Results 201 to 210 of about 28,114 (251)
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Inhibitory purinergic P2 receptor characterisation in rat distal colon.
Neuropharmacology, 2007The aim of this study was to characterise the P2 receptors involved in purinergic relaxant responses in rat distal colon circular muscle. Concentration-response curves for purinergic agonists were constructed on methacholine-precontracted circular muscle strips of rat distal colon in the absence and presence of the nerve blocker TTX and the ecto ...
K. Crombruggen +3 more
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Effects of P2 purinergic receptor stimulation in brown adipocytes
American Journal of Physiology-Cell Physiology, 1997Sympathetic stimulation of brown adipocytes plays a major role in body energy homeostasis by activating energy-wasting pathways. Sympathetic neuronal input initiates a variety of metabolic, developmental, and membrane responses in brown fat cells. Many of these actions are mediated by adrenergic pathways mobilized by released norepinephrine.
S C, Lee, P A, Pappone
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PharmaNutrition, 2019
Cross-talk between hypertension and diabetes associated with red wine consumption triggering cardioprotective and antihypertensive effects have been well established; nevertheless, the role of isolated total polyphenols from extracts of Vitis vinifera ...
G. H. Bomfim +6 more
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Cross-talk between hypertension and diabetes associated with red wine consumption triggering cardioprotective and antihypertensive effects have been well established; nevertheless, the role of isolated total polyphenols from extracts of Vitis vinifera ...
G. H. Bomfim +6 more
semanticscholar +1 more source
P2 purinergic receptors for diadenosine polyphosphates in the nervous system
General Pharmacology: The Vascular System, 19951. The actions of diadenosine polyphosphates, diadenosine tetraphosphate (Ap4A), diadenosine pentaphosphate (Ap5A) and diadenosine hexaphosphate (Ap6A) in the nervous system have been reviewed. 2. In the peripheral nervous system, diadenosine polyphosphates bind to P2-purinergic receptors such as the P2Y in chromaffin cells and Torpedo synaptosomes ...
J, Pintor, M T, Miras-Portugal
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Extracellular ATP and P2 purinergic signalling in the tumour microenvironment
Nature Reviews. Cancer, 2018 Modulation of the biochemical composition of the tumour microenvironment is a new frontier of cancer therapy. Several immunosuppressive mechanisms operate in the milieu of most tumours, a condition that makes antitumour immunity ineffective.
F. Di Virgilio +4 more
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Pharmacological characterization of the renovascular P2 purinergic receptors.
The Journal of Pharmacology and Experimental Therapeutics, 1993Isolated rat kidneys, perfused at a constant flow with a nonrecirculated medium, were used to investigate the effects of P2 purinergic receptor agonists on renal vascular resistance. A potent P2y agonist, 2-methylthio ATP, dilated the kidney in a concentration-dependent manner, a response that was similar to that elicited by acetylcholine.
P C, Churchill, V R, Ellis
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P2 purinergic receptor expression and function in tumor-related immune cells
Purinergic SignallingP2 purinergic receptor expression is dysregulated in multiple cancer subtypes and is associated with worse outcomes. Studies identify roles for P2 purinergic receptors in tumor cells that drive disease aggressiveness. There is also sufficient evidence that P2 purinergic receptor expression within the tumor microenvironment (TME) is critical for disease
Vahinipriya Manoharan +2 more
semanticscholar +3 more sources
P2-Purinergic Receptors: Subtype-Associated Signaling Responses and Structure
Annual Review of Pharmacology and Toxicology, 1995Extracellular adenine nucleotides interact with P2-purinergic receptors to regulate a broad range of physiological processes. These receptors include the P2Y-, P2U-, P2T-, P2X-, and P2Z-purinergic receptor subtypes. This review focuses on the first three of these receptor subtypes, which couple to G proteins and regulate the inositol lipid, cyclic AMP,
T K, Harden, J L, Boyer, R A, Nicholas
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Signal Transduction by P2-Purinergic Receptors for Extracellular ATP
American Journal of Respiratory Cell and Molecular Biology, 1991Abstract Extracellular adenosine triphosphate (ATP), at micromolar/nanomolar concentrations, has been shown to induce significant functional changes in a wide variety of normal and transformed cell types. While ATP can be nonspecifically released from the cytosol of damaged cells, it is also co-packaged in certain exocytotic vesicles ...
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Ca2+ mobilization in bovine corneal endothelial cells by P2 purinergic receptors
Current Eye Research, 1998To characterize Ca2+ mobilization by P2 receptors in the bovine corneal endothelial cells (BCEC).Changes in intracellular Ca2+ ([Ca2+]i) were measured by fluorescence imaging of cultured and fresh BCEC cells loaded with the Ca2+-sensitive dye Fura-PE3.
S P, Srinivas +3 more
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