Results 81 to 90 of about 2,492,882 (302)

Multifaceted regulation of Notch signaling by glycosylation.

Glycobiology, 2020
To build a complex body composed of various cell types and tissues and to maintain tissue homeostasis in the post-embryonic period, animals use a small number of highly conserved intercellular communication pathways.
A. Pandey, N. Niknejad, H. Jafar-Nejad
semanticscholar   +1 more source

Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand

PLOS ONE, 2016
Delta/Notch-like EGF-related receptor (DNER) has been reported to act as a Notch ligand, despite lacking a Delta/Serrate/Lag (DSL) binding domain common to all other known ligands. The established Notch ligand Delta-like 1 (DLL1), but not DNER, activated Notch1 in a luciferase assay, prevented the differentiation of myoblasts through Notch signaling ...
Maxwell Greene, Yongjie Lai, Kostandin Pajcini, Will Bailis, Warren S. Pear, Eric Lancaster   +5 more
openaire   +4 more sources

Functional conservation of mouse Notch receptor family members [PDF]

FEBS Letters, 1996
All the known members of the mouse Notch receptor family were examined for their biochemical function by interaction with a DNA binding protein RBP‐Jκ. mNotch2, mNotch3 and int3 (= mNotch4) were shown to interact with RBP‐Jκ by the GST‐fusion pull down assay and dominant negative competition with Epstein Barr virus nuclear antigen 2.
Kato, Hisamune, Sakai, Takashi, Tamura, Kumiko, Minoguchi, Shigeru, Shirayoshi, Yasuaki, Hamada, Yoshio, Tsujimoto, Yoshihide, Honjo, Tasuku   +7 more
openaire   +2 more sources

Cancer-associated Notch receptor variants lead to O-fucosylation defects that deregulate Notch signaling

Journal of Biological Chemistry, 2022
NOTCH1 is a transmembrane receptor that initiates a signaling pathway involved in embryonic development of adult tissue homeostasis. The extracellular domain of NOTCH1 is composed largely of epidermal growth factor-like repeats (EGFs), many of which can be O-fucosylated at a specific consensus sequence by protein O-fucosyltransferase 1 (POFUT1).
Florian Pennarubia, Atsuko Ito, Megumi Takeuchi, Robert S. Haltiwanger   +3 more
openaire   +2 more sources

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Molecular pathways of Notch signaling in vascular smooth muscle cells

Frontiers in Physiology, 2012
Notch signaling in the cardiovascular system is important during embryonic development, vascular repair of injury, and vascular pathology in humans. The vascular smooth muscle cell (VSMC) expresses multiple Notch receptors throughout its life cycle, and ...
Joshua M. Boucher, Joshua M. Boucher, Thomas eGridley, Lucy eLiaw   +3 more
doaj   +1 more source

Micropatterned Biphasic Printed Electrodes for High‐Fidelity on‐Skin Bioelectronics

Advanced Functional Materials, EarlyView.
Micropatterned biphasic printed electrodes achieve unprecedented skin conformity and low impedance by combining liquid‐metal droplets with microstructured 3D lattices. This scalable approach enables high‐fidelity detection of ECG, EMG, and EEG signals, including alpha rhythms from the forehead, with long‐term comfort and stability.
Manuel Reis Carneiro, Telmo Lopes, André F. Silva, Carmel Majidi, Mahmoud Tavakoli   +4 more
wiley   +1 more source

Mathematical analysis of the effect of portal vein cells on biliary epithelial cell differentiation through the Delta-Notch signaling pathway

BMC Research Notes, 2021
Objective The Delta-Notch signaling pathway induces fine-grained patterns of differentiation from initially homogeneous progenitor cells in many biological contexts, including Drosophila bristle formation, where mathematical modeling reportedly suggests ...
Masaharu Yoshihara, Teppei Nishino, Manoj Kumar Yadav, Akihiro Kuno, Takeshi Nagata, Hiroyasu Ando, Satoru Takahashi   +6 more
doaj   +1 more source

A Smart Magnetically Actuated Flip‐Disc Programmable Metasurface with Ultralow Power Consumption for Real‐Time Channel Control

Advanced Functional Materials, EarlyView.
The study proposes a 1‐bit programmable metasurface based on flip‐disc display, named flip‐disc metasurface (FD‐MTS). This new design enables ultralow energy consumption while maintaining coding patterns. It also exhibits high scalability and multifunctional flexibility.
Jiang Han Bao, Che Liu, Jia Cheng Li, Zhen Hao Fu, Yi Su Huang, Si Qi Huang, Lei Zhang, Jian Wei You, Tie Jun Cui   +8 more
wiley   +1 more source

Notch Signalling: Receptor cis-Inhibition To Achieve Directionality [PDF]

Current Biology, 2009
Lateral inhibition, by which single cells become distinct from their neighbours, can be mediated by Notch signalling during animal development. Signalling directionality is presumably achieved by downregulation of the Notch ligand in signal-receiving cells.
del Álamo, David, Schweisguth, François   +1 more
openaire   +2 more sources