Results 91 to 100 of about 38,001 (122)

Long-Term Treatment With Morphine Increases the D-Serine Content in the Rat Brain by Regulating the mRNA and Protein Expressions of Serine Racemase and D-Amino Acid Oxidase

Journal of Pharmacological Sciences, 2008
Recent studies indicate that an endogenous co-agonist for an N-methyl-D-aspartate (NMDA) receptor–related glycine site, D-serine, is synthesized by serine racemase and is metabolized by D-amino acid oxidase (DAO) and that acute treatment with morphine ...
Masanobu Yoshikawa, Takashi Shinomiya, Naoko Takayasu, Hideo Tsukamoto, Mitsuru Kawaguchi, Hiroyuki Kobayashi, Tetsuo Oka, Atsushi Hashimoto   +7 more
doaj  

Dizziness, nausea and progressive lethargy for two months, with mental behavior abnormality for one month

Chinese Journal of Contemporary Neurology and Neurosurgery, 2018
DOI: 10.3969/j.issn.1672-6731.2018.02 ...
Dong-hui AO, Ming YAO, Hai-tao REN, Jun NI, Li-ying CUI   +4 more
doaj  

A 16-year-old woman with fever, epilepsy and diplopia

Chinese Journal of Contemporary Neurology and Neurosurgery, 2013
Yu-yuan XU, Qing LIU, Bin PENG, Li-ying CUI   +3 more
doaj   +3 more sources

Limbic encephalitis: four cases report and review of literature

Chinese Journal of Contemporary Neurology and Neurosurgery, 2014
Objective This article aims to present clinical manifestations and to discuss the clinical features and management of 4 patients with limbic encephalitis (LE).
Fu-rong GU, Jie QIN, Xiao-lin XU
doaj  

Direct Inhibition of N-Methyl-D-Aspartate (NMDA)-Receptor Function by Antiglaucomatous β-Antagonists

Journal of Pharmacological Sciences, 2008
In the present study, we investigated the direct effects of antiglaucoma drugs (timolol, betaxolol, pilocarpine, and latanoprost) on N-methyl-D-aspartate (NMDA)-receptor function using a Xenopus oocytes expression system and electrophysiological ...
Tatsuo Nagata, Susumu Ueno, Hirofumi Morita, Toshiaki Kubota, Yumiko Toyohira, Masato Tsutsui, Akihiko Tawara, Nobuyuki Yanagihara   +7 more
doaj  

Binding Selectivity Analysis from Alchemical Receptor Hopping and Swapping Free Energy Calculations [PDF]

arXiv
We present receptor hopping and receptor swapping free energy estimation protocols based on the Alchemical Transfer Method (ATM) to model the binding selectivity of a set of ligands to two arbitrary receptors. The receptor hopping protocol, where a ligand is alchemically transferred from one receptor to another in one simulation, directly yields the ...
arxiv  

Long-term potentiation and the role of N-methyl-d-aspartate receptors

Brain Research, 2015
A. Volianskis, G. France, M. Jensen, Z. Bortolotto, D. Jane, G. Collingridge   +5 more
semanticscholar   +1 more source

New Therapeutic Strategy for Amino Acid Medicine: Glycine Improves the Quality of Sleep

Journal of Pharmacological Sciences, 2012
Glycine is a non-essential amino acid that has indispensable roles in both excitatory and inhibitory neurotransmission via N-methyl-D-aspartate type glutamate receptors and glycine receptors, respectively.
Makoto Bannai, Nobuhiro Kawai
doaj  

Discovery of GluN2A subtype-selective N-methyl-d-aspartate (NMDA) receptor ligands

Acta Pharmaceutica Sinica B
The N-methyl-d-aspartate (NMDA) receptors, which belong to the ionotropic Glutamate receptors, constitute a family of ligand-gated ion channels. Within the various subtypes of NMDA receptors, the GluN1/2A subtype plays a significant role in central ...
Liyang Jiang, Na Liu, Fabao Zhao, Boshi Huang, Dongwei Kang, Peng Zhan, Xinyong Liu   +6 more
doaj  

Calmodulin Mediates Calcium-Dependent Inactivation of N-Methyl-D-Aspartate Receptors

Neuron, 1998
Su Zhang, M. Ehlers, Jeffery P Bernhardt, C. Su, R. Huganir   +4 more
semanticscholar   +1 more source