Results 31 to 40 of about 6,064 (188)

‘Crystal’ Clear? Lysophospholipid Receptor Structure Insights and Controversies [PDF]

Trends in Pharmacological Sciences, 2018
Lysophospholipids (LPLs), particularly sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA), are bioactive lipid modulators of cellular homeostasis and pathology. The discovery and characterization of five S1P- and six LPA-specific G protein-coupled receptors (GPCRs), S1P1-5 and LPA1-6, have expanded their known involvement in all mammalian ...
Victoria A, Blaho, Jerold, Chun
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G-Protein coupled receptor signalling in pluripotent stem cell-derived cardiovascular cells: Implications for disease modelling [PDF]

, 2015
Human pluripotent stem cell derivatives show promise as an in vitro platform to study a range of human cardiovascular diseases. A better understanding of the biology of stem cells and their cardiovascular derivatives will help to understand the strengths
Dolatshad, NF, Foldes, G, Harding, SE, Hellen, N, Jabbour, R   +4 more
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Lysophospholipid Receptor-Mediated Calcium Signaling in Human Keratinocytes [PDF]

Journal of Investigative Dermatology, 2008
The lysophospholipids, sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), stimulate chemotaxis and induce differentiation of human keratinocytes. As Ca(2+) plays an important role in keratinocyte differentiation, we studied Ca(2+) signaling by S1P and LPA in these cells, known to express mRNA transcripts of the S1P(1-5) and LPA(1-3 ...
Lichte, Karin, Rossi, Roberto, Danneberg, Kerstin, Braak, Michael ter, Kürschner, Ulrich, Jakobs, Karl H., Kleuser, Burkhard, Heringdorf, Dagmar Meyer zu   +7 more
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Opposing Roles of S1P₃ Receptors in Myocardial Function

Cells, 2020
Sphingosine-1-phosphate (S1P) is a lysophospholipid mediator with diverse biological function mediated by S1P1–5 receptors. Whereas S1P was shown to protect the heart against ischemia/reperfusion (I/R) injury, other studies highlighted its ...
Dina Wafa, Nóra Koch, Janka Kovács, Margit Kerék, Richard L. Proia, Gábor J. Tigyi, Zoltán Benyó, Zsuzsanna Miklós   +7 more
doaj   +1 more source

Snake and spider toxins induce a rapid recovery of function of botulinum neurotoxin paralysed neuromuscular junction [PDF]

, 2015
Botulinum neurotoxins (BoNTs) and some animal neurotoxins (-Bungarotoxin, -Btx, from elapid snakes and -Latrotoxin, -Ltx, from black widow spiders) are pre-synaptic neurotoxins that paralyse motor axon terminals with similar clinical outcomes in patients.
Duregotti, Elisa, Megighian, Aram, Montecucco, Cesare, Pirazzini, Marco, Rigoni, Michela, Scorzeto, M., Zanetti, Giulia   +6 more
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Lysophospholipid (LPA) receptors in GtoPdb v.2023.1

IUPHAR/BPS Guide to Pharmacology CITE, 2023
Lysophosphatidic acid (LPA) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Lysophospholipid Receptors [62, 23, 91, 144]) are activated by the endogenous phospholipid LPA. The first receptor, LPA1, was identified as ventricular zone gene-1 (vzg-1) [46], This discovery represented the beginning of the de-orphanisation of members of ...
Valerie P. Tan, Manisha Ray, Tony Ngo, Yasuyuki Kihara, Jerold Chun   +4 more
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Differential expression of sphingosine-1-phosphate receptors in abdominal aortic aneurysms [PDF]

, 2012
Objective. Inflammation plays a key role in the pathophysiology of abdominal aortic aneurysms (AAAs). Newly discovered Sphingosine-1-Phosphate Receptors (S1P receptors) are critical in modulating inflammatory response via prostaglandin production.
Cheng, SWK, Cheuk, BLY, Qu, Z
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Lysophosphatidic Acid Induces Migration of Human Lung‐Resident Mesenchymal Stem Cells Through the β‐Catenin Pathway [PDF]

, 2012
Mesenchymal stem cells (MSCs) have been demonstrated to reside in human adult organs. However, mechanisms of migration of these endogenous MSCs within their tissue of origin are not well understood.
Anliker, Badri, Badri, Belperio, Bienz, Bruno, Bullions, Castelino, Cheon, Contos, Fukushima, Haegel, Harris, Hoogduijn, Hoyles, Huelsken, Humphreys, Lai, Lam, Lama, Maeda, Maijenburg, Moolenaar, Nelson, Neth, Novak, Pradere, Pradere, Rivera, Shevtsov, Tager, Tolar, Walker, Yang   +33 more
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From Classical to Alternative Pathways of 2-Arachidonoylglycerol Synthesis: AlterAGs at the Crossroad of Endocannabinoid and Lysophospholipid Signaling

Molecules
2-arachidonoylglycerol (2-AG) is the most abundant endocannabinoid (EC), acting as a full agonist at both CB1 and CB2 cannabinoid receptors. It is synthesized on demand in postsynaptic membranes through the sequential action of phosphoinositide-specific ...
Fabienne Briand-Mésange, Isabelle Gennero, Juliette Salles, Stéphanie Trudel, Lionel Dahan, Jérôme Ausseil, Bernard Payrastre, Jean-Pierre Salles, Hugues Chap   +8 more
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Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria [PDF]

, 2011
This work is licensed under the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License.-- et al.Lipid rafts and mitochondria are promising targets in cancer therapy.
Acuña, A. Ulises, Amat-Guerri, Francisco, Delgado, Javier, Gajate, Consuelo, Hornillos, Valentín, Mollinedo, Faustino, Nieto-Miguel, Teresa, Villa-Pulgarín, J. A.   +7 more
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