Results 61 to 70 of about 491,128 (209)

Molecular basis of a high affinity murine interleukin-5 receptor. [PDF]

The EMBO Journal, 1991
The mouse interleukin-5 receptor (mIL-5R) consists of two components one of which, the mIL-5R alpha-chain, binds mIL-5 with low affinity. Recently we demonstrated that monoclonal antibodies (Mabs) recognizing the second mIL-5R beta-chain, immunoprecipitate a p130-140 protein doublet which corresponds to the mIL-3R and the mIL-3R-like protein, the ...
R, Devos, G, Plaetinck, J, Van der Heyden, S, Cornelis, J, Vandekerckhove, W, Fiers, J, Tavernier   +6 more
openaire   +2 more sources

Targeting P2X7 receptor for the treatment of central post-stroke pain in a rodent model

Neurobiology of Disease, 2015
Stroke is a leading cause of death and disability in industrialized countries. Approximately 8–14% of stroke survivors suffer from central post-stroke pain (CPSP) when hemorrhagic stroke occurs in lateral thalamic regions, which severely affects their ...
Yung-Hui Kuan, Hsi-Chien Shih, Sung-Chun Tang, Jiann-Shing Jeng, Bai-Chuang Shyu   +4 more
doaj   +1 more source

Endocannabinoid receptor blockade increases hepatocyte growth factor and reduces insulin levels in obese women with polycystic ovary syndrome [PDF]

, 2016
There is evidence from animal and in-vitro studies that activation of the endocannabinoid system (EC) through cannabinoid receptor 1 (CB-1) is associated with liver injury, inflammation and hepatocellular carcinoma.1 Data suggests endogenous cannabinoids
Ahmed, Lina, Atkin, Stephen L., Coady, Anne-Marie, Dakroury, Youssra, Elshewehy, Abeer M. M., Kilpatrick, Eric S., Sathyapalan, Thozhukat   +6 more
core   +2 more sources

Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance [PDF]

, 2012
INTRODUCTION Endosomal toll-like receptors (TLRs) have recently emerged as potential contributors to the inflammation observed in human and rodent models of rheumatoid arthritis (RA).
Alzabin, Saba, Kong, Philip, Medghalchi, Mino, Palfreeman, Andrew, Sacre, Sandra, Williams, Richard   +5 more
core   +1 more source

A Case of Secondary Hemophagocytic Lymphohistiocytosis in a Patient With Acute HIV Infection

Annals of Internal Medicine: Clinical Cases
A 22-year-old man who has sex with men with no significant medical history presented with a 2-week history of fever and right upper abdominal pain. Initial blood tests revealed leukopenia, thrombocytopenia, and elevated liver enzymes.
Yiliam Castillo, Liorge Dominguez, Antonio Crespo, Julio J. Alvarez Cardona   +3 more
doaj   +1 more source

Biological Properties and the Role of IL-25 in Disease Pathogenesis

Journal of Immunology Research, 2018
The interleukin- (IL-) 17 superfamily, a T cell-derived cytokine, consists of 6 ligands (IL-17A–IL-17F) and 5 receptors (IL-17RA–IL-17RE). IL-17A, a prototype member of this family, is involved in the pathogenesis of allergies, autoimmune diseases ...
Yuwan Liu, Zewei Shao, Guoqiang Shangguan, Qingli Bie, Bin Zhang   +4 more
doaj   +1 more source

IL-17A contributes to perioperative neurocognitive disorders through blood-brain barrier disruption in aged mice

Journal of Neuroinflammation, 2018
Background Perioperative neurocognitive disorders (PND) occur frequently after surgery, especially in aged patients. Surgery-induced neuroinflammation and blood-brain barrier (BBB) dysfunction play a crucial role in the pathogenesis of PND.
Pengfei Ni, Hongquan Dong, Yiwei Wang, Qin Zhou, Mengmeng Xu, Yanning Qian, Jie Sun   +6 more
doaj   +1 more source

Mechanisms altering airway smooth muscle cell Ca(2+) homeostasis in two asthma models [PDF]

, 2008
Background: Asthma is characterized by airway remodeling, altered mucus production and airway smooth muscle cell (ASMC) contraction causing extensive airway narrowing. In particular, alterations of ASMC contractility seem to be of crucial importance. The
Bergner, Albrecht, Edelmann, Martin, Fischer, Rainald, Huber, Rudolf M., Kellner, Julia, Oelmez, Hamza, Tantzscher, Juliane   +6 more
core   +1 more source

Molecular cloning and expression of the human interleukin 5 receptor. [PDF]

The Journal of experimental medicine, 1992
Human interleukin 5 (IL-5) plays an important role in proliferation and differentiation of human eosinophils. We report the isolation of cDNA clones from cDNA libraries of human eosinophils by using murine IL-5 receptor alpha chain cDNA as a probe. Analysis of the predicted amino acid sequence indicated that the human IL-5 receptor has approximately 70%
Y, Murata, S, Takaki, M, Migita, Y, Kikuchi, A, Tominaga, K, Takatsu   +5 more
openaire   +2 more sources

Cisplatin induces hippocampal neurotoxicity and cognitive impairment in rats through neuroinflammation, oxidative stress, and overexpression of glutamatergic receptors mRNA

Frontiers in Pharmacology
Chemotherapy-induced cognitive deficits are a prevalent adverse effect in patients with cancer undergoing chemotherapy. We investigated cisplatin-induced neurotoxicity by assessing neuroinflammation and expression of glutamate receptors.
Ahmad Hamad Alhowail
doaj   +1 more source