Results 61 to 70 of about 114,328 (209)
L1CAM binds ErbB receptors through Ig-like domains coupling cell adhesion and neuregulin signalling. [PDF]
, 2012 During nervous system development different cell-to-cell communication mechanisms operate in parallel guiding migrating neurons and growing axons to generate complex arrays of neural circuits.
Baars, S +6 more
core +3 more sources
Notch receptors in human choroid plexus tumors.
Histology and histopathology, 2013 Notch signaling plays a role in development and formation of the normal choroid plexus (nCP), and in formation of various tumors in humans. Activation of Notch3 has been reported to promote tumor growth in invasive gliomas and to initiate formation of choroid plexus tumors (CPT) in mice.
Waidelich, Johannes Maximilian +4 more
openaire +3 more sources
Calcium Depletion Dissociates and Activates Heterodimeric Notch Receptors [PDF]
Molecular and Cellular Biology, 2000 Notch receptors participate in a highly conserved signaling pathway that regulates morphogenesis in multicellular animals. Maturation of Notch receptors requires the proteolytic cleavage of a single precursor polypeptide to produce a heterodimer composed of a ligand-binding extracellular domain (N(EC)) and a single-pass transmembrane signaling domain ...
M D, Rand +6 more
openaire +2 more sources
European Journal of Medical Research, 2010 Background Notch receptors are critical determinants of cell fate in a variety of organisms. Notch signaling is involved in the chondrogenic specification of neural crest cells.
Siar CH +7 more
doaj +1 more source
Normal sleep bouts are not essential for C. elegans survival and FoxO is important for compensatory changes in sleep [PDF]
, 2018 Additional file 6: Decreased lag-2 function does not slow vulval development. The progeny of wild type and lag-2(q420) animals raised at 25.5 °C were selected at the L4 stage, prior to lethargus entry. Vulval eversion was scored after 3 h; the percentage
Bennett, Heather L +7 more
core +4 more sources
PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner [PDF]
Cell Research, 2014 Activation of Notch signaling requires intracellular routing of the receptor, but the mechanisms controlling the distinct steps in the routing process is poorly understood. We identify PKCζ as a key regulator of Notch receptor intracellular routing. When PKCζ was inhibited in the developing chick central nervous system and in cultured myoblasts, Notch ...
Sjöqvist, M. +12 more
openaire +2 more sources
Cellular networks controlling Th2 polarization in allergy and immunity [PDF]
, 2012 In contrast to the development of Th1 (type 1 T helper cells), Th17 and Treg (regulatory T cells), little is known of the mechanisms governing Th2 development, which is important for immunity to helminths and for us to understand the pathogenesis of ...
Kool, Mirjam +2 more
core +1 more source
The Notch Pathway in Breast Cancer Progression
The Scientific World Journal, 2018 Objective. Notch signaling pathway is a vital parameter of the mammalian vascular system. In this review, the authors summarize the current knowledge about the impact of the Notch signaling pathway in breast cancer progression and the therapeutic role of
Emmanuel N. Kontomanolis +6 more
doaj +1 more source
Chemotactic Cues for NOTCH1-Dependent Leukemia [PDF]
, 2018 The NOTCH signaling pathway is a conserved signaling cascade that regulates many aspects of development and homeostasis in multiple organ systems.
Amadori, Alberto +3 more
core +1 more source
Nuclear βII-Tubulin Associates with the Activated Notch Receptor to Modulate Notch Signaling [PDF]
Cancer Research, 2004 Abstract The Notch signal pathway plays important roles in proliferation, apoptosis, and differentiation. Abnormalities in Notch signaling are linked to many human diseases. After ligand binding, Notch signaling is activated through the cleavage of Notch receptors to release and translocate the Notch intracellular domain into the nucleus.
Tien-Shun, Yeh +6 more
openaire +2 more sources