Results 121 to 130 of about 644,252 (236)

An expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing

Nature Communications, 2018
Little is known about the role of variant ionotropic glutamate receptors (IRs) in insect taste. Here the authors characterise the expression pattern of IRs in the Drosophila gustatory system and highlight the role of one receptor, IR56d, in the detection
Juan Antonio Sánchez-Alcañiz, Ana Florencia Silbering, Vincent Croset, Giovanna Zappia, Anantha Krishna Sivasubramaniam, Liliane Abuin, Saumya Yashmohini Sahai, Daniel Münch, Kathrin Steck, Thomas O. Auer, Steeve Cruchet, G. Larisa Neagu-Maier, Simon G. Sprecher, Carlos Ribeiro, Nilay Yapici, Richard Benton   +15 more
doaj   +1 more source

Cancer Neuroscience: From Local Neuro–Immune Microenvironments to Systemic Brain–Body Circuitry

MedComm, Volume 7, Issue 9, September 2026.
This review outlines the cancer neuroscience paradigm, spanning systemic brain–body circuitry and local neuro–immune–tumor microenvironments. We discuss how tumors promote axonogenesis and pseudo‐synapse formation, and how sensory neuropeptides, such as CGRP, contribute to CD8+ T‐cell exhaustion.
Mingxuan Xie, Yu Zhao, Xinruo Xing, Yuqiang Liu, Jungang Zhao, Maojin Yao, Jun Tang, Jianzhu Zhao   +7 more
wiley   +1 more source

Evolution of the delta family of ionotropic glutamate receptors [PDF]

I pattedyrhjernen er ionotrope glutamatreseptorer (iGluR) avgjørende for å formidle eksitatorisk nevrotransmisjon. Disse reseptorene deles inn i fire forskjellige familier: AMPA, KA, NMDA og delta. I motsetning til de andre iGluR-familiene aktiveres ikke
Rosano, Giulio
core  

Cholecystokinin Induces Ca2+ Transients in Brainstem Neurons, Astrocytes and Central Vagal Terminals in Jugular/Nodose Ganglia–Brainstem Slice Cultures

European Journal of Neuroscience, Volume 64, Issue 5, September 2026.
A jugular/nodose ganglion–brainstem slice culture with intact ganglia attached to the brainstem, preserving functional vagal afferent pathways to the brainstem. In this preparation, cholecystokinin activates brainstem neurons, central vagal terminals and brainstem astrocytes, establishing this preparation as a powerful model for dissecting the neuro ...
Adam Ujhelyi, Rana Soylu Kucharz, Jens Christian Rekling   +2 more
wiley   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, Volume 293, Issue 18, Page 5481-5513, September 2026.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Synaptobrevin‐2 Containing Extracellular Vesicles Are Rapidly Incorporated Into Mammalian Neurons via a Dynamin‐Dependent Pathway

Journal of Neurochemistry, Volume 170, Issue 9, September 2026.
In this article, Hannett and colleagues investigate extracellular vesicles (EVs) secreted by neurons, small membrane‐bound organelles that transmit information among cells. They found that EVs are mainly uptaken by target neurons via a mechanism dependent on the membrane scission protein Dynamin.
Victoria Hannett, A. Alejandro Vilcaes, Siewert Hugelier, Qing Tang, Melike Lakadamyali, Natali L. Chanaday   +5 more
wiley   +1 more source

Oestrogen modulates stress‐induced vagally‐dependent gastric responses to oxytocin

The Journal of Physiology, Volume 604, Issue 18, Page 7570-7593, 15 September 2026.
Abstract figure legend In female rats, PVNCRF‐DMV neurons and DMV CRF1 receptors are tonically active, allowing oxytocin (OXT) to modulate inhibitory GABAergic transmission to DMV neurons. Parasympathetic control of gastric functions involves engagement of non‐adrenergic non‐cholinergic vagal efferent pathways, but recruitment of distinct pathways ...
Ruchi Bhagat, R. Alberto Travagli, Kirsteen N. Browning   +2 more
wiley   +1 more source

The electrophysiology of ionotropic glutamate receptors expressed in human cell lines, HEK293 and TE671 [PDF]

Ionotropic glutamate receptors consist of NMDA, AMPA and kainate receptors and are responsible for the conduction of synaptic transmission, long term potentiation, and synaptic plasticity and are implicated in a wide range of neurological diseases. Human
Newman, Amy
core   +2 more sources

Allosteric modulators of metabotropic glutamate receptors: from virtual screening to experimental validation [PDF]

, 2007
The goal of this thesis was to gain further insight into the binding behavior of ligands in the heptahelical domain (HD) of group I metabotropic glutamate receptors (mGluRs).
Noeske, Tobias
core  

Ionotropic glutamate receptors in GtoPdb v.2025.4 [PDF]

The ionotropic glutamate receptors comprise members of the NMDA (N-methyl-D-aspartate), AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid) and kainate receptor classes, named originally according to their preferred, synthetic, agonist ...
Watkins, Jeffrey C., Olsen, Richard, Mishina, Masayoshi, Peineau, Stephane, Lerma, Juan, Heinemann, Stephen F., Mulle, Christophe, Lodge, David, Peters, John A., Nakanishi, Shigetada, Spedding, Michael, Hollmann, Michael, Collingridge, Graham L., Dingledine, Ray, Seeburg, Peter, Bettler, Bernhard, Mayer, Mark   +16 more
core   +1 more source