Results 51 to 60 of about 26,672 (188)
Characterization of ionotrophic purinergic receptors in hepatocytes [PDF]
Hepatology, 2008 Ionotrophic purinergic (P2X) receptors function as receptor-gated cation channels, where agonist binding leads to opening of a nonselective cation pore permeable to both Na+ and Ca2+. Based on evidence that extracellular adenosine 5′-triphosphate (ATP) stimulates glucose release from liver ...
Gordan Kilic +8 more
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Frontiers in Neuroscience, 2009 Vasoactive intestinal peptide (VIP) immunoreactive secretomotor neurons in the submucous plexus are involved in mediating bacterial toxin-induced hypersecretion leading to diarrhoea.
Jaime Pei Pei Foong, Joel C Bornstein
doaj +1 more source
Cells, 2023 In the cerebral cortex, glutamate activates NMDA receptors (NMDARs), localized in noradrenergic neurons, inducing noradrenaline release that may have a permissive effect on glutamatergic transmission, and therefore, on the modulation of long-term ...
Clara Quintas +2 more
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The impact of high density receptor clusters on VEGF signaling [PDF]
EPTCS 125, 2013, pp. 37-52, 2013 Vascular endothelial growth factor (VEGF) signaling is involved in the process of blood vessel development and maintenance. Signaling is initiated by binding of the bivalent VEGF ligand to the membrane-bound receptors (VEGFR), which in turn stimulates receptor dimerization.
arxiv +1 more source
The role of the purinergic P2X7 receptor in inflammation [PDF]
Journal of Inflammation, 2007 AbstractThe inflammatory process, orchestrated against a variety of injurious stimuli, is composed of three inter-related phases; initiation, propagation and resolution. Understanding the interplay between these three phases and harnessing the beneficial properties of inflammation whilst preventing its damaging effects, will undoubtedly lead to the ...
Lister, Martin F +6 more
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Purinergic Signaling in the Pathophysiology and Treatment of Huntington’s Disease
Frontiers in Neuroscience, 2021 Huntington’s disease (HD) is a devastating, progressive, and fatal neurodegenerative disorder inherited in an autosomal dominant manner. This condition is characterized by motor dysfunction (chorea in the early stage, followed by bradykinesia, dystonia ...
Melissa Talita Wiprich +4 more
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Role of purinergic receptors in the Alzheimer’s disease [PDF]
Purinergic Signalling, 2018 AbstractEtiology of the Alzheimer’s disease (AD) is not fully understood. Different pathological processes are considered, such as amyloid deposition, tau protein phosphorylation, oxidative stress (OS), metal ion disregulation, or chronic neuroinflammation. Purinergic signaling is involved in all these processes, suggesting the importance of nucleotide
Marek Cieślak, Andrzej Wojtczak
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Brain Sciences, 2023 Recent data suggest that defects in purinergic signalling are a common denominator of autism spectrum disorders (ASDs), though nothing is known about whether the disorder-related imbalance occurs at the receptor level.
Lidia Babiec +5 more
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A Thermodynamic Model for Receptor Clustering [PDF]
, 1999 Intracellular signaling often arises from ligand-induced oligomerization of cell surface receptors. This oligomerization or clustering process is fundamentally a cooperative behavior between near-neighbor receptor molecules; the properties of this cooperative process clearly affects the signal transduction.
arxiv +1 more source
High- and low-conductance NMDA receptors are present in layer 4 spiny stellate and layer 2/3 pyramidal neurons of mouse barrel cortex [PDF]
Physiological Reports, 30th Dec. 2016, Vol. 4 no. e13051, 2016 NMDA receptors are ion channels activated by the neurotransmitter glutamate in the mammalian brain and are important in synaptic function and plasticity, but are also found in extrasynaptic locations and influence neuronal excitability. There are different NMDA receptor subtypes which differ in their single-channel conductance.
arxiv +1 more source