Results 41 to 50 of about 149,284 (337)

Ketamine: NMDA receptors and beyond [PDF]

open access: yes, 2016
Human studies examining the effects of the dissociative anesthetic ketamine as a model for psychosis and as a rapidly acting antidepressant have spurred great interest in understanding ketamine's actions at molecular, cellular, and network levels ...
Izumi, Yukitoshi   +2 more
core   +2 more sources

Cellular prion protein protects from inflammatory and neuropathic pain [PDF]

open access: yes, 2011
Cellular prion protein (PrPC) inhibits N-Methyl-D-Aspartate (NMDA) receptors. Since NMDA receptors play an important role in the transmission of pain signals in the dorsal horn of spinal cord, we thus wanted to determine if PrPC null mice show a reduced ...
Gerald W Zamponi   +5 more
core   +4 more sources

Neuron-derived D-Serine Release Provides a Novel Means to Activate N-Methyl-D-aspartate Receptors*

open access: yesJournal of Biological Chemistry, 2006
d-Serine is a coagonist of N-methyl-d-aspartate (NMDA) receptors that occurs at high levels in the brain. Biosynthesis of d-serine is carried out by serine racemase, which converts l-to d-serine.
Elena Kartvelishvily   +4 more
semanticscholar   +1 more source

N-methyl-D-aspartate receptors play important roles in acquisition and expression of the eyeblink conditioned response in glutamate receptor subunit delta2 mutant mice. [PDF]

open access: yes, 2005
Classical eyeblink conditioning has been known to depend critically on the cerebellum. Apparently consistent with this, glutamate receptor subunit delta2 null mutant mice, which have serious morphological and functional deficiencies in the cerebellar ...
Fukunaga Satoshi   +6 more
core   +2 more sources

Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties

open access: yesNature Communications, 2018
N-methyl-d-aspartate-receptors (NMDARs) are glutamate receptors critical for synaptic transmission, plasticity, and cognition. Here, the authors look at four neurodevelopmental disease-related mutations of NMDAR, gaining insight into binding of Mg2+ and ...
Laura Fedele   +5 more
doaj   +1 more source

In silico analysis of binding interaction of conantokins with NMDA receptors for potential therapeutic use in Alzheimer’s disease

open access: yesJournal of Venomous Animals and Toxins including Tropical Diseases, 2017
Background The N-methyl-D-aspartate (NMDA) receptors are glutamate receptors that play vital roles in central nervous system development and are involved in synaptic plasticity, which is an essential process for learning and memory.
Maleeha Waqar, Sidra Batool
doaj   +1 more source

Candidate glutamatergic and dopaminergic pathway gene variants do not influence Huntington’s disease motor onset [PDF]

open access: yes, 2014
Huntington’s disease (HD) is a neurodegenerative disorder characterized by motor, cognitive, and behavioral disturbances. It is caused by the expansion of the HTT CAG repeat, which is the major determinant of age at onset (AO) of motor symptoms. Aberrant
Abramson, Ruth K.   +36 more
core   +1 more source

Cyclic AMP-dependent Protein Kinase and Protein Kinase C Phosphorylate N-Methyl-d-aspartate Receptors at Different Sites*

open access: yesJournal of Biological Chemistry, 1997
Ca2+ influx throughN-methyl-d-aspartate (NMDA)-type glutamate receptors plays a pivotal role in synaptic plasticity during brain development as well as in mature brain.
Soren Leonard, J. Hell
semanticscholar   +1 more source

Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors

open access: yesNature Communications, 2020
Selectively inhibiting N-Methyl-D-aspartate receptors (NMDARs) containing the GluN2C/2D subunits has been challenging. Here, using electrophysiology and X-ray crystallography, authors show that compounds UBP791 and UBP1700 show over 40- and 50-fold ...
Jue Xiang Wang   +11 more
doaj   +1 more source

Mutations of N-Methyl-D-Aspartate Receptor Subunits in Epilepsy [PDF]

open access: yesNeuroscience Bulletin, 2017
Epilepsy is one of the most common neurological diseases. Of all cases, 70%-80% are considered to be due to genetic factors. In recent years, a large number of genes have been identified as being involved in epilepsy. Among them, N-methyl-D-aspartate receptor (NMDAR) subunit-encoding genes represent a large proportion, suggesting an important role for ...
Xing-Xing Xu, Jianhong Luo
openaire   +3 more sources

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