Results 131 to 140 of about 8,231 (179)
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Purinergic (P2) Receptors in the Kidney
2003Publisher Summary This chapter focuses on renal P2 receptors and their relationship to the renal effects of adenosine triphosphate (ATP). It also focuses on the nonvascular P2 receptors of renal epithelia. The effects of adenosine on renal function, the distribution of its P1 (A 1–3 subtypes) receptors in kidney tissue, and the potential of this ...
Leipziger, J., Bailey, M.A., Unwin, R.J.
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Effects of P2 purinergic receptor stimulation in brown adipocytes
American Journal of Physiology-Cell Physiology, 1997Sympathetic stimulation of brown adipocytes plays a major role in body energy homeostasis by activating energy-wasting pathways. Sympathetic neuronal input initiates a variety of metabolic, developmental, and membrane responses in brown fat cells. Many of these actions are mediated by adrenergic pathways mobilized by released norepinephrine.
S C, Lee, P A, Pappone
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Involvement of Purinergic P2 Receptors in Experimental Retinal Neovascularization
Current Eye Research, 2008The present study was aimed to investigate the expression of purinergic P2 receptors in oxygen-induced retinal neovascularization.Immunohistochemistry was used to study the expression of purinergic P2Y2 and P2X2 receptors in the neonatal mouse retina during normal vascular development and after oxygen-induced retinopathy (OIR).
Sylvia, Sarman +5 more
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P2 purinergic receptors for diadenosine polyphosphates in the nervous system
General Pharmacology: The Vascular System, 19951. The actions of diadenosine polyphosphates, diadenosine tetraphosphate (Ap4A), diadenosine pentaphosphate (Ap5A) and diadenosine hexaphosphate (Ap6A) in the nervous system have been reviewed. 2. In the peripheral nervous system, diadenosine polyphosphates bind to P2-purinergic receptors such as the P2Y in chromaffin cells and Torpedo synaptosomes ...
J, Pintor, M T, Miras-Portugal
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P2 Purinergic Receptors in Tumor Immunity
Cancer ResearchAbstract P2 purinergic receptors are activated by extracellular ATP and other nucleotides released during cellular stress, hypoxia, or inflammation, serving as key mediators of intercellular communication. In cancer, they rapidly accumulate in the tumor microenvironment following cell death or metabolic stress.
Xin Wang +5 more
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Pharmacological characterization of the renovascular P2 purinergic receptors.
The Journal of Pharmacology and Experimental Therapeutics, 1993Isolated rat kidneys, perfused at a constant flow with a nonrecirculated medium, were used to investigate the effects of P2 purinergic receptor agonists on renal vascular resistance. A potent P2y agonist, 2-methylthio ATP, dilated the kidney in a concentration-dependent manner, a response that was similar to that elicited by acetylcholine.
P C, Churchill, V R, Ellis
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Purinergic P2 receptors as targets for novel analgesics
Pharmacology & Therapeutics, 2006Following hints in the early literature about adenosine 5'-triphosphate (ATP) injections producing pain, an ion-channel nucleotide receptor was cloned in 1995, P2X3 subtype, which was shown to be localized predominantly on small nociceptive sensory nerves. Since then, there has been an increasing number of papers exploring the role of P2X3 homomultimer
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Inhibitory purinergic P2 receptor characterisation in rat distal colon
Neuropharmacology, 2007The aim of this study was to characterise the P2 receptors involved in purinergic relaxant responses in rat distal colon circular muscle. Concentration-response curves for purinergic agonists were constructed on methacholine-precontracted circular muscle strips of rat distal colon in the absence and presence of the nerve blocker TTX and the ecto ...
van Crombruggen, K. +3 more
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P2-Purinergic Receptors: Subtype-Associated Signaling Responses and Structure
Annual Review of Pharmacology and Toxicology, 1995Extracellular adenine nucleotides interact with P2-purinergic receptors to regulate a broad range of physiological processes. These receptors include the P2Y-, P2U-, P2T-, P2X-, and P2Z-purinergic receptor subtypes. This review focuses on the first three of these receptor subtypes, which couple to G proteins and regulate the inositol lipid, cyclic AMP,
T K, Harden, J L, Boyer, R A, Nicholas
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Modulation of Cyclooxygenase‐2 and Brain Reactive Astrogliosis by Purinergic P2 Receptors
Annals of the New York Academy of Sciences, 2001Abstract:Astroglial cells respond to trauma and ischemia with reactive gliosis, a reaction characterized by increased astrocytic proliferation and hypertrophy. Although beneficial to a certain extent, excessive gliosis may be detrimental, contributing to neuronal death in neurodegenerative diseases.
R. Brambilla, M. P. Abbracchio
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