Results 21 to 30 of about 22,494 (202)

Uridine adenosine tetraphosphate (Up4A) as a novel coronary vasodilator in health and disease: Role of purinergic P1 and P2 receptors

The FASEB Journal, 2012
Up4A is a potent endothelium‐derived contracting factor that contains purine and pyrimidine moieties and activates purinergic P2X and P2Y receptors. Up4A has recently been found to also have vasodilator effects. Here, we evaluated Up4A in isolated coronary small arteries from normal (N) swine and swine after myocardial infarction ...
Zhichao Zhou, Dirk Jan Duncker, Daphne Merkus   +2 more
openaire   +2 more sources

Functions of Purinergic Receptors [PDF]

Receptors P1 and P2 as Targets for Drug Therapy in Humans, 2019
Purinergic receptors, also known as purinoceptors, are a family of plasma membrane molecules found in many mammalian tissues. Purinergic receptors are transmembrane receptors consisting of two main categories.
Sarikaya, Eren
core   +3 more sources

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease. [PDF]

J Trop Med
Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Pereira CSF, Faria RX.
europepmc   +2 more sources

Purinergic enzymes on extracellular vesicles: immune modulation on the go

Frontiers in Immunology
An increase in the extracellular concentration of ATP as a consequence of cellular stress or cell death results in the activation of immune cells. To prevent inflammation, extracellular ATP is rapidly metabolized to adenosine, which deploys an anti ...
Riekje Winzer, Du Hanh Nguyen, Felix Schoppmeier, Felix Schoppmeier, Filippo Cortesi, Filippo Cortesi, Nicola Gagliani, Nicola Gagliani, Eva Tolosa   +8 more
doaj   +2 more sources

Adenosine receptors as emerging therapeutic targets for diabetic kidney disease [PDF]

Kidney Research and Clinical Practice, 2022
Diabetic kidney disease (DKD) is now a pandemic worldwide, and novel therapeutic options are urgently required. Adenosine, an adenosine triphosphate metabolite, plays a role in kidney homeostasis through interacting with four types of adenosine receptors
Eun Seon Pak, Jin Joo Cha, Dae Ryong Cha, Keizo Kanasaki, Hunjoo Ha   +4 more
doaj   +1 more source

Ectonucleotidases and purinergic receptors in mouse prostate gland. [PDF]

Am J Clin Exp Urol
OBJECTIVES Extracellular ATP/ADP and its metabolite adenosine play crucial roles in cellular signaling by interacting with P2 and P1/adenosine receptors.
Yu J, Sharkey C, Olumi AF, Wang Z.
europepmc   +3 more sources

Purinergic signaling: Diverse effects and therapeutic potential in cancer

Frontiers in Oncology, 2023
Regardless of improved biological insights and therapeutic advances, cancer is consuming multiple lives worldwide. Cancer is a complex disease with diverse cellular, metabolic, and physiological parameters as its hallmarks.
Jasmeet Kaur, Sanchit Dora
doaj   +1 more source

Expression profiles of purinergic P1 and P2 receptors in cultured bovine aortic endothelial cells, bovine aortic smooth muscle cells, and human vascular endothelial EA.hy926 cells

The Journal of Toxicological Sciences
Purinergic signaling plays an important role in vascular biology by vascular tone, inflammation, and remodeling through extracellular nucleotides that activate the P1 and P2 receptors.
Lihito Ikeuchi, Takato Hara, Kazuki Kitabatake, Fumiaki Uchiumi, Chika Yamamoto, Mitsutoshi Tsukimoto, Tomoya Fujie, Toshiyuki Kaji   +7 more
openaire   +2 more sources

The adenosinergic machinery in cancer: In-tandem insights from basic mechanisms to therapy

Frontiers in Immunology, 2023
Extracellular adenosine (eADO) signaling has emerged as an increasingly important regulator of immune responses, including tumor immunity. eADO is mainly produced from extracellular ATP (eATP) hydrolysis.
Chifei Kang, Chifei Kang, Luyu Liu, Chengyu Wu, Lingyun Li, Xiao Jia, Wendi Xie, Siyu Chen, Xinying Wu, Huaxiao Zheng, Jingxin Liu, Rongsong Li, Bin Zeng   +12 more
doaj   +1 more source

Role of P1 purinergic receptors in myocardial ischemia sensory transduction [PDF]

Cardiovascular Research, 2002
To characterize the role that cardiac sensory P(1) purinergic (adenosine A(1) or A(2)) receptors play in transducing myocardial ischemia.Porcine nodose ganglion cardiac sensory neuron adenosine A(1) or A(2) receptor function was studied in situ during control states as well as in the presence of the peptides bradykinin and substance P or focal ...
G W, Thompson, M, Horackova, J A, Armour
openaire   +2 more sources