Results 51 to 60 of about 149,284 (337)

Optimizing Angiopep‐2 Density on Polymeric Nanoparticles for Enhanced Blood–Brain Barrier Penetration and Glioblastoma Targeting: Insights From In Vitro and In Vivo Experiments

Advanced Functional Materials, EarlyView.
The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang, Ahmed Refaat, Haoqin Li, Douer Zhu, Ziqiu Tong, Joseph Anthony Nicolazzo, Bo Peng, Hua Bai, Lars Esser, Nicolas Hans Voelcker   +9 more
wiley   +1 more source

D-AMINO ACID OXIDASE: A REVIEW [PDF]

, 2016
Over many years, D-serine and glycine were found to be the endogenous ligands for glycine-binding site for N-methyl-D-aspartate receptors. D-serinebefore being used up by the cells undergoes oxidative deamination by the enzyme D-amino acid oxidase (DAAO)
Nithya S, Ts, Shanmugarajan
core   +1 more source

In developing hippocampal neurons, NR2B-containing N-methyl-d-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death [PDF]

, 2009
It has been suggested that NR2B-containing N-methyl-d-aspartate (NMDA) receptors have a selective tendency to promote pro-death signaling and synaptic depression, compared with the survival promoting, synapse potentiating properties of NR2A-containing ...
Hardingham, G.E., Martel, M.-A., Wyllie, D.J.A.   +2 more
core   +1 more source

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

Advanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson, Huy Hoang Nguyen, Keng‐Jung Lee, Nattarat Wongsuwan, Ayesha Tupe, Mengrou Lu, Mariah Lynn Arral, Anne Behre, Zihan Ling, Kathryn Ann Whitehead, Adam Walter Feinberg, Xi Ren, Si‐Yang Zheng   +12 more
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

GRIN1 Mutations in Early-Onset Epileptic Encephalopathy

Pediatric Neurology Briefs, 2015
Investigators from Yokohama City University and other medical centers in Israel and Japan reported mutations on N-methyl-D-aspartate (NMDA) receptors subunit GRIN1 (GluN1) identified in patients with nonsyndromic intellectual disability and early-onset ...
Wenjuan Chen, Hongjie Yuan
doaj   +1 more source

[Ca2+]i regulation by glutamate receptor agonists in cultured chick retina cells [PDF]

, 1996
The effect of glutamate receptor agonists on the intracellular free calcium concentration ([Ca2+]i), measured with Indo-1, was studied in populations of cultured chick embryonic retina cells.
Carvalho, Arsélio P., Duarte, Carlos B., Santos, Paulo F.   +2 more
core   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

NYX-2925 Is a Novel NMDA Receptor-Specific Spirocyclic-beta-Lactam That Modulates Synaptic Plasticity Processes Associated with Learning and Memory [PDF]

, 2018
Background: N-methyl-D-aspartate receptors are one member of a family of ionotropic glutamate receptors that play a pivotal role in synaptic plasticity processes associated with learning and have become attractive therapeutic targets for diseases such as
Cearley, Cassia, Gross, Amanda L., Houck, David R., Khan, M. Amin, Moskal, Joseph R., Stanton, Patric K., Zhang, Xiao-Lei   +6 more
core   +1 more source

Scopolamine Administration Modulates Muscarinic, Nicotinic and NMDA Receptor Systems [PDF]

, 2012
Studies on the effect of scopolamine on memory are abundant but so far only regulation of the muscarinic receptor (M1) has been reported. We hypothesized that levels of other cholinergic brain receptors as the nicotinic receptors and the N-methyl-D ...
A Blokland, A Kamsler, A Sase, AI Levey, Alev Deli, Arnold Pollak, C Lena, C Welinger, CK Lieben, D Saucier, DA Eckerman, DC Perry, DC Rogers, DM Weiner, DP Cain, DS McGehee, E Hearst, E Wezenberg, EC Burgard, EC Hulme, EG Peralta, EW Boddeke, F Bermudez-Rattoni, F Loiseau, FE Harrison, G Roldan, Georges Chapouthier, Gert Lubec, GM Cunha, GN Brito, Harald Höger, HB Li, I Klinkenberg, J Harvey, J Watts, J Wei, JC Soares, JF Zheng, JJ Boren, JJ Buccafusco, JW Kenney, L Liu, L Ma, L Mrzljak, L Robinson, LA Volpicelli, M Cordero-Erausquin, M Ghafari, M Ghafari, M Ohno, MJ Marino, MJ Marks, MP Caulfield, MW Decker, N Le Novere, N Vaisman, NI Wiener, NJ Buckley, O Buresova, O Salminen, O Salminen, P Calabresi, P Calabresi, P Chen, P Riekkinen Jr, P Whiteaker, PJ Conn, PL Carlton, PR Godding, R Rush, R Thouvarecq, R Thouvarecq, RC Hogg, RJ Lefkowitz, RS Broide, RT Bartus, RV Fornari, S Barak, S Doralp, S Irwin, S Jones, S Wonnacott, SG Anagnostaras, SJ Park, Soheil Keihan Falsafi, SS Patil, SU Kang, SV Jones, SV Ovsepian, T Schmeller, T Shinoe, TI Bonner, TI Bonner, UD Renner, WS Messer Jr, Y Kimura   +95 more
core   +4 more sources