Results 41 to 50 of about 55,585 (143)
Update in the research of anti-N-methyl-D-aspartate receptor encephalitis
Chinese Journal of Contemporary Neurology and Neurosurgery, 2014 doi: 10.3969/j.issn.1672-6731.2014.08 ...
Jia-wei WANG
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Mercury-induced toxicity of rat cortical neurons is mediated through N-methyl-D-Aspartate receptors
Molecular Brain, 2012 Background Mercury is a well-known neurotoxin implicated in a wide range of neurological or psychiatric disorders including autism spectrum disorders, Alzheimer’s disease, Parkinson’s disease, epilepsy, depression, mood disorders and tremor.
Xu Fenglian +6 more
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The GluN3 subunit regulates ion selectivity within native N-methyl-d-aspartate receptors
IBRO Reports, 2020 Glutamatergic N-methyl-d-aspartate receptors (NMDARs) are heterotetrameric proteins whose subunits are derived from three gene families, GRIN1 (codes for GluN1), GRIN2 (GluN2) and GRIN3 (GluN3).
Stephen Beesley +2 more
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Derivatives of methoxetamine and major methoxetamine metabolites potently block NMDA receptors
Journal of Pharmacological Sciences, 2022 N-Methyl-D-aspartate receptors (NMDARs) in the brain are influenced by psychoactive drugs such as 2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one (ketamine) and its analog 2-(ethylamino)-2-(3-methoxyphenyl)-cyclohexanone (methoxetamine).
Tomohiko Irie +4 more
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Chronic brain inflammation leads to a decline in hippocampal NMDA-R1 receptors
Journal of Neuroinflammation, 2004 Background Neuroinflammation plays a prominent role in the progression of Alzheimer's disease and may be responsible for degeneration in vulnerable regions such as the hippocampus.
Hauss-Wegrzyniak Beatrice +3 more
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Anti-N-methyl-D-aspartate receptor encephalitis: one case report
Chinese Journal of Contemporary Neurology and Neurosurgery, 2015 DOI: 10.3969/j.issn.1672-6731.2015.12 ...
Ying CHEN +3 more
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Brain, Behavior, & Immunity - Health, 2023 Background: Anti-NMDA-receptor GluN1 antibodies (NMDAR1-abs) are present in an autoimmune encephalitis with severe neuropsychiatric symptoms. We aimed to estimate the impact of serum NMDAR1-abs on depressive symptoms years after first-ever ischemic ...
Pia S. Sperber +11 more
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A Comprehensive Review of the Ketamine Mechanism and Its Pleiotropic Effects [PDF]
المجلة العراقية للصيدلةObjective: In the world of anesthetics, ketamine is unique. Over thirty years ago, the substance was first used in therapeutic practice to act as a "mono-anesthetic," causing analgesia, forgetfulness, loss of consciousness, and immobility.
Taqwa B. Thanoon, Zeina Althanoon
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Targeting N-Methyl-d-Aspartate Receptors in Neurodegenerative Diseases
International Journal of Molecular SciencesN-methyl-d-aspartate receptors (NMDARs) are the main class of ionotropic receptors for the excitatory neurotransmitter glutamate. They play a crucial role in the permeability of Ca2+ ions and excitatory neurotransmission in the brain. Being heteromeric receptors, they are composed of several subunits, including two obligatory GluN1 subunits (eight ...
Carles, Allison +4 more
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Dual Action of Memantine in Alzheimer Disease: A Hypothesis
Taiwanese Journal of Obstetrics & Gynecology, 2009 Objective: In this study, we proposed a hypothesis to explain the mechanisms of memantine action in treating Alzheimer disease (AD). Memantine may reduce the expression of amyloid precursor protein and tau protein, as well as acting as an antagonist of N-
Tzong-Yuan Wu, Chih-Ping Chen
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