Results 11 to 20 of about 53,335 (249)

Metabotropic Glutamate Receptors Inhibit Microglial Glutamate Release [PDF]

ASN Neuro, 2012
Pro-inflammatory stimuli evoke an export of glutamate from microglia that is sufficient to contribute to excitotoxicity in neighbouring neurons. Since microglia also express various glutamate receptors themselves, we were interested in the potential ...
Stephen M McMullan, Bounleut Phanavanh, Gary Guo Li, Steven W Barger   +3 more
doaj   +4 more sources

Metabotropic glutamate receptors in cancer [PDF]

Neuropharmacology, 2017
Metabotropic glutamate receptors (mGluRs) are widely known for their roles in synaptic signaling. However, accumulating evidence suggests roles of mGluRs in human malignancies in addition to synaptic transmission. Somatic cell homeostasis presents intriguing possibilities of mGluRs and glutamate signaling as novel targets for human cancers.
Suzie Chen, Brian A. Wall, Janet Wangari-Talbot, Lumeng J. Yu   +3 more
openaire   +3 more sources

Metabotropic glutamate receptor trafficking [PDF]

Molecular and Cellular Neuroscience, 2018
The metabotropic glutamate receptors (mGlu receptors) are G protein-coupled receptors that bind to the excitatory neurotransmitter glutamate and are important in the modulation of neuronal excitability, synaptic transmission, and plasticity in the central nervous system.
Young Ho Suh, Kai Chang, Katherine W. Roche   +2 more
openaire   +3 more sources

Apo-state structure of the metabotropic glutamate receptor 5 transmembrane domain obtained using a photoswitchable ligand. [PDF]

Protein Sci
Abstract Metabotropic glutamate receptor 5 (mGlu5) is implicated in various neurodegenerative disorders, making it an attractive drug target. Although several ligand‐bound crystal structures of mGlu5 exist, their apo‐state crystal structure remains unknown.
Kondo Y, Hatton C, Cheng R, Trabuco M, Glover H, Bertrand Q, Stierli F, Seidel HP, Mason T, Sarma S, Tellkamp F, Kepa M, Dworkowski F, Mehrabi P, Hennig M, Standfuss J.   +15 more
europepmc   +2 more sources

Differential Epigenetic Regulation of Glutamatergic Synapse Pathway in Adults With Prenatal Exposure to Famine. [PDF]

Eur J Neurosci
Using DNA methylation data collected on adults prenatally exposed to the Chinese famine of 1959–1961, this study reports the altered epigenetic regulation in genes of the glutamate synapse pathway in association with early‐life adversity. Our analysis revealed an overall pattern of reduced DNA methylation of the pathway genes that is more pronounced in
Tan Z, Li W, Wang W, Zhang D, Tan Q.
europepmc   +2 more sources

Group III metabotropic glutamate receptors gate long-term potentiation and synaptic tagging/capture in rat hippocampal area CA2

eLife, 2020
Metabotropic glutamate receptors (mGluRs) play an important role in synaptic plasticity and memory and are largely classified based on amino acid sequence homology and pharmacological properties.
Ananya Dasgupta, Yu Jia Lim, Krishna Kumar, Nimmi Baby, Ka Lam Karen Pang, Amrita Benoy, Thomas Behnisch, Sreedharan Sajikumar   +7 more
doaj   +1 more source

mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. [PDF]

, 2018
Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood.
Bi, Guo-Hua, Gardner, Eliot L, He, Yi, Jordan, Chloe J, Li, Jie, Li, Xia, Peng, Xiao-Qing, Xi, Zheng-Xiong, Yang, Hong-Ju, Zhang, Hai-Ying   +9 more
core   +2 more sources

Optical control of metabotropic glutamate receptors [PDF]

Nature Neuroscience, 2013
G protein-coupled receptors (GPCRs), the largest family of membrane signaling proteins, respond to neurotransmitters, hormones and small environmental molecules. The neuronal function of many GPCRs has been difficult to resolve because of an inability to gate them with subtype specificity, spatial precision, speed and reversibility. To address this, we
Harald Janovjak, Harald Janovjak, Ehud Y. Isacoff, Dirk Trauner, Dirk Trauner, David Schoppik, Andreas Reiner, Benjamin M. Gaub, Joshua Levitz, Adam Hoagland, Philipp Stawski, Alexander F. Schier, Brian Kane, Carlos R. Pantoja   +13 more
openaire   +4 more sources

Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain [PDF]

, 2017
Background: L-acetylcarnitine, a drug marketed for the treatment of chronic pain, causes analgesia by epigenetically up-regulating type-2 metabotropic glutamate (mGlu2) receptors in the spinal cord.
Battaglia, Giuseppe, Bernabucci, Matteo, Bruno, Valeria Maria Gloria, Cannella, Milena, Gradini, Roberto, Imbriglio, Tiziana, Mascio, Giada, Nicoletti, Ferdinando, Notartomaso, Serena, Scarselli, Pamela, Zappulla, Cristina   +10 more
core   +1 more source

Neuronal activity patterns in the mediodorsal thalamus and related cognitive circuits are modulated by metabotropic glutamate receptors. [PDF]

, 2015
The mediodorsal thalamus (MD) likely plays an important role in cognition as it receives abundant afferent connections from the amygdala and prefrontal cortex (PFC).
Copeland, CS, Neale, SA, Salt, TE
core   +1 more source