Results 41 to 50 of about 521,660 (353)

NGF-response of EGF-dependent progenitor cells obtained from human sympathetic ganglia [PDF]

, 1994
SIGNALLING molecules are thought to play a significant role in determining the fate of neural crest progenitor cells. The human sympathetic chain was identified at 6.5, 7.5, 8.2, 10.2 and 11.4 postconception (PC) weeks demonstrating low affinity nerve ...
Ampietro, A., Bernasconi, S., Borasio, Gian Domenico, Pizzuti, A., Scarlato, G., Silani, V., Zhou, F. C.   +6 more
core   +1 more source

Nerve Growth Factor Receptor-Mediated Gene Transfer

Molecular Therapy, 2004
One obstacle to effective gene therapies for neurological disorders lies in the cell-type diversity of the nervous system, making it difficult to direct gene delivery vectors to specific types of cells. To meet this challenge, we have developed a recombinant peptide-based gene delivery vector that targets nerve growth factor (NGF) receptors.
Ma, N., Wu, S.S., Ma, Y.X., Wang, X., Zeng, J., Tong, G., Huang, Y., Wang, S.   +7 more
openaire   +2 more sources

Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]

, 2016
Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui, Hellman, Judith, Schumacher, Mark   +2 more
core   +2 more sources

Both P140TRK and P75NGFR nerve growth factor receptors mediate nerve growth factor-stimulated calcium uptake [PDF]

Neuroscience Letters, 1997
Human p140(trk) and p75(NGFR) were transfected separately into 3T3 cells. Nerve growth factor stimulates calcium uptake into both transfectants but not into untransfected 3T3 cells. p140(trk) cells were stimulated maximally by 25 ng/ml; 100 ng/ml was submaximal for p75(NGFR) cells.
H, Jiang, D S, Ulme, G, Dickens, A, Chabuk, M, Lavarreda, P, Lazarovici, G, Guroff   +6 more
openaire   +2 more sources

Nerve growth factor: two receptors, multiple functions

BioEssays, 1998
Nerve growth factor (NGF) was characterized over 4 decades ago, and like the other neurotrophins subsequently discovered, it is best known for its trophic role, including the prevention of programmed cell death in specific populations of neurones in the peripheral nervous system. This property can be accounted for by the activation of a tyrosine kinase
Frade, J. M., Barde, Y. A.
openaire   +4 more sources

Competitive Signaling Between TrkA and p75 Nerve Growth Factor Receptors Determines Cell Survival

Journal of Neuroscience, 1998
In addition to its role as a survival factor, nerve growth factor (NGF) has been implicated in initiating apoptosis in restricted cell types both during development and after terminal cell differentiation.
S. Yoon, P. Casaccia‐Bonnefil, B. Carter, M. Chao   +3 more
semanticscholar   +1 more source

P75 nerve growth factor receptors modulate development of GnRH neurons and olfactory ensheating cells

Frontiers in Neuroscience, 2013
Temporal and spatial localization of nerve growth factor receptor (p75NGFR) in the developing olfactory system and gonadotropin-releasing hormone-1 (GnRH) system was characterized and its role analyzed using p75NGFR null mice and nasal explants ...
Franca eRaucci, Jean D Tiong, Susan eWray   +2 more
doaj   +1 more source

Neurotoxicity [PDF]

, 2014
Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust, Creeley, Feldman, Grandjean, Herken, Panzica, Parent, Pessah, Rice, Román, Spencer, Spencer, Tu, Vinken, Yasui, Zawia   +15 more
core   +2 more sources

Altered Brain Expression of Insulin and Insulin-Like Growth Factors in Frontotemporal Lobar Degeneration: Another Degenerative Disease Linked to Dysregulation of Insulin Metabolic Pathways

ASN Neuro, 2019
Background Frontotemporal lobar degeneration (FTLD) is the third most common dementing neurodegenerative disease with nearly 80% having no known etiology. Objective Growing evidence that neurodegeneration can be linked to dysregulated metabolism prompted
Connie J. Liou, Ming Tong, Jean P. Vonsattel, Suzanne M. de la Monte   +3 more
doaj   +1 more source

Signalling mechanisms of long term facilitation of breathing with intermittent hypoxia. [PDF]

, 2013
Intermittent hypoxia causes long-term facilitation (LTF) of respiratory motor nerve activity and ventilation, which manifests as a persistent increase over the normoxic baseline for an hour or more after the acute hypoxic ventilatory response.
Pamenter, Matthew E, Powell, Frank L
core   +1 more source