2-Carba-lysophosphatidic acid is a novel β-lysophosphatidic acid analogue with high potential for lysophosphatidic acid receptor activation and autotaxin inhibition [PDF]
Scientific Reports, 2021 Cyclic phosphatidic acid (cPA) is a naturally occurring phospholipid mediator that, along with its chemically stabilized analogue 2-carba-cyclic phosphatidic acid (2ccPA), induces various biological activities in vitro and in vivo.
Keiko Fukasawa +10 more
doaj +3 more sources
In Vitro Modeling of Age‐Associated Lipid Mediator's Impact on Vascular Biology Following Platelet Concentrate Transfusion [PDF]
Aging Cell, Volume 25, Issue 4, April 2026.Age‐associated LPA affects adverse reactions and alters platelet and endothelial biology following platelet concentrate transfusion. Age‐associated LPC, S1P could be involved in adverse reactions, in platelet and endothelium biology following a PC transfusion.
Amelie Prier +10 more
wiley +2 more sources
Activation of fibroblast-like synoviocytes derived from rheumatoid arthritis via lysophosphatidic acid-lysophosphatidic acid receptor 1 cascade [PDF]
Arthritis Research & Therapy, 2014 INTRODUCTION: Lysophosphatidic acid (LPA) is a bioactive lipid that binds to G protein–coupled receptors (LPA(1–6)). Recently, we reported that abrogation of LPA receptor 1 (LPA(1)) ameliorated murine collagen-induced arthritis, probably via inhibition ...
Chie Miyabe +9 more
core +4 more sources
Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment. [PDF]
, 2013 Lysophosphatidic acid (LPA) is a pleiotropic phospholipid present in the blood and certain tissues at high concentrations; its diverse effects are mediated through differential, tissue specific expression of LPA receptors.
Cardinal, Sofie +9 more
core +9 more sources
BMC Gastroenterology, 2023 Background This study aims to identify the impact on the reaction while the clasp and sling fibers of the human lower esophageal sphincter are under the electrical field stimulation, by adding lysophosphatidic acid receptor subtypes antagonist.
Yong Feng +3 more
doaj +1 more source
Recent advances on the role of G-protein-coupled receptors in kidney diseases
生物医学转化, 2022 The G-protein-coupled receptors (GPCRs) are widely expressed in many cell types and participate in various cellular biological processes. Several studies have shown that GPCRs-mediated signaling pathways play significant roles in maintaining renal ...
Wang Xiaojie +5 more
doaj +1 more source
Phosphorylation and Internalization of Lysophosphatidic Acid Receptors LPA1, LPA2, and LPA3. [PDF]
PLoS ONE, 2015 The lysophosphatidic acid receptors LPA1, LPA2, and LPA3 were individually expressed in C9 cells and their signaling and regulation were studied. Agonist-activation increases intracellular calcium concentration in a concentration-dependent fashion ...
Rocío Alcántara-Hernández +4 more
doaj +1 more source
Lysophosphatidic Acid Signaling in Cancer Cells: What Makes LPA So Special?
Cells, 2021 Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for G protein-coupled receptors. While LPA exerts effects throughout the body in normal physiological circumstances, its pathological role in cancer is of great ...
Pravita Balijepalli +2 more
doaj +1 more source
In silico analysis of missense mutations in LPAR6 reveals abnormal phospholipid signaling pathway leading to hypotrichosis. [PDF]
PLoS ONE, 2014 Autosomal recessive hypotrichosis is a rare genetic irreversible hair loss disorder characterized by sparse scalp hair, sparse to absent eyebrows and eyelashes, and sparse axillary and body hair.
Syed Irfan Raza +6 more
doaj +1 more source
LPAR1 (lysophosphatidic acid receptor 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on LPAR1 (lysophosphatidic acid receptor 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Murph, MM, Radhakrishna, H
openaire +2 more sources