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Purinergic and Calcium Signaling in Macrophage Function and Plasticity [PDF]

Frontiers in Immunology, 2014
In addition to a fundamental role in cellular bioenergetics, the purine nucleotide adenosine triphosphate (ATP) plays a crucial role in the extracellular space as a signaling molecule.
Bimal N Desai, Norbert Leitinger
exaly   +5 more sources

Purinergic Signaling in Liver Pathophysiology

Frontiers in Endocrinology, 2021
Extracellular nucleosides and nucleotides activate a group of G protein-coupled receptors (GPCRs) known as purinergic receptors, comprising adenosine and P2Y receptors. Furthermore, purinergic P2X ion channels are activated by ATP.
Shanu Jain, Kenneth A Jacobson
exaly   +3 more sources

Purine and purinergic receptors in health and disease

MedComm, 2023
Purines and purinergic receptors are widely distributed throughout the human body. Purine molecules within cells play crucial roles in regulating energy metabolism and other cellular processes, while extracellular purines transmit signals through ...
Yanling Ai, Hengyi Wang, Lu Liu, Yulin Qi, Shiyun Tang, Jianyuan Tang, Nianzhi Chen   +6 more
doaj   +3 more sources

Purinergic Signaling During Hyperglycemia in Vascular Smooth Muscle Cells

Frontiers in Endocrinology, 2020
The activation of purinergic receptors by nucleotides and/or nucleosides plays an important role in the control of vascular function, including modulation of vascular smooth muscle excitability, and vascular reactivity.
Miguel Martín-aragón Baudel, Madeline Nieves-cintrón, Manuel F Navedo   +2 more
exaly   +3 more sources

Purinergic Regulation of Neutrophil Function

Frontiers in Immunology, 2018
Purinergic signaling, which utilizes nucleotides (particularly ATP) and adenosine as transmitter molecules, plays an essential role in immune system. In the extracellular compartment, ATP predominantly functions as a pro-inflammatory molecule through ...
Xu Wang
exaly   +3 more sources

Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma?

Frontiers in Allergy, 2021
Extracellular ATP functions as a signaling messenger through its actions on purinergic receptors, and is known to be involved in numerous physiological and pathophysiological processes throughout the body, including in the lungs and airways. Consequently,
Rebecca J. Thompson, Ian Sayers, Katja Kuokkanen, Ian P. Hall   +3 more
doaj   +1 more source

Purinergic signaling in the male reproductive tract

Frontiers in Endocrinology, 2022
Purinergic receptors are ubiquitously expressed throughout the body and they participate in the autocrine and paracrine regulation of cell function during normal physiological and pathophysiological conditions.
Larissa Berloffa Belardin, Kéliane Brochu, Christine Légaré, Maria Agustina Battistone, Sylvie Breton   +4 more
doaj   +1 more source

Purinergic P2 Receptors: Novel Mediators of Mechanotransduction

Frontiers in Pharmacology, 2021
Mechanosensing and mechanotransduction are vital processes in mechanobiology and play critical roles in regulating cellular behavior and fate. There is increasing evidence that purinergic P2 receptors, members of the purinergic family, play a crucial ...
Qihang Kong, Yue Quan, Geer Tian, Junteng Zhou, Xiaojing Liu, Xiaojing Liu   +5 more
doaj   +1 more source

Purinergic receptors are a key bottleneck in tumor metabolic reprogramming: The prime suspect in cancer therapeutic resistance

Frontiers in Immunology, 2022
ATP and other nucleoside phosphates have specific receptors named purinergic receptors. Purinergic receptors and ectonucleotidases regulate various signaling pathways that play a role in physiological and pathological processes.
Hamid Aria, Hamid Aria, Marzieh Rezaei, Shima Nazem, Abdolreza Daraei, Ghasem Nikfar, Behnam Mansoori, Maryam Bahmanyar, Alireza Tavassoli, Mohammad Kazem Vakil, Yaser Mansoori, Yaser Mansoori   +11 more
doaj   +1 more source

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source