Results 91 to 100 of about 24,569 (232)
Specific Involvement of G Proteins in Regulation of Serum Response Factor-mediated Gene Transcription by Different Receptors [PDF]
, 1998 Regulation of serum response factor (SRF)-mediated gene transcription by G protein subunits and G protein-coupled receptors was investigated in transfected NIH3T3 cells and in a cell line that was derived from mice lacking G_(αq) and G_(α11).
Mao, Junhao +4 more
core +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Microalgae are increasingly recognised as powerful platforms for the sustainable production of lipids and terpenoids, with expanding applications in the food, fuel and biomanufacturing industries. In this updated review, we consolidate and critically assess the most recent advances in synthetic biology and metabolic engineering of key ...
Ty Shitanaka +6 more
wiley +1 more source
Primary human endothelial cells secrete agents that reduce responsiveness to lysophosphatidic acid (LPA) [PDF]
, 2012 The plasma level of LPA (lysophosphatidic acid) (200–600 nM) is well within the range that promotes proliferation and migration of vascular ECs (endothelial cells), yet vessels are quiescent and stable.
Kazlauskas, Andrius, Park, Eun Young
core +3 more sources
Lysophosphatidic Acid Receptor LPAR6 Supports the Tumorigenicity of Hepatocellular Carcinoma [PDF]
Cancer Research, 2015 Abstract The aberrant processes driving hepatocellular carcinoma (HCC) are not fully understood. Lysophosphatidic acid receptors (LPAR) are commonly overexpressed in HCC, but their contributions to malignant development are not well established.
MAZZOCCA, ANTONIO +11 more
openaire +4 more sources
Optimization of photobiomodulation therapy for spinal cord injury: A review
Photochemistry and Photobiology, EarlyView.Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew +3 more
wiley +1 more source
LPA receptor signaling: pharmacology, physiology, and pathophysiology
Journal of Lipid Research, 2014 Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and nonvertebrate organisms that mediates diverse biological actions and demonstrates medicinal relevance. LPA's functional roles are driven by extracellular signaling through at
Yun C. Yung +2 more
doaj +1 more source
Journal of Neuroinflammation, 2021 Background Lysophosphatidic acid receptors (LPARs) are G-protein-coupled receptors involved in many physiological functions in the central nervous system. However, the role of the LPARs in multiple sclerosis (MS) has not been clearly defined yet. Methods
Jong Hee Choi +6 more
doaj +1 more source
Deficiency of autotaxin/lysophospholipase D results in head cavity formation in mouse embryos through the LPA receptor-Rho-ROCK pathway [PDF]
, 2010 Autotaxin, encoded by the Enpp2 gene, generates lysophosphatidic acid (LPA) extracellularly, eliciting various cellular responses through specific LPA receptors.
Keino-Masu Kazuko +4 more
core +1 more source
Internalization of Exogenous Myelin by Oligodendroglia Promotes Lineage Progression
Glia, Volume 74, Issue 3, March 2026.Oligodendroglia internalize extracellular myelin debris in vitro and in vivo. Internalized myelin modulates lipid metabolism and lipid droplet formation. Myelin‐derived signals promote oligodendroglial proliferation and lineage progression. ABSTRACT Oligodendrocytes, traditionally recognized for their role in central nervous system myelination, have ...
Carla Peiró‐Moreno +7 more
wiley +1 more source
ER localized bestrophin1 activates Ca2+ dependent ion channels TMEM16A and SK4 [PDF]
, 2009 Bestrophins form Ca2+ activated Cl- channels and regulate intercellular Ca2+ signaling1. We demonstrate that bestrophin 1 is localized in the endoplasmic reticulum (ER), where it physically interacts with stromal interacting molecule 1 (Stim1), the ER ...
Fadi AlDehni +6 more
core +2 more sources