Results 171 to 180 of about 17,556 (218)

LEUKOTRIENE B4/LEUKOTRIENE B4 RECEPTOR PATHWAY IS INVOLVED IN HEPATIC MICROCIRCULATORY DYSFUNCTION ELICITED BY ENDOTOXIN

Shock, 2008
Leukotrienes (LTs), metabolites of arachidonic acid through 5-lipoxygenase (5-LOX), have been known to play a role in leukocyte recruitment. However, the contribution of LTB4 to liver microcirculatory dysfunction during endotoxemia remains unknown. LTB4 receptor (BLT1) has been identified as a high-affinity receptor specific for LTB4. The present study
Sohei, Ito, Yoshiya, Ito, Hiroyuki, Katagiri, Tatsunori, Suzuki, Sumio, Hoka, Takehiko, Yokomizo, Takao, Shimizu, Masataka, Majima   +7 more
openaire   +2 more sources

Detergent solubilization of human neutrophil leukotriene B4 receptors

Biochemical and Biophysical Research Communications, 1985
Specific leukotriene B4 (LTB4) receptors in human neutrophils were solubilized by treatment of "receptor fraction" membranes with the zwitterionic detergent (3-[(3-cholamidopropyl)-dimethylammonio]1-propane sulfonate (CHAPS). The soluble receptors were assayed by polyethylene glycol (PEG) precipitation coupled with Millipore filtration. The solubilized
A H, Lin, P L, Ruppel, R R, Gorman
openaire   +2 more sources

Leukotriene B4 receptors as therapeutic targets for ophthalmic diseases

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2020
Leukotriene B4 (LTB4) is an inflammatory lipid mediator produced from arachidonic acid by multiple reactions catalyzed by two enzymes 5-lipoxygenase (5-LOX) and LTA4 hydrolase (LTA4H). The two receptors for LTB4 have been identified: a high-affinity receptor, BLT1, and a low-affinity receptor, BLT2.
Toshiaki, Hirakata, Akira, Matsuda, Takehiko, Yokomizo   +2 more
openaire   +2 more sources

Hepatocyte leukotriene B4 receptor 1 promotes NAFLD development in obesity

Hepatology, 2022
Background and Aims: NAFLD is the most prevalent chronic liver disease worldwide and has emerged as a serious public health issue with no approved treatment. The development of NAFLD is strongly associated with hepatic lipid content, and patients with NAFLD have significantly higher rates of hepatic de novo lipogenesis (DNL ...
Xingfeng Liu, Kai Wang, Luhai Wang, Lijuan Kong, Shaocong Hou, Yanjun Wan, Chunxiao Ma, Jingwen Chen, Xiaowei Xing, Caiyi Xing, Qian Jiang, Qijin Zhao, Bing Cui, Zhifeng Huang, Pingping Li   +14 more
openaire   +2 more sources

Effect of a leukotriene B4 receptor antagonist on leukotriene B4-induced neutrophil chemotaxis in cavine dermis

Inflammation, 1989
Leukotriene B4 (LTB4) is a proinflammatory product of arachidonic acid metabolism that has been implicated as a mediator in a number of inflammatory diseases. When injected intradermally into the cavine. LTB4 elicits a dose-dependent immigration (chemotaxis) of neutrophils (PMNs) into the injection sites as assessed by the presence of a neutrophil ...
D J, Fretland, D L, Widomski, J M, Zemaitis, S W, Djurić, R L, Shone   +4 more
openaire   +2 more sources

BLT2, a Second Leukotriene B4 Receptor

2001
Leukotriene B4 (LTB4) is a potent chemoattractant and activator for granulocytes and macrophages [1–3]. The high-affinity receptor for LTB4 (BLT1) was cloned and shown to be a G-protein-coupled receptor (GPCR) with low structural homology to the other known GPCRs [4]. Here we report a second LTB4 receptor, BLT2, found in a gene cluster with BLT1 [5,6].
Takehiko Yokomizo, Kazuhiko Kato, Kan Terawaki, Takashi Izumi, Takao Shimizu   +4 more
openaire   +1 more source

Functional properties of guinea pig eosinophil leukotriene B4 receptor

The Journal of Immunology, 1991
Abstract It is currently thought that pulmonary eosinophils play a proinflammatory role in bronchial asthma. Leukotriene B4 (LTB4) is being considered as an important mediator in regulating eosinophil function because of its potent activities in inducing leukocyte chemotaxis, chemokinesis, degranulation, and aggregation. Because the LTB4
C F, Ng, F F, Sun, B M, Taylor, M S, Wolin, P Y, Wong   +4 more
openaire   +2 more sources

Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist

European Journal of Pharmacology, 1992
The actions of LY255283, a leukotriene (LT) B4 receptor antagonist, were examined on guinea pig lung. LTB4 and LY255283 displaced [3H]LTB4 from its binding site on lung membranes with pKi values of 9.9 and 7.0, respectively. In the functional correlate of the binding studies, LY255283 competitively reduced contractile responses of lung parenchyma to ...
S A, Silbaugh, P W, Stengel, S L, Cockerham, C R, Roman, D L, Saussy, S M, Spaethe, T, Goodson, D K, Herron, J H, Fleisch   +8 more
openaire   +2 more sources

Molecular Cloning and Characterization of Leukotriene B4 Receptor

1999
Leukotriene B4 (LTB4) is a potent proinflammatory and chemotactic factor biosynthesized in various tissues, which is involved in inflammation, immune responses and host defense against infection.1 LTB4 activates inflammatory cells by binding to its cell-surface receptor (BLT).
T, Izumi, T, Yokomizo, T, Igarashi, T, Shimizu   +3 more
openaire   +2 more sources

Distribution of leukotriene B4 receptors in human hematopoietic cells

Immunopharmacology, 2000
Leukotriene B4 (LTB4), a product of arachidonic acid metabolism, plays an important role in inflammatory responses. We have cloned from human erythroleukemia cells, a G protein-coupled receptor, designated P2Y(7), which was later identified as the receptor for LTB4 (B-LTR).
V R, Dasari, J, Jin, S P, Kunapuli
openaire   +2 more sources