Results 61 to 70 of about 439,419 (286)

The gut-brain axis, BDNF, NMDA and CNS disorders [PDF]

, 2016
Gastro-intestinal (GI) microbiota and the ‘gut-brain axis’ are proving to be increasingly relevant to early brain development and the emergence of psychiatric disorders.
Maqsood, Raeesah, Stone, Trevor W.
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Critical Evaluation of the Role of Transcription Factor RAR-Orphan Receptor-γt in the Development of Chronic Inflammatory Dermatological Diseases: A Promising Therapeutic Target

Biomolecules
Nuclear receptors (NRs) are transcription factors regulated by ligands that direct metabolism, development, and immunity. The NR superfamily constitutes a principal category of pharmacological targets for human ailments.
Anik Pramanik, Pallabi Mondal, Sankar Bhattacharyya   +2 more
doaj   +1 more source

Analysis of Chemical Composition and Pharmacological Activity of Fengdan Peony Pods [PDF]

Shipin Kexue
The purpose of this study was to explore the bioactive components of Fengdan peony pods and their mechanisms of action by using network pharmacology and molecular docking.
ZHANG Yanping, ZHANG Chenxi, ZUO Haichao, GAO Di, WU Qiqi, SONG Yafei, ZHAO Liyuan
doaj   +1 more source

γδ T cells affect IL-4 production and B-cell tolerance [PDF]

, 2014
γδ T cells can influence specific antibody responses. Here, we report that mice deficient in individual γδ T-cell subsets have altered levels of serum antibodies, including all major subclasses, sometimes regardless of the presence of αβ T cells.
Andrew Getahun, Cohen, Finkelman, Gerber, Greg A. Kirchenbaum, Hidaka, Hirose, Hua Huang, Izui, John C. Cambier, Koichi Ikuta, Kubo, Lawrence J. Wysocki, M. Kemal Aydintug, Rebecca L. O’Brien, Ryan A. Heiser, Simon R. Carding, Sperling, Sunaga, Tamara L. Casper, Thiago O. Detanico, Willi K. Born, Yafei Huang   +22 more
core   +1 more source

Interleukin-17 receptor polymorphism predisposes to primary graft dysfunction after lung transplantation [PDF]

The Journal of Heart and Lung Transplantation, 2015
Primary graft dysfunction (PGD), with an incidence of 11% to 57%, is a major cause of morbidity and mortality within the first 30 days after lung transplantation (LTx). In this study, we postulate that recipient genetic variants in interleukin-17 and -23 receptor genes (IL-17R and IL-23R, respectively) may predispose LTx recipients to an increased risk
Somers, Jana, Ruttens, David, Verleden, Stijn, Vandermeulen, Elly, Piloni, Davide, Wauters, Els, Lambrechts, Diether, Vos, Robin, Verleden, Geert, Vanaudenaerde, Bart, Van Raemdonck, Dirk   +10 more
openaire   +4 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Signalling Pathways Implicated in Obesity Associated Cancers [PDF]

, 2014
Grant support: The Scottish Government's Rural and Environment Science and Analytical Services Division. Declaration of interest: The author declares that there is no conflict of interest.Peer reviewedPublisher ...
Drew, Janice E.
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The Interleukin-17 Induced Activation and Increased Survival of Equine Neutrophils Is Insensitive to Glucocorticoids. [PDF]

PLoS ONE, 2016
BACKGROUND:Glucocorticoids (GCs) are the most effective drugs for the treatment of human asthma. However, a subgroup of asthmatic patients with neutrophilic airway inflammation is insensitive to GCs.
Ruby Yoana Murcia, Amandine Vargas, Jean-Pierre Lavoie   +2 more
doaj   +1 more source