Results 191 to 200 of about 28,114 (251)

P2 Purinergic Receptors in Tumor Immunity.

Cancer Research
P2 purinergic receptors are activated by extracellular adenosine triphosphate and other nucleotides released during cellular stress, hypoxia, or inflammation, serving as key mediators of intercellular communication.
Xin Wang, Shuheng Jiang, Mingyue Ma, Shuqi Cai, Dong Song, Bing Han   +5 more
semanticscholar   +3 more sources

P2 purinergic receptors regulate the progression of colorectal cancer

Purinergic Signalling, 2023
More and more studies have revealed that P2 purinergic receptors play a key role in the progression of colorectal cancer (CRC). P2X and P2Y purinergic receptors can be used as promoters and regulators of CRC and play a dual role in the progression of CRC.
Wen-jun Zhang, Li-peng Zhang, Si-jian Lin, Cheng-Yi Wang, Yi-guan Le   +4 more
semanticscholar   +4 more sources

Purinergic P2 receptors as targets for novel analgesics.

Pharmacology & Therapeutics, 2006
Following hints in the early literature about adenosine 5'-triphosphate (ATP) injections producing pain, an ion-channel nucleotide receptor was cloned in 1995, P2X3 subtype, which was shown to be localized predominantly on small nociceptive sensory nerves. Since then, there has been an increasing number of papers exploring the role of P2X3 homomultimer
G. Burnstock
semanticscholar   +3 more sources

The functional role of P2 purinergic receptors in the progression of gastric cancer

Purinergic Signalling
Studies have confirmed that P2 purinergic receptors (P2X receptors and P2Y receptors) expressed in gastric cancer (GC) cells and GC tissues and correlates with their function. Endogenous nucleotides including ATP, ADP, UTP, and UDP, as P2 purinergic receptors activators, participate in P2 purinergic signal transduction pathway.
Fei-long Zou, Ji-Peng Liu, Cheng Zuo, Peng-fei He, Jin Ye, Wen-jun Zhang   +5 more
semanticscholar   +3 more sources

Involvement of Purinergic P2 Receptors in Experimental Retinal Neovascularization

Current Eye Research, 2008
The present study was aimed to investigate the expression of purinergic P2 receptors in oxygen-induced retinal neovascularization.Immunohistochemistry was used to study the expression of purinergic P2Y2 and P2X2 receptors in the neonatal mouse retina during normal vascular development and after oxygen-induced retinopathy (OIR).
Sylvia Sarman, J. Mancini, I. van der Ploeg, J. Croxatto, A. Kvanta, J. Gallo   +5 more
semanticscholar   +3 more sources

Modulation of Cyclooxygenase‐2 and Brain Reactive Astrogliosis by Purinergic P2 Receptors

Annals of the New York Academy of Sciences, 2001
Abstract:Astroglial cells respond to trauma and ischemia with reactive gliosis, a reaction characterized by increased astrocytic proliferation and hypertrophy. Although beneficial to a certain extent, excessive gliosis may be detrimental, contributing to neuronal death in neurodegenerative diseases.
R. Brambilla, M. Abbracchio
semanticscholar   +4 more sources

Management of erectile function by penile purinergic p2 receptors in the diabetic rat.

Journal of Urology, 2009
We determined the role of purine and pyrimidine nucleotides in erectile function in diabetic rats.A total of 60 adult male rats were divided into 2 groups, including 30 controls and 30 treated with streptozotocin (60 mg/kg) for 8 weeks to induce hyperglycemia.
S. Gur, P. Kadowitz, A. Abdel‐Mageed, M. Kendirci, S. Sikka, G. Burnstock, W. Hellstrom   +6 more
semanticscholar   +3 more sources

Purinergic (P2) Receptors in the Kidney

2003
Publisher Summary This chapter focuses on renal P2 receptors and their relationship to the renal effects of adenosine triphosphate (ATP). It also focuses on the nonvascular P2 receptors of renal epithelia. The effects of adenosine on renal function, the distribution of its P1 (A 1–3 subtypes) receptors in kidney tissue, and the potential of this ...
Leipziger, J., Bailey, M.A., Unwin, R.J.
openaire   +3 more sources

Central role of purinergic receptors with inflammation in neuropathic pain-related macrophage-SGC-neuron triad.

Neuropharmacology, 2023
Adenosine triphosphate (ATP) acts on P2 purinergic receptors as an extracellular signaling molecule. P2 purinergic receptors include P2X ionotropic receptors and P2Y metabotropic receptors. Satellite glial cells (SGCs) and macrophages express P2X and P2Y
Runan Yang, Junpei Du, Lin Li, Xiumei Xu, Shangdong Liang   +4 more
semanticscholar   +1 more source

ATP releases ATP or other nucleotides from human peripheral blood leukocytes through purinergic P2 receptors.

Life Science, 2016
AIMS Almost every eukaryotic cell releases ATP under certain conditions. The idea that ATP induces the release of ATP has been scantly investigated. METHODS We explored this possibility by assessing the rate of exogenous ATP breakdown (measured by ...
M. De Ita, M. H. Vargas, V. Carbajal, Blanca Ortiz-Quintero, Cintya López-López, M. Miranda-Morales, C. Barajas-López, L. Montaño   +7 more
semanticscholar   +1 more source