Results 21 to 30 of about 8,524 (163)

Extracellular ATP released by osteoblasts is a key local inhibitor of bone mineralisation [PDF]

, 2013
Previous studies have shown that exogenous ATP (>1µM) prevents bone formation in vitro by blocking mineralisation of the collagenous matrix. This effect is thought to be mediated via both P2 receptor-dependent pathways and a receptor-independent ...
A Brandao-Burch, A Brandao-Burch, A Gartland, A Hoebertz, BA Evans, CG Bellows, DC Genetos, DC Genetos, E Nakamura, G Burnstock, G Burnstock, G Burnstock, G Burnstock, H Fleisch, H Fleisch, H Zimmermann, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, Isabel R. Orriss, J Ham, JL Ramírez-Zacarías, JP Reyes, KA Buckley, KA Buckley, KA Johnson, L Hessle, Luc Malaval, M Ciciarello, M Romanello, Mark O. R. Hajjawi, Michelle L. Key, MP Abbracchio, MW Pfaffl, N Panupinthu, N Panupinthu, N Wang, N Zippel, RM Rumney, S Shimegi, S Syberg, Timothy R. Arnett, V Ralevic, WB Bowler, WE Razzell, WN Addison   +49 more
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Purinergic mechanosensory transduction and visceral pain [PDF]

, 2009
In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain.
Burnstock, G
core   +3 more sources

Purinergic Receptors in Adipose Tissue As Potential Targets in Metabolic Disorders

Frontiers in Pharmacology, 2017
Extracellular nucleosides and nucleotides, such as adenosine and adenosine triphosphate (ATP), are involved in many physiological and pathological processes in adipose tissue (AT).
Marco Tozzi, Ivana Novak
doaj   +1 more source

Purinergic signalling pathway: therapeutic target in ovarian cancer

Egyptian Journal of Medical Human Genetics, 2020
Background The lack of early diagnostic tools and the development of chemoresistance have made ovarian cancer (OC) one of the deadliest gynaecological cancers.
Nisha Chandran, Mahalaxmi Iyer, Zothan Siama, Balachandar Vellingiri, Arul Narayanasamy   +4 more
doaj   +1 more source

Ontogeny of purinergic receptor-regulated Ca2+ signaling in mouse cortical collecting duct epithelium [PDF]

, 2002
Changes in ATP-induced increase in {[}Ca2+], during collecting duct ontogeny were studied in primary monolayer cultures of mouse ureteric bud (UB) and cortical collecting duct (CCD) cells by Fura-PE3 fluorescence ratio imaging.
Borscheid, R., Braun, G. S., Horster, M. F., Huber, S. M., Tschop, J.   +4 more
core   +1 more source

Role of purinergic signalling in obesity-associated end-organ damage: focus on the effects of natural plant extracts

Frontiers in Endocrinology, 2023
Obesity has become one of the major public health problems in both the developing and developed countries. Recent studies have suggested that the purinergic signalling is involved in obesity-associated end-organ damage through purine P1 and P2 receptors.
Hangxiu Che, Hangxiu Che, Yaqun Wang, Jinhui Lao, Yixin Deng, Chirui Xu, Hanxiao Yin, Zheng Tang, Yonghong Huang, Hong Xu   +9 more
doaj   +1 more source

Purinergic mechanisms in neuroinflammation: An update from molecules to behavior. [PDF]

, 2015
The principle functions of neuroinflammation are to limit tissue damage and promote tissue repair in response to pathogens or injury. While neuroinflammation has utility, pathophysiological inflammatory responses, to some extent, underlie almost all ...
Beamer, Edward, Bekő, Katinka, Gölöncsér, Flóra, Horváth, Gergely, Koványi, Bence, Otrokocsi, Lilla, Sperlágh, Beáta   +6 more
core   +1 more source

Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death [PDF]

, 2010
The purinergic signalling system, which uses purines and pyrimidines as chemical transmitters, and purinoceptors as effectors, is deeply rooted in evolution and development and is a pivotal factor in cell communication.
A Gartland, A Hoebertz, A Surprenant, A Trautmann, A Verkhratsky, AN Drury, AV Gourine, AV Greig, AV Greig, AV Greig, AV Greig, AV Greig, AV Greig, B Hechler, B Johansson, B Vandewalle, BB Fredholm, BB Fredholm, BS Khakh, BS Khakh, C Giaume, C Ledent, C Ponnamperuma, CA Salvatore, CH Fiske, CI Seye, CJ Dixon, D Erlinge, DA Cockayne, E Ghanem, E Rapaport, EB Gonzales, EW Inscho, EW Sutherland, F Di Virgilio, F Di Virgilio, F Di Virgilio, F Lippman, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Burnstock, G Clark, H Franke, H Woodward, H Zimmermann, HZ Ke, I Bar, IF Gow, IP Chessell, J Korcok, J Li, J Nilsson, JA Burgers, JA Sim, JE Wilson, JF Chen, JF Chen, JL Madara, JM Armstrong, JM Sanz, JT Neary, K Inoue, K Inoue, K Inoue, K Lohmann, K Mulryan, K Wirkner, K Yamamoto, KA Moore, L Gimenez-Llort, L Li, M Horckmans, M Naassila, M Ryten, M Shabbir, M Shabbir, M Shabbir, M Sugioka, M Tsuda, MJ Bours, MJ Ludlow, MM Waldrop, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Abbracchio, MP Meyer, MW Grol, MW Verghese, MY Avila, N Lenain, N Panupinthu, N White, N White, N White, PB Conley, R Brown, R Janssens, RA North, RA North, RJ Cerniway, S Kirischuk, S Kirischuk, S Pochet, S Ryzhov, SD Ohlendorff, SJ Fountain, SJ Fountain, SL Tilley, T Kawate, TE Finger, U Groschel-Stewart, U Groschel-Stewart, UK Hanisch, V Ralevic, V Ralevic, V Souslova, VL Cressman, X Bian, X Hua, Y Guo, Y Pankratov, Y Pankratov, Y Pankratov, Y Pankratov, YD Bogdanov, Z Xiang, Z Zhao   +139 more
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Mitogenic signaling from P1 and P2 purinergic receptors to mitogen-activated protein kinase in human fetal astrocyte cultures

Neuroscience Letters, 1998
To investigate potential trophic actions of extracellular ATP in human astrocytes, we have examined mitogenic signaling by purinergic receptors in cultures prepared from first trimester rostral central nervous system tissue. We found that ATP and ATPgammaS, a hydrolysis-resistant analog, stimulated DNA synthesis, thereby indicating that P2 purinergic ...
J T, Neary, M, McCarthy, Y, Kang, S, Zuniga   +3 more
openaire   +2 more sources

ATP as a presynaptic modulator [PDF]

, 2000
© 2000 Elsevier Science Inc.There is considerable evidence that ATP acts as a fast transmitter or co-transmitter in autonomic and sensory nerves mostly through activation of ionotropic P2X receptors but also through metabotropic P2Y receptors. By analogy,
Cunha, Rodrigo A., Ribeiro, J. A.
core   +1 more source