Results 181 to 190 of about 17,556 (218)
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Leukotriene B4 receptors: Novel roles in immunological regulations
Advances in Enzyme Regulation, 2011Mammals have at least two receptors for LTB4; high-affinity BLT1 and low-affinity BLT2, both of which are GPCRs. 12-HHT serves as a more potent and abundant ligand for BLT2 than LTB4. BLT1 is expressed in a variety of inflammatory and immune cells including granulocytes, eosinophils, macrophages, differentiated Th1, Th2 and Th17 cells, effecter CD8+ T ...
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Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones
Journal of Medicinal Chemistry, 1992A series of hydroxyacetophenones was prepared for evaluation as leukotriene B4 (LTB4) receptor antagonists, culminating in 1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5- yl)heptyl]oxy]phenyl]ethanone (compound 35, LY255283). Using an assay for inhibition of specific [3H]LTB4 binding to human PMN, we found that substitution of a nonpolar ...
D K, Herron +8 more
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American Journal of Respiratory and Critical Care Medicine, 2000
Leukotriene B 4 (LTB 4 ) is a potent chemotactic compound that is synthesized from arachidonic acid, by the action of 5-lipoxygenase and leukotriene A 4 hydrolase (1-3). While 5-lipoxygenase is present to a limited extent in leukocytes (4), LTA 4 hydrolase is present ubiquitously in many tissues including the lung, kidney, spleen, and ...
T, Yokomizo +5 more
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Leukotriene B 4 (LTB 4 ) is a potent chemotactic compound that is synthesized from arachidonic acid, by the action of 5-lipoxygenase and leukotriene A 4 hydrolase (1-3). While 5-lipoxygenase is present to a limited extent in leukocytes (4), LTA 4 hydrolase is present ubiquitously in many tissues including the lung, kidney, spleen, and ...
T, Yokomizo +5 more
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Up-Regulated Membrane and Nuclear Leukotriene B4 Receptors in COPD
Chest, 2006We investigated the role of two leukotriene B4 (LTB4) receptors, BLT1 and peroxisome proliferator-activated receptor (PPAR)-alpha, in conferring the susceptibility to develop COPD in smokers. Proinflammatory LTB4 activities are mediated by BLT1, while the inactivation of LTB4 is promoted by PPARalpha.BLT1 and PPARalpha proteins were quantified by ...
MARIAN E +6 more
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Leukotriene B4 receptors on guinea pig alveolar eosinophils.
The Journal of Pharmacology and Experimental Therapeutics, 1991The existence of receptors for LTB4 on highly purified guinea pig alveolar eosinophils was investigated. Massive infiltration of eosinophils in alveolar spaces was induced in guinea pigs by i.v. injections of Sephadex beads G50 (16 mg/kg). Alveolar eosinophils (50 x 10(6) cells) were purified to approximately 98% by Percoll continuous density gradient ...
K, Maghni +5 more
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Essential fatty acids are antagonists of the leukotriene B4 receptor
Prostaglandins, Leukotrienes and Essential Fatty Acids, 1995A series of essential fatty acids and fatty acid derivatives were evaluated for their ability to inhibit [3H] leukotriene B4 (LTB4) binding to pig neutrophil membranes. The fatty acids varied in chain length, extent of unsaturation, position of unsaturation, and isomerization.
K A, Yagaloff +3 more
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Protein kinase C blockers and neutrophil receptors for leukotriene B4
Biochemical and Biophysical Research Communications, 1989Three protein kinase C blockers (staurosporin, Cl, and sphinganine) acted temperature- and time-dependently on human neutrophils to lower the affinity and number of high affinity plasmalemma receptors available to leukotriene B4. The drugs did not alter the ligand's binding to isolated plasma membranes or reduce intact cell binding of platelet ...
J T, O'Flaherty, D, Jacobson
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Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment
Nature Immunology, 2003Leukotriene B4 (LTB4) was originally described as a potent lipid myeloid cell chemoattractant, rapidly generated from innate immune cells, that activates leukocytes through the G protein-coupled receptor BLT1. We report here that BLT1 is expressed on effector CD4+ T cells generated in vitro as well as in vivo when effector T cells migrate out of the ...
Andrew M, Tager +8 more
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1987
Leukotriene B4 (LTB4) is a product of arachidonic acid metabolism derived through the action of the 5-lipoxygenase pathway. The end product of the 5-lipoxygenase reaction, LTA4, is converted by a specific enzyme, leukotriene A4 hydrolase, to LTB4 (5[S],12[R]-dihydroxy 6,14-cis-8,10-trans eicosatetraenoic acid).
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Leukotriene B4 (LTB4) is a product of arachidonic acid metabolism derived through the action of the 5-lipoxygenase pathway. The end product of the 5-lipoxygenase reaction, LTA4, is converted by a specific enzyme, leukotriene A4 hydrolase, to LTB4 (5[S],12[R]-dihydroxy 6,14-cis-8,10-trans eicosatetraenoic acid).
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Evidence for leukotriene B4 receptors in human neutrophils.
Advances in prostaglandin, thromboxane, and leukotriene research, 1986[3H]LTB4 binds concentration-dependently to intact human PMNs. The binding is saturable, reaches equilibrium in 10 min at 4 degrees C, and is readily reversible. Mathematical modeling analysis reveals biphasic binding of [3H]LTB4, indicating two discrete populations of binding sites.
R R, Gorman, P L, Ruppel, A H, Lin
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