Role of G{alpha}12 and G{alpha}13 as Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor [PDF]
, 2007 G{alpha}12 and G{alpha}13 function as molecular regulators responding to extracellular stimuli. NF-E2-related factor 2 (Nrf2) is involved in a protective adaptive response to oxidative stress.
Cho, Min Kyung +6 more
core +2 more sources
Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies
Signal Transduction and Targeted Therapy, 2021 Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions both in development and in pathological conditions. Here, we review the literature about the differential signaling of LPA through its specific receptors, which ...
Luiz Henrique Medeiros Geraldo +8 more
doaj +1 more source
LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells [PDF]
, 2017 Melanoma cells steer out of tumours using self-generated lysophosphatidic acid (LPA) gradients. The cells break down LPA, which is present at high levels around the tumours, creating a dynamic gradient that is low in the tumour and high outside.
Insall, Robert H. +10 more
core +1 more source
Ginseng Gintonin Contains Ligands for GPR40 and GPR55
Molecules, 2020 Gintonin, a novel ginseng-derived glycolipoprotein complex, has an exogenous ligand for lysophosphatidic acid (LPA) receptors. However, recent lipid analysis of gintonin has shown that gintonin also contains other bioactive lipids besides LPAs, including
Yeon-Jin Cho +9 more
doaj +1 more source
Lateral access mechanism of LPA receptor probed by molecular dynamics simulation.
PLoS ONE, 2022 G-protein-coupled receptors (GPCR) are a family of membrane receptors that play important roles in the regulation of various physiological phenomena. LPA receptors (LPA1-6) are members of the class A GPCRs, which transduce a lysophosphatidic acid (LPA ...
Rieko Suenaga +4 more
doaj +1 more source
Endogenous lysophosphatidic acid (LPA1) receptor agonists demonstrate ligand bias between calcium and ERK signalling pathways in human lung fibroblasts [PDF]
, 2016 Background and Purpose Human lung fibroblasts (HLF) express high levels of the LPA1 receptor, a GPCR that responds to the endogenous lipid mediator, lysophosphatidic acid (LPA).
Dowling, Mark R, +2 more
core +2 more sources
Lysophosphatidic acid enhances survival of human CD34(+) cells in ischemic conditions [PDF]
, 2015 Several clinical trials are exploring therapeutic effect of human CD34(+) cells in ischemic diseases, including myocardial infarction. Unfortunately, most of the cells die few days after delivery.
Aday, S +11 more
core +1 more source
Advances in lysophosphatidic acid for bone remodeling [PDF]
Kouqiang yixueLysophosphatidic acid (LPA), a simple bioactive lysophospholipid widely dispersed in human body, has been reported to regulate the proliferation, chemotaxis and differentiation of multiple cells and further participate in various developmental and ...
ZHANG Qin, XIANG Lin, GONG Ping
doaj +1 more source
The Roles of Lpar1 in Central Nervous System Disorders and Diseases
Frontiers in Neuroscience, 2021 Lysophosphatidic acid receptor 1 (Lpar1), which is found in almost all human tissues but is most abundant in the brain, can couple to G protein-coupled receptors (GPCRs) and participate in regulating cell proliferation, migration, survival, and apoptosis.
Dongqiong Xiao +5 more
doaj +1 more source
Controlling cancer through the autotaxin–lysophosphatidic acid receptor axis [PDF]
Biochemical Society Transactions, 2012 LPA (lysophosphatidic acid, 1-acyl-2-hydroxy-sn-glycero-3-phosphate), is a growth factor-like lipid mediator that regulates many cellular functions, many of which are unique to malignantly transformed cells. The simple chemical structure of LPA and its profound effects in cancer cells has attracted the attention of the cancer therapeutics field and ...
Mari, Gotoh +14 more
openaire +3 more sources