Results 31 to 40 of about 7,951 (196)

Purinergic Signaling and Dental Orofacial Pain [PDF]

, 2019
Pain is a common complaint of patients in the dental clinic. Patient with dental orofacial pain usually presents with hyperalgesia and allodynia.
Liu, Xiuxin
core   +2 more sources

Adenosine Receptor Signaling in Diseases with Focus on Cancer

Jorjani Biomedicine Journal, 2022
Various investigation has shown the magnitude role of adenosine receptors in cancer development. The A1, A2A, A2B, and A3 G-protein-coupled cell surface Adenosine Receptors (ARs) are found to be upregulated in many types of cancers.
Mahmood Poorjam, zeinab mohammadi, Seyyed Mehdi Jafari   +2 more
doaj  

Purinergic mechanosensory transduction and visceral pain [PDF]

, 2009
In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain.
Burnstock, G
core   +3 more sources

Alzheimer and Purinergic Signaling: Just a Matter of Inflammation?

Cells, 2021
Alzheimer’s disease (AD) is a widespread neurodegenerative pathology responsible for about 70% of all cases of dementia. Adenosine is an endogenous nucleoside that affects neurodegeneration by activating four membrane G protein-coupled receptor subtypes,
Stefania Merighi, Tino Emanuele Poloni, Anna Terrazzan, Eva Moretti, Stefania Gessi, Davide Ferrari   +5 more
doaj   +1 more source

Uridine adenosine tetraphosphate (Up4A) as a novel coronary vasodilator in health and disease: Role of purinergic P1 and P2 receptors

The FASEB Journal, 2012
Up4A is a potent endothelium‐derived contracting factor that contains purine and pyrimidine moieties and activates purinergic P2X and P2Y receptors. Up4A has recently been found to also have vasodilator effects. Here, we evaluated Up4A in isolated coronary small arteries from normal (N) swine and swine after myocardial infarction (MI), and studied the ...
Zhichao Zhou, Daphne Merkus, Dirk J. Duncker   +2 more
openaire   +1 more source

Purinergic Signaling in Kidney Disease [PDF]

, 2016
Nucleotides are key subunits for nucleic acids and provide energy for intracellular metabolism. They can also be released from cells to act physiologically as extracellular messengers or pathologically as danger signals.
Bailey, Matthew, Menzies, Robert, Tam, Frederick W K, Unwin, Robert J   +3 more
core   +2 more sources

Extracellular ATP released by osteoblasts is a key local inhibitor of bone mineralisation [PDF]

, 2013
Previous studies have shown that exogenous ATP (>1µM) prevents bone formation in vitro by blocking mineralisation of the collagenous matrix. This effect is thought to be mediated via both P2 receptor-dependent pathways and a receptor-independent ...
A Brandao-Burch, A Brandao-Burch, A Gartland, A Hoebertz, BA Evans, CG Bellows, DC Genetos, DC Genetos, E Nakamura, G Burnstock, G Burnstock, G Burnstock, G Burnstock, H Fleisch, H Fleisch, H Zimmermann, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, Isabel R. Orriss, J Ham, JL Ramírez-Zacarías, JP Reyes, KA Buckley, KA Buckley, KA Johnson, L Hessle, Luc Malaval, M Ciciarello, M Romanello, Mark O. R. Hajjawi, Michelle L. Key, MP Abbracchio, MW Pfaffl, N Panupinthu, N Panupinthu, N Wang, N Zippel, RM Rumney, S Shimegi, S Syberg, Timothy R. Arnett, V Ralevic, WB Bowler, WE Razzell, WN Addison   +49 more
core   +3 more sources

Purinergic Signaling: A New Regulator of Ovarian Function [PDF]

, 2018
Purinergic signaling is a sophisticated system of elements in which ATP and related molecules function as intercellular messengers. When ATP is released into the extracellular space, it activates specific receptors that belong to the P2 family.
Campos-Contreras, Anaí, Díaz-Muñoz, Mauricio, Juárez-Mercado, Patricia, Velázquez-Miranda, Erandi, Vázquez-Cuevas, Francisco G.   +4 more
core   +1 more source

Purinergic mechanisms in neuroinflammation: An update from molecules to behavior. [PDF]

, 2015
The principle functions of neuroinflammation are to limit tissue damage and promote tissue repair in response to pathogens or injury. While neuroinflammation has utility, pathophysiological inflammatory responses, to some extent, underlie almost all ...
Beamer, Edward, Bekő, Katinka, Gölöncsér, Flóra, Horváth, Gergely, Koványi, Bence, Otrokocsi, Lilla, Sperlágh, Beáta   +6 more
core   +1 more source

Hypoxia induces purinergic receptor signaling to disrupt endothelial barrier function

Frontiers in Physiology, 2022
Blood-brain-barrier permeability is regulated by endothelial junctional proteins and is vital in limiting access to and from the blood to the CNS. When stressed, several cells, including endothelial cells, can release nucleotides like ATP and ADP that ...
Somasundaram Raghavan, Masuma Akter Brishti, Daniel Mohr Collier, M. Dennis Leo   +3 more
doaj   +1 more source