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Purinergic (P2) Receptors in the Kidney
2003Publisher Summary This chapter focuses on renal P2 receptors and their relationship to the renal effects of adenosine triphosphate (ATP). It also focuses on the nonvascular P2 receptors of renal epithelia. The effects of adenosine on renal function, the distribution of its P1 (A 1–3 subtypes) receptors in kidney tissue, and the potential of this ...
Leipziger, J., Bailey, M.A., Unwin, R.J.
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Effects of P2 purinergic receptor stimulation in brown adipocytes
American Journal of Physiology-Cell Physiology, 1997Sympathetic stimulation of brown adipocytes plays a major role in body energy homeostasis by activating energy-wasting pathways. Sympathetic neuronal input initiates a variety of metabolic, developmental, and membrane responses in brown fat cells. Many of these actions are mediated by adrenergic pathways mobilized by released norepinephrine.
S C, Lee, P A, Pappone
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Purinergic (P2) Receptor-Operated Calcium Entry into Rat Thyroid Cells
Biochemical and Biophysical Research Communications, 1993In the epithelial cell line FRT, derived from rat thyroid, extracellular ATP, at a concentration as low as 1 x 10(-7) M, specifically increases cytosolic Ca++ two fold over the basal level of 255 +/- 45 nM. A maximum increase of 5 fold over basal is seen at 1 x 10(-5) M ATP.
S M, Aloj +3 more
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Involvement of Purinergic P2 Receptors in Experimental Retinal Neovascularization
Current Eye Research, 2008The present study was aimed to investigate the expression of purinergic P2 receptors in oxygen-induced retinal neovascularization.Immunohistochemistry was used to study the expression of purinergic P2Y2 and P2X2 receptors in the neonatal mouse retina during normal vascular development and after oxygen-induced retinopathy (OIR).
Sylvia, Sarman +5 more
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Inhibitory purinergic P2 receptor characterisation in rat distal colon
Neuropharmacology, 2007The aim of this study was to characterise the P2 receptors involved in purinergic relaxant responses in rat distal colon circular muscle. Concentration-response curves for purinergic agonists were constructed on methacholine-precontracted circular muscle strips of rat distal colon in the absence and presence of the nerve blocker TTX and the ecto ...
van Crombruggen, K. +3 more
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Pharmacological characterization of the renovascular P2 purinergic receptors.
The Journal of Pharmacology and Experimental Therapeutics, 1993Isolated rat kidneys, perfused at a constant flow with a nonrecirculated medium, were used to investigate the effects of P2 purinergic receptor agonists on renal vascular resistance. A potent P2y agonist, 2-methylthio ATP, dilated the kidney in a concentration-dependent manner, a response that was similar to that elicited by acetylcholine.
P C, Churchill, V R, Ellis
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P2 purinergic receptor antagonists disrupt maternal behavior in lactating rats
Pharmacology Biochemistry and Behavior, 2017The involvement of purinergic signaling in several brain functions has been recognized, but the modulation on maternal behavior by the purinergic system is not established, even though there are functional interactions between the purinergic and oxytocinergic systems.
Luciana C. Teodoro +3 more
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P2 purinergic receptors for diadenosine polyphosphates in the nervous system
General Pharmacology: The Vascular System, 19951. The actions of diadenosine polyphosphates, diadenosine tetraphosphate (Ap4A), diadenosine pentaphosphate (Ap5A) and diadenosine hexaphosphate (Ap6A) in the nervous system have been reviewed. 2. In the peripheral nervous system, diadenosine polyphosphates bind to P2-purinergic receptors such as the P2Y in chromaffin cells and Torpedo synaptosomes ...
J, Pintor, M T, Miras-Portugal
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Purinergic P2 receptors as targets for novel analgesics
Pharmacology & Therapeutics, 2006Following hints in the early literature about adenosine 5'-triphosphate (ATP) injections producing pain, an ion-channel nucleotide receptor was cloned in 1995, P2X3 subtype, which was shown to be localized predominantly on small nociceptive sensory nerves. Since then, there has been an increasing number of papers exploring the role of P2X3 homomultimer
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Archives of Biochemistry and Biophysics, 2021
The purinergic activation of P2 receptors initiates a powerful and rapid signaling cascade that contributes to the regulation of an array of physiological and pathophysiological processes in many organs, including the kidney. P2 receptors are broadly distributed in both epithelial and vascular renal cells.
Maria Szrejder +2 more
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The purinergic activation of P2 receptors initiates a powerful and rapid signaling cascade that contributes to the regulation of an array of physiological and pathophysiological processes in many organs, including the kidney. P2 receptors are broadly distributed in both epithelial and vascular renal cells.
Maria Szrejder +2 more
openaire +2 more sources