Results 121 to 130 of about 24,569 (232)

Tks4‐Targeted Gene Therapy Inhibited White Adipocyte Hypertrophy in Mice

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Tks4 knockout or knockdown by AAV mediated shRNA both successfully restricted adipocyte hypertrophy in high fat diet. The reduction of TAG was validated by biochemistry and lipidomics analyses. This study suggested a potential of Tks4 targeted therapy in obesity intervention. ABSTRACT Obesity is one of the most prevalent public health issues worldwide,
Meng Tian, Jingwen Deng, Yuzhu Hong, Ruitong Liu, Shengnan Li, Xiaoxiao He   +5 more
wiley   +1 more source

Metabolites involved in cellular communication among human cumulus-oocyte-complex and sperm during in vitro fertilization [PDF]

, 2015
Background: Fertilization is a key physiological process for the preservation of the species. Consequently, different mechanisms affecting the sperm and the oocyte have been developed to ensure a successful fertilization. Thus, sperm acrosome reaction is
Avilés Sánchez, Manuel, Bernabeu, Rafael, García Hernández, Eva María, Gil-Izquierdo, Ángel, González-Brusi, Leopoldo, Guerrero, Jaime, Gómez-Torres, María José, Izquierdo-Rico, María José, Medina, Sonia, Orduna, Jesús, Savirón, María, Ten Morro, Jorge   +11 more
core   +2 more sources

Lysophosphatidic acid receptor 1 inhibition: a potential treatment target for pulmonary fibrosis [PDF]

European Respiratory Review
Lysophosphatidic acid (LPA)-mediated activation of LPA receptor 1 (LPAR1) contributes to the pathophysiology of fibrotic diseases such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis (SSc). These diseases are associated with high morbidity and mortality despite current treatment options.
Volkmann, Elizabeth, Denton, Christopher, Kolb, Martin, Wijsenbeek-Lourens, Marlies, Emson, Claire, Hudson, Krischan, Amatucci, Anthony, Distler, Oliver, Allanore, Yannick, Khanna, Dinesh, Allanore, Yannick   +10 more
openaire   +8 more sources

G protein-coupled receptors at the crossroad between physiologic and pathologic angiogenesis : old paradigms and emerging concepts [PDF]

, 2017
G protein-coupled receptors (GPCRs) have been implicated in transmitting signals across the extra- and intra-cellular compartments, thus allowing environmental stimuli to elicit critical biological responses.
Azuma, Ernestina De Francesco, Federica Sotgia, Ferrara, Haralabopoulos, Kryczek, Marcello Maggiolini, Michael Lisanti, Montaner, Rigiracciolo, Robert Clarke, Sax, Semenza, Sodhi, Spiegel, Strange, Zalewska   +16 more
core   +2 more sources

Lysophosphatidic Acid (LPA) Signaling in Human and Ruminant Reproductive Tract

Mediators of Inflammation, 2014
Lysophosphatidic acid (LPA) through activating its G protein-coupled receptors (LPAR 1–6) exerts diverse cellular effects that in turn influence several physiological processes including reproductive function of the female.
Izabela Wocławek-Potocka, Paulina Rawińska, Ilona Kowalczyk-Zieba, Dorota Boruszewska, Emilia Sinderewicz, Tomasz Waśniewski, Dariusz Jan Skarzynski   +6 more
doaj   +1 more source

Co-stimulation of LPAR1 and S1PR1/3 increases the transplantation efficacy of human mesenchymal stem cells in drug-induced and alcoholic liver diseases

Stem Cell Research & Therapy, 2018
Background One of the major obstacles facing stem cell therapy is the limited number of functional stem cells available after transplantation due to the harsh microenvironment surrounding the damaged tissue.
Mianhuan Li, Yi Lv, Feng Chen, Xiaoyan Wang, Jiang Zhu, Hao Li, Jia Xiao   +6 more
doaj   +1 more source

Calcium puffs are generic InsP₃-activated elementary calcium signals and are downregulated by prolonged hormonal stimulation to inhibit cellular calcium responses [PDF]

, 2001
Elementary Ca2+ signals, such as "Ca2+ puffs", which arise from the activation of inositol 1,4,5-trisphosphate receptors, are building blocks for local and global Ca2+ signalling.
Berridge, Michael J., Bootman, Martin D., De Smedt, Humbert, de Smet, Patrick, Holmes, Andrew, Lipp, Peter, Missiaen, Ludwig, Parys, Jan B., Thomas, David, Thuring, Jan, Tovey, Stephen C., Young, Kenneth W.   +11 more
core  

Lysophosphatidic Acid Receptor 3 (LPA3): Signaling and Phosphorylation Sites

International Journal of Molecular Sciences
LPA3 receptors were expressed in TREx HEK 293 cells, and their signaling and phosphorylation were studied. The agonist, lysophosphatidic acid (LPA), increased intracellular calcium and ERK phosphorylation through pertussis toxin-insensitive processes. Phorbol myristate acetate, but not LPA, desensitizes LPA3-mediated calcium signaling. The agonists and
K. Helivier Solís, M. Teresa Romero-Ávila, Ruth Rincón-Heredia, J. Adolfo García-Sáinz   +3 more
openaire   +2 more sources

Intranuclear Signaling Cascades Triggered by Nuclear GPCRs

, 2016
G protein-couped receptors (GPCRs) play a key role on cellular membranes, where they respond to a broad array of extracellular signals such as lipids, peptides, proteins and sensory agents.
AMMENDOLA, ROSARIO, CATTANEO, FABIO, ESPOSITO, GABRIELLA, Fioretti, Tiziana, PARISI, MELANIA   +4 more
core   +1 more source

Lysophospholipid receptors in neurodegeneration and neuroprotection

Exploration of Neuroprotective Therapy
The central nervous system (CNS) is one of the most complex physiological systems, and treatment of CNS disorders represents an area of major medical need.
Eric Birgbauer
doaj   +1 more source