The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life.
PLoS ONE, 2015 Autotaxin (ATX, Enpp2) is a secreted lysophospholipase D catalysing the production of lysophosphatidic acid, a pleiotropic growth factor-like lysophospholipid.
Aggeliki Katsifa +6 more
doaj +1 more source
Canoe full of hot paddlers: TRPV1 neurons steering cardiorespiratory control
The Journal of Physiology, EarlyView.
Richard J. A. Wilson +1 more
wiley +1 more source
Lysophosphatidic Acid (LPA) Signaling in Human and Ruminant Reproductive Tract
Mediators of Inflammation, 2014 Lysophosphatidic acid (LPA) through activating its G protein-coupled receptors (LPAR 1–6) exerts diverse cellular effects that in turn influence several physiological processes including reproductive function of the female.
Izabela Wocławek-Potocka +6 more
doaj +1 more source
LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor.
PLoS ONE, 2011 Lysophosphatidic acid (LPA), a lipid mediator enriched in serum, stimulates cell migration, proliferation and other functions in many cell types. LPA acts on six known G protein-coupled receptors, termed LPA(1-6), showing both overlapping and distinct ...
Maikel Jongsma +4 more
doaj +1 more source
Lysophosphatidic Acid Receptor 3 (LPA3): Signaling and Phosphorylation Sites
International Journal of Molecular SciencesLPA3 receptors were expressed in TREx HEK 293 cells, and their signaling and phosphorylation were studied. The agonist, lysophosphatidic acid (LPA), increased intracellular calcium and ERK phosphorylation through pertussis toxin-insensitive processes. Phorbol myristate acetate, but not LPA, desensitizes LPA3-mediated calcium signaling. The agonists and
K. Helivier Solís +3 more
openaire +2 more sources
Lysophospholipid receptors in neurodegeneration and neuroprotection
Exploration of Neuroprotective TherapyThe central nervous system (CNS) is one of the most complex physiological systems, and treatment of CNS disorders represents an area of major medical need.
Eric Birgbauer
doaj +1 more source
International Journal of Inflammation, 2011 Lysophosphatidic acid (LPA) is a lipid mediator which binds to G-protein-coupled receptors and regulates various cellular responses, including inflammation of endothelial cells.
Chih-Hsin Lin, JenHer Lu, Hsinyu Lee
doaj +1 more source
Roles of lipid mediators in early pregnancy events
Reproductive Medicine and BiologyBackground Early pregnancy events, including embryo implantation, are critical for maintaining a healthy pregnancy and facilitating childbirth. Despite numerous signaling pathways implicated in establishing early pregnancy, a comprehensive understanding ...
Shizu Aikawa, Yasushi Hirota
doaj +1 more source
A Targeted Therapeutic Rescues Botulinum Toxin-A Poisoned Neurons [PDF]
, 2008 Botulinum neurotoxin (BoNT), a Category A biothreat agent, is the most potent poison known to mankind. Currently no antidote is available to rescue poisoned synapses.
Bal Ram Singh +6 more
core +1 more source
Calcium puffs are generic InsP3-activated elementary calcium signals and are downregulated by prolonged hormonal stimulation to inhibit cellular calcium responses [PDF]
, 2001 Elementary Ca2+ signals, such as "Ca2+ puffs", which arise from the activation of inositol 1,4,5-trisphosphate receptors, are building blocks for local and global Ca2+ signalling.
Berridge, Michael J. +11 more
core