Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells [PDF]
, 2016 Indexación: Web of ScienceTumor angiogenesis is widely recognized as one of the hallmarks of cancer. Consequently, during the last decades the development and testing of commercial angiogenic inhibitors has been a central focus for both basic and ...
Carrasco-Avino, G +4 more
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Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and b1-integrin activation [PDF]
, 2018 Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood.
Alve, S +17 more
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Intermediate progenitors support migration of neural stem cells into dentate gyrus outer neurogenic niches. [PDF]
, 2020 The hippocampal dentate gyrus (DG) is a unique brain region maintaining neural stem cells (NCSs) and neurogenesis into adulthood. We used multiphoton imaging to visualize genetically defined progenitor subpopulations in live slices across key stages of ...
Arnold, Sebastian J +6 more
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CARMA1 is a novel regulator of T-ALL disease and leukemic cell migration to the CNS [PDF]
, 2017 No abstract ...
A de Lourdes Perim +14 more
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Notch Signalling: Receptor cis-Inhibition To Achieve Directionality [PDF]
Current Biology, 2009 Lateral inhibition, by which single cells become distinct from their neighbours, can be mediated by Notch signalling during animal development. Signalling directionality is presumably achieved by downregulation of the Notch ligand in signal-receiving cells.
del Álamo, David +1 more
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Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression [PDF]
, 2012 Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Abramsson +79 more
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Control of Notch-ligand endocytosis by ligand-receptor interaction [PDF]
Development, 2010 In Notch signaling, cell-bound ligands activate Notch receptors on juxtaposed cells, but the relationship between ligand endocytosis, ubiquitylation and ligand-receptor interaction remains poorly understood. To study the specific role of ligand-receptor interaction, we identified a missense mutant of the Notch ligand Jagged1 (Nodder, Ndr) that failed ...
Hansson, E. M. +10 more
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Non-small-cell lung carcinoma: role of the Notch signaling pathway
Lung Cancer: Targets and Therapy, 2015 Levi Barse, Maurizio Bocchetta Department of Pathology, Oncology Institute, Loyola University Chicago, Maywood, IL, USA Abstract: Notch signaling plays a pivotal role during embryogenesis.
Barse L, Bocchetta M
doaj
Notch2 signaling sensitizes endothelial cells to apoptosis by negatively regulating the key protective molecule survivin. [PDF]
PLoS ONE, 2009 BackgroundNotch signaling pathway controls key functions in vascular and endothelial cells (ECs) where Notch4 plays a major role. However, little is known about the contribution of other Notch receptors.
Thibaut Quillard +7 more
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The Notch system during pubertal development of the bovine mammary gland
Scientific Reports, 2019 The development of the mammary gland of cows during pre-weaning and puberty will condition its future productive capacity and warrants special study. In this respect, Notch signaling regulates tissue development and fate by modifying cell proliferation ...
Nadia Bonadeo +3 more
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