Results 61 to 70 of about 2,492,882 (302)
Cucurbitacin B and I inhibits colon cancer growth by targeting the Notch signaling pathway
Scientific Reports, 2020 Cancer stem cells (CSCs) have the ability to self-renew and induce drug resistance and recurrence in colorectal cancer (CRC). As current chemotherapy doesn’t eliminate CSCs completely, there is a need to identify novel agents to target them.
P. Dandawate +10 more
semanticscholar +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Cis-activation in the Notch signaling pathway
eLife, 2019 The Notch signaling pathway consists of transmembrane ligands and receptors that can interact both within the same cell (cis) and across cell boundaries (trans). Previous work has shown that cis-interactions act to inhibit productive signaling.
Nagarajan Nandagopal +2 more
doaj +1 more source
Redundant Notch1 and Notch2 signaling is necessary for IFNγ secretion by T helper 1 cells during infection with Leishmania major. [PDF]
PLoS Pathogens, 2012 The protective immune response to intracellular parasites involves in most cases the differentiation of IFNγ-secreting CD4(+) T helper (Th) 1 cells.
Floriane Auderset +8 more
doaj +1 more source
Development, 2012 In the developing lung, it is thought that the terminal buds of elongating airways contain a population of multipotent epithelial progenitors. As the bronchial tree extends, descendants of these cells give rise to lineage-restricted progenitors in the ...
M. Morimoto +3 more
semanticscholar +1 more source
Engineering of an enhanced synthetic Notch receptor by reducing ligand-independent activation
Communications Biology, 2020 Notch signaling is highly conserved in most animals and plays critical roles during neurogenesis as well as embryonic development. Synthetic Notch-based systems, modeled from Notch receptors, have been developed to sense and respond to a specific ...
Zijie Yang +4 more
semanticscholar +1 more source
Notch receptors in human choroid plexus tumors.
Histology and histopathology, 2013 Notch signaling plays a role in development and formation of the normal choroid plexus (nCP), and in formation of various tumors in humans. Activation of Notch3 has been reported to promote tumor growth in invasive gliomas and to initiate formation of choroid plexus tumors (CPT) in mice.
Waidelich, Johannes Maximilian +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
THE ROLE OF NOTCH PATHWAY IN CARCINOGENESIS
Успехи молекулярной онкологии, 2015 Notch transmembrane receptors family in humans consists of 4 proteins (Notch1–4) which are activated upon direct contact of cells, carrying appropriate ligands of Jagged or Dll families.
M. V. Novikova +4 more
doaj +1 more source
PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner [PDF]
Cell Research, 2014 Activation of Notch signaling requires intracellular routing of the receptor, but the mechanisms controlling the distinct steps in the routing process is poorly understood. We identify PKCζ as a key regulator of Notch receptor intracellular routing. When PKCζ was inhibited in the developing chick central nervous system and in cultured myoblasts, Notch ...
Sjöqvist, M. +12 more
openaire +2 more sources