 family in health and immune diseases: From origin to clinical implications

Neural Regeneration Research
The interleukin-17 family is the key group of cytokines and displays a broad spectrum of biological functions, including regulating the inflammatory cascade in various autoimmune and inflammatory diseases, such as multiple sclerosis, neuromyelitis optica
Guozhen Deng, Mengdi Guo, Jiahui Fan, Weiyan Wang, Mei-Ling Jiang, Cun-Jin Zhang   +5 more
doaj   +1 more source

Interleukin 17 Receptor a Haplotype Analysis in Chronic Spontaneous Urticaria [PDF]

, 2020
Abstract Background: Chronic spontaneous urticaria (CSU) is a distressing skin disease. Family clustering and heterogeneity in the onset and progression indicate that susceptibility to CSU is a complex trait. In this study, we performed haplotype analysis for one of the key player gene, IL17RA, for CSU to test the association with disease ...
Hesham Nada, Ranya Hassan, Rasha Abd El-Hamed Ibrahim, Omnia Emad Abdelsalam, Amal Fathy, Eman A Toraih, Mona Atwa   +6 more
openaire   +1 more source

Enhanced Th17 Responses in Patients with Autoimmune Hepatitis

Middle East Journal of Digestive Diseases, 2019
BACKGROUND T cells are major players in chronic inflammatory diseases such as autoimmune hepatitis (AIH). However, it is not clear which subset of T cells participates in the pathophysiology of the disease.
Farinaz Behfarjam, Siavash Nasseri-Moghaddam, Zohreh Jadali   +2 more
doaj   +1 more source

Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance [PDF]

, 2012
INTRODUCTION Endosomal toll-like receptors (TLRs) have recently emerged as potential contributors to the inflammation observed in human and rodent models of rheumatoid arthritis (RA).
Alzabin, Saba, Kong, Philip, Medghalchi, Mino, Palfreeman, Andrew, Sacre, Sandra, Williams, Richard   +5 more
core   +1 more source

Exploring causal associations between interleukins, their receptors, and acute respiratory distress syndrome: a bidirectional-Mendelian Randomization study

Frontiers in Genetics
BackgroundAcute Respiratory Distress Syndrome (ARDS) is a severe lung condition posing significant health risks. Observational studies have indicated a potential linkage between ARDS and various interleukins, such as Interleukin-8, −2, −6, and −1β ...
Jia-wei Ma, Jia-wei Ma, Ji-chun Tang, Hong-zhi Fang   +3 more
doaj   +1 more source

Expression of interleukin 2 receptors on activated human B cells. [PDF]

, 1984
Using anti-Tac, a monoclonal anti-interleukin 2 (IL-2) receptor antibody, we have explored the possibility that certain activated B cells display receptors for IL-2.
Bongiovanni, KF, Depper, JM, Goldman, CK, Greene, WC, Korsmeyer, SJ, Leonard, WJ, Robb, RJ, Sharrow, SO, Waldmann, TA   +8 more
core  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Interleukin-17A: The Key Cytokine in Neurodegenerative Diseases

Frontiers in Aging Neuroscience, 2020
Neurodegenerative diseases are characterized by the loss of neurons and/or myelin sheath, which deteriorate over time and cause dysfunction. Interleukin 17A is the signature cytokine of a subset of CD4+ helper T cells known as Th17 cells, and the IL-17 ...
Junjue Chen, Xiaohong Liu, Yisheng Zhong
doaj   +1 more source