Results 51 to 60 of about 18,523 (160)
Brain and Behavior, Volume 15, Issue 11, November 2025.GI and ND GWAS and blood eQTL data were analyzed using LDSC, HDL, LAVA, GPA, PLACO, FUMA, MAGMA, SMR, HEIDI, and two‐sample MR to assess genetic correlations, pleiotropy, functional annotation, shared gene expression, and causal relationships. ABSTRACT Background This study investigates the shared genetic basis between gastrointestinal (GI) diseases ...
Yan Jiang +3 more
wiley +1 more source
Control of Gut Inflammation by Modulation of Purinergic Signaling
Frontiers in Immunology, 2020 Inflammatory bowel disease (IBD) is a serious inflammatory condition of the gastrointestinal tract. Crohn's disease (CD) and ulcerative colitis (UC) are two of the most common IBD manifestations and are both associated with unfettered inflammation, often
Marta Vuerich +4 more
doaj +1 more source
Adrenergic Control of P2Y6 Receptor‐Dependent Phagocytosis in Rodent and Human Microglia
Glia, Volume 73, Issue 10, Page 2025-2034, October 2025.Main Points Adrenergic signaling through ADRB2 modulates phagocytosis in microglia Crosstalk between ADRB2 and P2Y6 receptors conserved in rodent and human microglia ADRB2 activation inhibits both P2Y6 function and gene expression ABSTRACT Microglia, the resident immune cells of the central nervous system (CNS), are in constant survey of their ...
Thomas Deluc +10 more
wiley +1 more source
P2X and P2Y receptor signaling in red blood cells
Frontiers in Molecular Biosciences, 2015 Purinergic signaling involves the activation of cell surface P1 and P2 receptors by extracellular nucleosides and nucleotides such as adenosine and adenosine triphosphate (ATP), respectively.
Ronald eSluyter +2 more
doaj +1 more source
P2Y1 Receptor as a Catalyst of Brain Neurodegeneration
NeuroSci, 2022 Different brain disorders display distinctive etiologies and pathogenic mechanisms. However, they also share pathogenic events. One event systematically occurring in different brain disorders, both acute and chronic, is the increase of the extracellular ...
Ricardo J. Rodrigues +2 more
doaj +1 more source
Functions of Purinergic Receptors
Receptors P1 and P2 as Targets for Drug Therapy in Humans, 2019 Purinergic receptors, also known as purinoceptors, are a family of plasma membrane molecules found in many mammalian tissues. Purinergic receptors are transmembrane receptors consisting of two main categories.
E. Sarıkaya
semanticscholar +1 more source
British Journal of Pharmacology, Volume 182, Issue 19, Page 4693-4709, October 2025.Background and purpose Traumatic brain injury (TBI) is considered to be a leading cause of mortality and disability worldwide. After TBI, innate immunity is rapidly activated in response to damage‐associated molecular patterns, such as ATP release, recognised by P2X7 receptors.
Inés Valencia +15 more
wiley +1 more source
The bumpy road of purinergic inhibitors to clinical application in immune-mediated diseases
Neural Regeneration ResearchPurinergic signaling plays important roles throughout the body in the regulation of organ functions during and following the disruption of homeostasis. This is also reflected by the widespread expression of two families of purinergic receptors (P1 and P2)
Matthias T Wyss +2 more
doaj +1 more source
Who Is Who in Adenosine Transport
Frontiers in Pharmacology, 2018 Extracellular adenosine concentrations are regulated by a panel of membrane transporters which, in most cases, mediate its uptake into cells. Adenosine transporters belong to two gene families encoding Equilibrative and Concentrative Nucleoside ...
Marçal Pastor-Anglada +3 more
doaj +1 more source
Glia, Volume 73, Issue 8, Page 1642-1659, August 2025.Main Points AQP4ex and OAP‐forming AQP4M23 are expressed in non‐neuronal cells of the olfactory epithelium. AQP4ex‐KO and OAP‐null mice show reduced cell density, including OSNs, and impaired odor responses and behavior, with AQP4ex emerging as key regulator.
Donatella Lobraico +8 more
wiley +1 more source