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Archives of Biochemistry and Biophysics, 2021
The purinergic activation of P2 receptors initiates a powerful and rapid signaling cascade that contributes to the regulation of an array of physiological and pathophysiological processes in many organs, including the kidney. P2 receptors are broadly distributed in both epithelial and vascular renal cells.
Maria Szrejder +2 more
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The purinergic activation of P2 receptors initiates a powerful and rapid signaling cascade that contributes to the regulation of an array of physiological and pathophysiological processes in many organs, including the kidney. P2 receptors are broadly distributed in both epithelial and vascular renal cells.
Maria Szrejder +2 more
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Management of Erectile Function by Penile Purinergic P2 Receptors in the Diabetic Rat
Journal of Urology, 2009We determined the role of purine and pyrimidine nucleotides in erectile function in diabetic rats.A total of 60 adult male rats were divided into 2 groups, including 30 controls and 30 treated with streptozotocin (60 mg/kg) for 8 weeks to induce hyperglycemia.
Serap, Gur +6 more
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Signal Transduction by P2-Purinergic Receptors for Extracellular ATP
American Journal of Respiratory Cell and Molecular Biology, 1991Abstract Extracellular adenosine triphosphate (ATP), at micromolar/nanomolar concentrations, has been shown to induce significant functional changes in a wide variety of normal and transformed cell types. While ATP can be nonspecifically released from the cytosol of damaged cells, it is also co-packaged in certain exocytotic vesicles ...
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Ca2+ mobilization in bovine corneal endothelial cells by P2 purinergic receptors
Current Eye Research, 1998To characterize Ca2+ mobilization by P2 receptors in the bovine corneal endothelial cells (BCEC).Changes in intracellular Ca2+ ([Ca2+]i) were measured by fluorescence imaging of cultured and fresh BCEC cells loaded with the Ca2+-sensitive dye Fura-PE3.
S P, Srinivas +3 more
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P2 purinergic receptors signal to glycogen synthase kinase‐3β in astrocytes
Journal of Neuroscience Research, 2006AbstractGlycogen synthase kinase (GSK)‐3 was identified initially as an enzyme that regulates glycogen synthesis in response to insulin, but more recent studies indicate that it is also involved in numerous cellular processes, including cell survival, cell cycle regulation, proliferation, and differentiation.
Joseph T, Neary, Yuan, Kang
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P2 purinergic receptor antagonists disrupt maternal behavior in lactating rats
Pharmacology Biochemistry and Behavior, 2017The involvement of purinergic signaling in several brain functions has been recognized, but the modulation on maternal behavior by the purinergic system is not established, even though there are functional interactions between the purinergic and oxytocinergic systems.
Luciana C. Teodoro +3 more
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RT-PCR study of purinergic P2 receptors in hematopoietic cell lines
Biochemistry (Moscow), 2006Seven P2X and fifteen P2Y receptors have been identified to date, partly on the basis of amino acid sequence homologies. The expression of all cloned human purinergic P2 receptors was investigated on the messenger RNA level in promonocytic U937 cells, erythroblastic K562 cells, and undifferentiated, dimethyl sulfoxide-differentiated granulocytic, and ...
M K, Bernhard, K, Ulrich
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Purinergic (P2) Receptor-Operated Calcium Entry into Rat Thyroid Cells
Biochemical and Biophysical Research Communications, 1993In the epithelial cell line FRT, derived from rat thyroid, extracellular ATP, at a concentration as low as 1 x 10(-7) M, specifically increases cytosolic Ca++ two fold over the basal level of 255 +/- 45 nM. A maximum increase of 5 fold over basal is seen at 1 x 10(-5) M ATP.
S M, Aloj +3 more
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Glia, 2012
AbstractMicroglia are sensitive to environmental changes and are immediately transformed into several phenotypes. For such dynamic “modal shifts”, purinergic receptors have central roles. When microglia sense ATP/ADP leaked from injured cells by P2Y12 receptors, they are transformed into a moving phenotype, showing process extension and migration ...
Schuichi, Koizumi +3 more
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AbstractMicroglia are sensitive to environmental changes and are immediately transformed into several phenotypes. For such dynamic “modal shifts”, purinergic receptors have central roles. When microglia sense ATP/ADP leaked from injured cells by P2Y12 receptors, they are transformed into a moving phenotype, showing process extension and migration ...
Schuichi, Koizumi +3 more
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Regulation of transcervical permeability by two distinct P2 purinergic receptor mechanisms
American Journal of Physiology-Cell Physiology, 2002Micromolar concentrations of ATP stimulate biphasic change in transepithelial conductance across CaSki cultures, an acute increase (phase I response) followed by a slower decrease ( phase II response). Phase I and phase II responses involve two distinct calcium-dependent pathways, calcium mobilization and calcium influx.
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